Molecular regulation of PPARγ/RXRα signaling by the novel cofactor ZFP407
Alyssa Charrier,
Jeremiah Ockunzzi,
Leighanne Main
et al.
Abstract:Cofactors interacting with PPARγ can regulate adipogenesis and adipocyte metabolism by modulating the transcriptional activity and selectivity of PPARγ signaling. ZFP407 was previously demonstrated to regulate PPARγ target genes such as GLUT4, and its overexpression improved glucose homeostasis in mice. Here, using a series of molecular assays, including protein-interaction studies, mutagenesis, and ChIP-seq, ZFP407 was found to interact with the PPARγ/RXRα protein complex in the nucleus of adipocytes. Consist… Show more
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