Molecular Requirements for Assembly and Intracellular Transport of Class I Major Histocompatibility Complex Molecules

Fourie, Anne M.; Yang, Young Mok

doi:10.1007/978-3-642-72045-1_3

Cited by 6 publications

(4 citation statements)

References 125 publications

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“…It has been shown that Hsp70s and DnaJ homologues are required for ubiquitin-mediated degradation of some proteins (Lee et al 1996;Yaglom et al 1996;Bercovich et al 1997;Fisher et al 1997). Thus, although the MHC-encoded Hsp70s do not seem to be dedicated chaperones for antigen presentation, it is possible that they may affect the repertoire or amount of cytosolic peptides produced by the proteasome, particularly during interferon induction (Fourie and Yang 1998), and in this manner subtly alter the peptide content of surface class I molecules. The dramatic and specific induction of the MHC-encoded Hsp70s in vivo by LPS treatment suggests that they may have a regulatory role in the inflammatory stress response.…”

Section: Discussionmentioning

confidence: 99%

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Characterization and regulation of the major histocompatibility complex–encoded proteins Hsp70-Hom and Hsp70-1/2

Fourie¹,

Peterson²,

Yang³

2001

Cell Stress Chaper

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Vertebrate cells contain at least 12 different genes for Hsp70 proteins, 3 of which are encoded in the major histocompatibility complex (MHC) class III region. In the human MHC, these are named Hsp70-1, -2, and -Hom. To characterize these proteins, we have determined their substrate binding specificity, their cellular and tissue distribution, and the regulation of their expression. We show for the first time (1) peptide binding specificity of Hsp70-Hom; (2) endogenous expression of Hsp70-Hom in human cell lines; (3) cytoplasmic location of Hsp70-Hom protein under basal conditions and concentration in the nucleus after heat shock; (4) unique RNA expression profiles in human tissues for each of the MHC-encoded Hsp70s, significantly different from that for the constitutive Hsc70; (5) a relative increase in levels of Hsp70-Hom protein, compared with other Hsp70s, in response to interferon gamma; and (6) a specific increase on lipopolysaccharide (LPS) treatment of in vivo messenger RNA levels for the MHC-encoded Hsp70s and the DnaJ homologue, hdj2, relative to other chaperones. The unique tissue distributions and specific up-regulation by LPS of the MHC-encoded Hsp70s suggest some specialization of functions for these members of the Hsp70 family, possibly in the inflammatory response.

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Section: Discussionmentioning

confidence: 99%

“…The cytokine interferon gamma plays a critical role in the induction of an immune response (Fourie and Yang 1998). Therefore, to investigate the possible involvement of the MHC-encoded Hsp70s in antigen presentation, we stud- Subcellular locations of Hsp70-1/2 and Hsp70-Hom in HeLa cells.…”

Section: Effects Of Interferon Gamma Treatment Of Hela Cells On Endog...mentioning

confidence: 99%

Characterization and regulation of the major histocompatibility complex–encoded proteins Hsp70-Hom and Hsp70-1/2

Fourie¹,

Peterson²,

Yang³

2001

Cell Stress Chaper

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“…The TcR of CD8+ cells finally recognize the "expressed" antigen [9,10]. These peptides pass into the endoplasmic reticulum (ER), mainly by a transport mechanism (TAP-transporter proteins associated with antigen presentation-ABC proteins), where they find the MHC class I molecules.…”

Section: Antigen Presentation By Class I Mhcmentioning

confidence: 99%

“…This complex migrates to the cell membrane where it is recognized by the TcR of the CD4+ T cell [9,10]. Inside the cell, it is degraded to peptides by proteases.…”

Section: Antigen Presentation By Class II Mhcmentioning

confidence: 99%

Antiviral Immunity

Navarro¹,

Pérez-Ruiz

2011

CIR

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Viruses are obligate intracellular parasites that cause infection by invading cells of the body. Their life cycle comprises a relatively short extracellular period, and a longer intracellular period during which they undergo replication.The immune system has non-specific and specific mechanisms that attack the virus in both phases of its life cycle. Nonspecific immune response is mainly mediated by interferons and natural killer cells (NK). Type I interferons are produced by many cell types and lead to both inhibition of viral replication and cell proliferation; they also enhance the ability of NK to lyse infected cells. NK represent a different lineage of lymphocytes that recognize and lyse virally infected cells. They are mainly effective during an early stage of viral infection, since there is no lag phase of clonal expansion for NK as occurs with T and B lymphocytes. Specific immune antiviral mechanisms are both humoral and cellular. Specific antibodies protect against viral infections and play an important role in antiviral immunity, mainly during the early stage of the infection. The most effective antiviral antibodies are neutralizing antibodies which bind to the viral envelope or capsid proteins, and block the virus from entering into host cell. The main effectors involved in specific antiviral immunity are CD8+ cytotoxic T lymphocytes (CTL). These cells recognize viral antigens presented at the cell surface associated with class I MHC molecules. CTL response is not always beneficial, since the tissue destruction caused by CTL is sometimes greater than the damage done by the virus.

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Evasion of the Immune System by Adenoviruses

Blair

Blair-Zajdel

2004

Current Topics in Microbiology and Immunology

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Molecular Requirements for Assembly and Intracellular Transport of Class I Major Histocompatibility Complex Molecules

Cited by 6 publications

References 125 publications

Characterization and regulation of the major histocompatibility complex–encoded proteins Hsp70-Hom and Hsp70-1/2

Characterization and regulation of the major histocompatibility complex–encoded proteins Hsp70-Hom and Hsp70-1/2

Antiviral Immunity

Evasion of the Immune System by Adenoviruses

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