Molecular response of Drosophila melanogaster tyramine receptor cascade to plant essential oils

Enan, Essam

doi:10.1016/j.ibmb.2004.12.007

Cited by 173 publications

(112 citation statements)

References 51 publications

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“…Guided by the philosophy that evolutionary pressure selects inheritable characteristics confering a reproductive advantage it has been proposed that the TAs confer a selective advantage on certain species of plants due to their ability to deter animal foragers (Smith, 1977;Kawano et al, 2000a;Kawano et al, 2000b;Enan, 2005) in addition to their cultivation by human consumers (Furst, 1972;Furst, 1976;Booth, 1996).…”

Section: Biological Actions Of Trace Aminesmentioning

confidence: 99%

Trace amine-associated receptor 1—Family archetype or iconoclast?

Grandy

2007

Pharmacology & Therapeutics

176

211

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Interest has recently been rekindled in receptors that are activated by low molecular weight, noncatecholic, biogenic amines that are typically found as trace constituents of various vertebrate and invertebrate tissues and fluids. The timing of this resurgent focus on receptors activated by the 'trace amines' (TAs) β-phenylethylamine (PEA), tyramine (TYR), octopamine (OCT), synephrine (SYN), and tryptamine (TRYP) is the direct result of two publications that appeared in 2001 describing the cloning of a novel G protein-coupled receptor (GPCR) referred to by their discoverers as TA1 (Borowsky et al., 2001) and TAR1 (Bunzow et al., 2001). When heterologously expressed in Xenopus laevis oocytes and various eukaryotic cell lines recombinant rodent and human TA receptors dosedependently couple to the stimulation of cAMP production. Structure-activity profiling based on this functional response has revealed that in addition to the TAs, other biologically active compounds containing a 2 carbon aliphatic side chain linking an amino group to at least one benzene ring are potent and efficacious TA receptor agonists with amphetamine, methamphetamine, 3-iodothyronamine, thyronamine, and dopamine among the most notable. Almost 100 years after the search for TA receptors began numerous TA1/TAR1-related sequences, now called Trace AmineAssociated Receptors (TAARs), have been identified in the genome of every species of vertebrate examined to date. Consequently, even though heterologously expressed TAAR1 fits the pharmacological criteria established for a bona fide TA receptor a major challenge for those working in the field is to discern the in vivo pharmacology and physiology of each purported member of this extended family of GPCRs. Only then will it be possible to establish whether TAAR1 is the family archetype or an iconoclast.

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Section: Biological Actions Of Trace Aminesmentioning

confidence: 99%

Trace amine-associated receptor 1—Family archetype or iconoclast?

Grandy

2007

Pharmacology & Therapeutics

176

211

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“…Various studies have indicated that monoterpenoids may have several mechanisms of action. Mechanisms that have been reported include: inhibition of acetylcholinesterase (5,6), binding at the GABA receptor (7)(8)(9)(10)(11), binding at the nicotinic acetylcholine receptor (12), the octopamine receptor (13,14), and the tyramine receptor (15). Previous studies have also described quantitative structure-activity relationships (QSARs) to describe the toxicity of monoterpenoids and their interaction at the GABA receptor (11).…”

mentioning

confidence: 99%

Quantitative Structure-Activity Relationships (QSARs) of Monoterpenoids at an Expressed American Cockroach Octopamine Receptor

Gross

Kimber

Day

et al. 2013

ACS Symposium Series

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Monoterpenoids are found in essential oils from numerous plant families. Octopamine is a biogenic monoamine found within various invertebrates, including insects. Octopamine exerts its physiological effects through the activation of G-protein-coupled receptors (GPCRs). GPCRs are an under-utilized receptor target in the agrochemical industry. Here we report the expression of an octopamine receptor from the brain of the American cockroach (Periplaneta americana) inSaccharomyces cerevisiae, creating a ligand-independent histidine-auxotrophic assay. The majority of monoterpenoids acted as an inverse agonist in this system. Three QSAR models show that electronic properties are most important for monoterpenoid interaction with this octopamine receptor in this yeast assay.

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“…Algunos autores han planteado que los componentes de los aceites esenciales actúan bloqueando los receptores de la octopamina (131) y produciendo alteraciones neurológicas graves con efectos nocivos para los insectos. El eugenol y el timol, por ejemplo, pueden funcionar mediante el bloqueo de estos receptores (147,148). Con el acoplamiento molecular se ha demostrado que el carvacrol, el eugenol y el eucaliptol son capaces de interactuar en el sitio de unión del receptor oamb de la octopamina de Ae.…”

Section: Mecanismo De Acciónunclassified

“…Se ha demostrado que el timol, por ejemplo, interactúa con estos receptores en un sitio de unión aun no identificado (148,149). Algunos sesquiterpenos tricíclicos han resultado ser potentes inhibidores de estos receptores (150).…”

Section: Mecanismo De Acciónunclassified

“…Actualmente, la mayoría de los blancos propuestos para el control de Ae. aegypti, se encuentra en forma cristalizada, registrada en bases de datos como la del Proteín Data Bank (PDB) (145,148,152). En el caso de otros géneros y especies, las secuencias aminoacídicas de estas proteínas se encuentran en bases de datos como las del National Center for Biotechnology Information (NCBI).…”

Section: Mecanismo De Acciónunclassified

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Essential oils and their components as an alternative in the control of mosquito vectors of disease

et al. 2017

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: diseño del trabajo, revisión sistematica de la actividad biológica de los aceites esenciales y revisión del manuscrito Benjamín Nogueda-Torres: diseño del trabajo, revisión sistemática de la actividad de los componentes Alejandro D. Camacho: revisión sistematica de la actividad biológica de los aceites esenciales y revisión del manuscrito Guadalupe Virginia Nevárez-Moorillón: revisión sistematica de la actividad biológica de los aceites esenciales, revisión de los estudios de simulación computacional y modelado molecular de los sesquiterpenos y dianas biológicas, y revisión del manuscrito Luvia E. Sánchez-Torres: revisión sistemática de la actividad de los componentes y escritura del manuscrito Sergio Andrade-Ochoa participó en todas las étapas del estudio. Essential oils and their components as an alternative in the control of mosquito vectors of diseaseMore than half of the human population is exposed to mosquito-borne infections. Climate change and the emergence of strains resistant to traditionally used insecticides have motivated the search of new agents for mosquito population control. Essential oils have been effective repellents and larvicidal agents. The aim of this work was to review research studies conducted in recent years on the larvicidal activity of essential oils and their components against Aedes, Anopheles and Culex mosquitoes, as well as the latest reports about their possible mechanism of action. Más de la mitad de la población humana está expuesta a contraer infecciones transmitidas por mosquitos. La falta de tratamientos y vacunas eficaces para muchas de estas enfermedades hace que su control dependa principalmente de la utilización de agentes insecticidas (1). Los individuos que habitan en las áreas tropicales están más expuestos a contraer enfermedades transmitidas por vectores y este riesgo ha aumentado en otras zonas debido a la globalización (2).Culex, Aedes y Anopheles son vectores de diversas enfermedades, como la filariasis, el dengue, la malaria, y otras. Culex quinquefasciatus está presente en vastas regiones tropicales del mundo, es la principal plaga doméstica en muchas áreas urbanas y está implicada en la transmisión de muchos agentes patógenos, entre ellos, el causante de la filariasis linfática. Esta enfermedad está ampliamente distribuida en las zonas tropicales, con alrededor de 120 millones de personas infectadas en todo el mundo (3).

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Molecular response of Drosophila melanogaster tyramine receptor cascade to plant essential oils

Cited by 173 publications

References 51 publications

Trace amine-associated receptor 1—Family archetype or iconoclast?

Trace amine-associated receptor 1—Family archetype or iconoclast?

Quantitative Structure-Activity Relationships (QSARs) of Monoterpenoids at an Expressed American Cockroach Octopamine Receptor

Essential oils and their components as an alternative in the control of mosquito vectors of disease

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