Molecular-scale drug delivery systems loaded with oxaliplatin for supramolecular chemotherapy

Yang, Jie; Dai, Dihua; Ma, Lu‐Fang; Yang, Ying‐Wei

doi:10.1016/j.cclet.2020.08.035

Cited by 38 publications

(33 citation statements)

References 62 publications

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“…[26] In view of such a situation, developing convenient, rapid, and selective probes for detecting metal ions is of great significance in environmental remediation. For instance, Wu and co-workers reported a pillar [5]arene-based supramolecular system for detecting mercury ions in water, which was directed by the mechanism of AIE (Figure 1). [19a] Thymine (T)-substituted pillar [5]arene derivative (H1) was designed and synthesized to coordinate with Hg 2 + using the thymine arms to generate TÀ Hg 2 + À T pairings, and accommodate the nitrile-based TPE (G1) in its cavity through host-guest interactions.…”

Section: Detection Of Metal Ionsmentioning

confidence: 99%

“…For instance, Wu and co-workers reported a pillar [5]arene-based supramolecular system for detecting mercury ions in water, which was directed by the mechanism of AIE (Figure 1). [19a] Thymine (T)-substituted pillar [5]arene derivative (H1) was designed and synthesized to coordinate with Hg 2 + using the thymine arms to generate TÀ Hg 2 + À T pairings, and accommodate the nitrile-based TPE (G1) in its cavity through host-guest interactions. Owing to the high affinity between H1 and G1, they assembled to a host-guest complex G1�H1 with very weak fluorescence emission.…”

Section: Detection Of Metal Ionsmentioning

confidence: 99%

“…Recently, Lin, Wei, Liu, and co-workers synthesized a series of organogels with AIE feature on the basis of tripodal pillar [5]arene functionalized supramolecular organic framework (SOF), namely SOF-TPN-G, for the detection of various anions. [20b] Using thioacetylhydrazine-functionalized H5 as the host and 4-aminopyridine-functionalized trimesic amide G3 as the guest, SOF-TPN was prepared through host-guest interactions.…”

Section: Detection Of Anionsmentioning

confidence: 99%

“…Moreover, fluorescent experimental studies demonstrated that the supramolecular system possessed outstanding specificity for Hg 2 + sensing, calculating a LOD of 0.3 μM. Inspired by the significant SAIEE mechanism, some interesting works have been reported by us recently, that is, utilizing the host-guest interactions between functional pillar [5]arenes and TPE derivatives to effectively monitor Fe 3 + and Hg 2 + in water. [28] Under the direction of SAIEE, the fluorescence enhancement will not be limited to the aggregation of single AIEgens, and the assembly of supramolecular polymers is able to promote the process of aggregation for achieving the turn-on property.…”

Section: Detection Of Metal Ionsmentioning

confidence: 99%

“…Over the past half century, supramolecular chemistry has experienced the rapid development and functional materials based on supramolecular assemblies are exploited one after another, for the applications in diverse fields including sensing and detection, [1] organic photoelectronic devices, [2] white light emitter, [3] biomedicine, [4] drug delivery, [5] and separation technology. [6] Supramolecular materials possess appealing superiorities in organizing various components such as supramolecular macrocycles, fluorescent molecules, and functional moieties, endowing the constructed hybrid materials with advanced architectures, desirable morphologies, unique optical effects, and stimuli-responsive properties.…”

Section: Introductionmentioning

confidence: 99%

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Supramolecular Assemblies with Aggregation‐Induced Emission Properties for Sensing and Detection

Dai

Yang

2021

Chemistry A European J

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The fabrication of new supramolecular materials for real‐time detection of analytes including ions, organic pollutants, gases, biomolecules, and drugs is of pivotal importance in industrial manufacture, clinical treatment, and environmental remediation. Incorporating fluorescent molecules with distinct aggregation‐induced emission (AIE) effects into supramolecular assemblies has received much attention over the past two decades, owing to the remarkable performance of the AIE‐active supramolecular materials in sensing and detection. In this minireview, we summarize the recent progress of superior detection systems on the basis of supramolecular assemblies accompanied with AIE features. We envision that this minireview will be helpful and timely for relevant researchers to stimulate new thinking for constructing new AIE‐based supramolecular materials with advanced architectures for effective sensing and detection.

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Section: Detection Of Metal Ionsmentioning

confidence: 99%

Section: Detection Of Metal Ionsmentioning

confidence: 99%

Section: Detection Of Anionsmentioning

confidence: 99%

Section: Detection Of Metal Ionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Supramolecular Assemblies with Aggregation‐Induced Emission Properties for Sensing and Detection

Dai

Yang

2021

Chemistry A European J

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Metal–Organic Framework Nanocomposites in Conquering Hypoxia for Tumor Therapy

Zhou,

Jia,

Wei

et al. 2024

Adv Funct Materials

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Hypoxia, as a distinctive feature of tumors, is closely related to tumor recurrence, metastasis, and treatment resistance. Metal–organic framework (MOF) exhibits an increasing number of advantages in cancer therapy owing to its porous structure, large specific surface area, and tunable function. The MOF nanocomposites constructed by adjusting components can effectively overcome tumor hypoxia and significantly enhance the anti‐tumor effect. In this review, the hypoxic characteristics of tumors and current strategies for constructing MOF nanocomposites that can overcome tumor hypoxia are summarized, including for delivering O2 or endogenously generating O2 to elevate intra‐tumor O2 content; inhibiting HIF‐1 and its induced products to alleviate tumor hypoxia; reducing cellular aerobic respiration to decrease cellular O2 consumption, and exacerbating hypoxia to improve the efficacy of hypoxia‐activated pre‐drugs. At the same time, the applications of MOF nanocomposites applied to overcome tumor hypoxia in different therapeutic methods at the present stage are described, and finally, the challenges and opportunities in further development of MOF nanocomposites are discussed.

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Pillararene‐Based Stimuli‐Responsive Supramolecular Delivery Systems for Cancer Therapy

Li,

Shen,

Yang

et al. 2024

Advanced Materials

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Cancer poses a significant challenge to global public health, seriously threatening human health and life. Although various therapeutic strategies, such as chemotherapy (CT), radiotherapy, phototherapy, and starvation therapy, have been applied to cancer treatment, their limited therapeutic effect, severe side effects, and unsatisfactory drug release behavior need to be carefully considered. Thus, there is an urgent need to develop efficient drug delivery strategies for improving cancer treatment efficacy and realizing on‐demand drug delivery. Notably, pillararenes, as an emerging class of supramolecular macrocycles, possess unique properties of highly tunable structures, superior host–guest chemistry, facile modification, and good biocompatibility, which have been widely used in cancer therapy to achieve controllable drug release and reduce the toxic side effects on normal tissues under various internal/external stimuli conditions. This review summarizes the recent advance of stimuli‐responsive supramolecular delivery systems (SDSs) based on pillararenes for tumor therapy from the perspectives of different assembly methods and hybrid materials, including molecular‐scale SDSs, supramolecular nano self‐assembly delivery systems, and nanohybrid SDSs. Moreover, the prospects and critical challenges of stimuli‐responsive SDSs based on pillararenes for cancer therapy are also discussed.This article is protected by copyright. All rights reserved

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Molecular-scale drug delivery systems loaded with oxaliplatin for supramolecular chemotherapy

Cited by 38 publications

References 62 publications

Supramolecular Assemblies with Aggregation‐Induced Emission Properties for Sensing and Detection

Supramolecular Assemblies with Aggregation‐Induced Emission Properties for Sensing and Detection

Metal–Organic Framework Nanocomposites in Conquering Hypoxia for Tumor Therapy

Pillararene‐Based Stimuli‐Responsive Supramolecular Delivery Systems for Cancer Therapy

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