Molecular resistance mechanisms of Mycoplasma agalactiae to macrolides and lincomycin

Ham, Miranda Prats-van der; Tatay-Dualde, Juan; Fe, Christian de la; Paterna, A.; Sánchez, Antonio; Corrales, J.C.; Contreras, A.; Gómez-Martín, Ángel

doi:10.1016/j.vetmic.2017.10.012

Cited by 16 publications

(12 citation statements)

References 20 publications

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“…2018), antibiotics and antibiotic resistance, which is already in rise in different mycoplasma (Prats-van der Ham et al. 2017; Tatay-Dualde et al. 2017; Yatoo et al.…”

Section: Introductionmentioning

confidence: 99%

Contagious caprine pleuropneumonia – a comprehensive review

Yatoo

Parray

Bashir

et al. 2019

Veterinary Quarterly

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Contagious caprine pleuropneumonia (CCPP) is a serious disease of goats, occasionally sheep and wild ruminants, caused by Mycoplasma capricolum subspecies capripneumoniae (Mccp). The disease is characterized by severe serofibrinous pleuropneumonia, very high morbidity ($100%), and mortality (80-100%). CCPP affects goats in more than 40 countries of the world thereby posing a serious threat to goat farming around the globe. The characteristic clinical signs of CCPP are severe respiratory distress associated with sero-mucoid nasal discharge, coughing, dyspnea, pyrexia, pleurodynia, and general malaise. In later stages, severe lobar fibrinous pleuropneumonia, profuse fluid accumulation in pleural cavity, severe congestion of lungs and adhesion formation is observed. Mycoplasmal antigen interactions with host immune system and its role in CCPP pathogenesis are not clearly understood. CCPP is not a zoonotic disease. Diagnosis has overcome cumbersome and lengthy conventional tests involving culture, isolation, and identification by advanced serological (LAT, cELISA) or gene-based amplification of DNA (PCR, RFLP, and hybridization) and sequencing. The latex agglutination test (LAT) is rapid, simple, and better test for field and real-time diagnosis applicable to whole blood or serum and is more sensitive than the CFT and easier than the cELISA. Moreover, the studies on antibiotic sensitivity and exploration of novel antibiotics (fluoroquinolones, macrolides) can help in better therapeutic management besides preventing menace of antibiotic resistance. Re-visiting conventional prophylactic measures focussing on developing novel strain-based or recombinant vaccines using specific antigens (capsular or cellular) should be the most important strategy for controlling the disease worldwide.

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“…2018), antibiotics and antibiotic resistance, which is already in rise in different mycoplasma (Prats-van der Ham et al. 2017; Tatay-Dualde et al. 2017; Yatoo et al.…”

Section: Introductionmentioning

confidence: 99%

Contagious caprine pleuropneumonia – a comprehensive review

Yatoo

Parray

Bashir

et al. 2019

Veterinary Quarterly

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“…A shift toward higher values (MIC 90 between 2 and 16 µg/mL) was evidenced in Ma, Mcc , and Mp except for Mp with tylosin, see, for instance, Refs. 152, 159, 204. For oxytetracycline, MIC values were higher for Ma than for the M. mycoides cluster 195,198.…”

Section: Means and Relative Effectiveness Of Controlmentioning

confidence: 92%

“…As described in other species,202 CA mycoplasma resistance hinges mostly on point mutations affecting the antimicrobial binding target. Macrolides and lincosamides resistance correlate with mutations in domain V of the 23S rRNA and ribosomal protein L22 in Ma and Mcc isolates 204,206. Increased MIC values with third-generation fluoroquinolones are associated with mutation in the quinolone resistance determining regions of gyrA (Glu87Lys), gyrB (Pro343Leu), and parC (Ser80Thr or Asp84Gly) in Ma and Mcc field isolates 207.…”

Section: Means and Relative Effectiveness Of Controlmentioning

confidence: 99%

“…Finally, for third-generation fluoroquinolones, there is a less marked-shift towards increased MIC values, with MIC remaining low (≤0.5 µg/mL) except in a few Spanish Mcc and Ma strains with values between 1 and 4 µg/mL 159,196Table 3Overview Of MIC Distribution Of CA Mycoplasma Species (Microbroth Or Agar Dilution Methods Depending On The Study) And Main Molecular Resistance Mechanisms When Known Mycoplasma SpeciesFluoroquinolonesPhenicolsTetracyclinesMacrolidesLincosamidesAminosidesENROFFCOXYTYLLINSPTMIC Range MIC 90 Range µg/mLMec.MIC Range MIC 90 Range µg/mLMec.MIC Range MIC 90 Range µg/mLMec.MIC Range MIC 90 Range µg/mLMec.MIC Range MIC 90 Range µg/mLMec.MIC Range MIC 90 Range µg/mLMec. Ma 152,196,198,199,204, 195<0.125–0.8 0.1–0.5 Mutations in QRDR1–8 2–8 ns0.06–8 0.5–8 rrs mutations0.025–16 0.25–8 rrn and L22 coding gene mutations0.125–4 1–4 rrn and L22 coding gene mutations0.4–12.8 2–8 ns Mcc 200,206,2070.025–3.2 0.25–0.4 Mutations in QRDR4–8 8 ns0.25–4 0.5–2 na0.05–12.8 ≤0.03–12.8 rrn and L22 coding gene mutations0.2–12.8 12.8 rrn and L22 coding gene mutations16–128 128 ns Mmc 194,198,...…”

Section: Means and Relative Effectiveness Of Controlmentioning

confidence: 99%

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<p>Contagious Agalactia In Sheep And Goats: Current Perspectives</p>

Jaý¹,

Tardy²

2019

VMRR

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Contagious agalactia (CA) is a disease caused equally by four Mycoplasma species, in single or mixed infections. Clinical signs are multiple, including mastitis, arthritis, keratoconjunctivitis, pneumonia, and septicemia, non-specific, and expressed differently depending whether sheep or goats are affected, on causative mycoplasmas as well as type of husbandry. CA has been reported worldwide and its geographic distribution maps to that of small ruminant breeding areas. However, as current diagnostic tests are expensive and difficult to implement, it is certainly underdiagnosed and prevalence data are only available for a few countries. CA control relies on vaccines, chemotherapy and good herd management practices. It requires long-term commitment but is often unsuccessful, with frequent clinical relapses. The persistence of the etiological agents, despite their overall susceptibility to antimicrobials, comes from their genetic plasticity and capacity to escape the host immune response. The existence of asymptomatic carriers and the numerous sources of infections contribute to rapid spread of the disease and complicate the control and prevention efforts. Here we review all these aspects in order to highlight recent progress made and identify gaps in knowledge or tools needed for better disease management. Discussion also underlines the detrimental effect of contagious agalactia on small ruminant welfare.

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“…Other commonly available and used antibiotics include enrofloxacin, streptomycin, gentamicin, whereas rarely available ones are tylosin, florfenicol, tiamulin and danofloxacin (Sarkar et al, 1992;Bergonier et al, 1997;Kumar et al, 2012;Abraham et al, 2015). Antibiotic resistance is already in rise against many antibiotics by different mycoplasma Prats-van der Ham et al 2017). More therapeutic trials are required for evaluating better curative protocols so as to minimize the risk of antibiotic resistance.…”

Section: Introductionmentioning

confidence: 99%

Mycoplasmosis in Small Ruminants in India: A Review

Yatoo¹,

Kashmir²,

Parray³

et al. 2018

JEBAS

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Mycoplasmosis, the diseases caused by mycoplasma, are one of the challenging and continuous threats to small ruminant farming. They cause heavy morbidity (upto 100%), mortality (10-100%) and huge economic loss. Common diseases caused by mycoplasma organisms are contagious caprine pleuropneumonia (mostly in goats), contagious agalactia (both sheep and goats), atypical pneumonia (usually sheep), besides arthritis, mastitis, seminal vesiculitis, ampullitis, epididymitis, orchitis, urethritis, conjunctivitis and meningitis either alone or as classical syndromes. The common mycoplasma includes Mycoplasma mycoides subspecies mycoides, M. mycoides subsp. capri, M. capricolum subsp. capripneumoniae, M. capricolum subsp. capricolum, M. agalactiae, M. bovis and M. conjunctivae etc. Most of the mycoplasmas produce a conglomerate of clinical signs hampering diagnosis. The other main challenge posed by mycoplasma is the difficulty in isolation due to lack of

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Molecular resistance mechanisms of Mycoplasma agalactiae to macrolides and lincomycin

Cited by 16 publications

References 20 publications

Contagious caprine pleuropneumonia – a comprehensive review

Contagious caprine pleuropneumonia – a comprehensive review

<p>Contagious Agalactia In Sheep And Goats: Current Perspectives</p>

Mycoplasmosis in Small Ruminants in India: A Review

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