Molecular Regulation of Lysophosphatidic Acid Receptor 1 Maturation and Desensitization

Lysophosphatidic acid signaling via LPA6: A negative modulator of developmental oligodendrocyte maturation

“…However, much higher ligand concentrations were needed in the in vitro studies. In this context, it has been well‐established that LPA receptors, similar to other G protein‐coupled receptors, can be subject to receptor desensitization (Alcántara‐Hernández et al, 2015; Avendaño‐Vázquez et al, 2005; Solís et al, 2021; Urs et al, 2005; Zhao et al, 2021). Interestingly, next to homologous desensitization by the agonist, there is evidence for agonist‐independent heterologous desensitization (Alcántara‐Hernández et al, 2015; Castillo‐Badillo et al, 2015).…”

“…Intriguingly, a novel compound with selective LPA 6 antagonist activity has recently been reported (Gnocchi et al, 2020). Zhao et al, 2021). Interestingly, next to homologous desensitization by the agonist, there is evidence for agonist-independent heterologous desensitization (Alcántara-Hernández et al, 2015;Castillo-Badillo et al, 2015).…”