Molecular Regulation of Histamine Synthesis

Huang, Hua; Li, Yapeng; Liang, Jinyi; Finkelman, Fred D.

doi:10.3389/fimmu.2018.01392

Cited by 85 publications

(70 citation statements)

References 103 publications

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“…Histamine is of chief clinical significance and major target of anti-allergic drugs (Cataldi et al, 2014). Surprisingly, however, histamine regulation is barely understood, and manifold outnumbered by studies investigating its release over its synthesis (Huang et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

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Yin-Yang of IL-33 in Human Skin Mast Cells: Reduced Degranulation, but Augmented Histamine Synthesis through p38 Activation

Babina

Wang

Franke

et al. 2019

Journal of Investigative Dermatology

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Mast cells (MCs) are the principal effector cells of IgE-mediated allergy. IL-33 is released by resident skin cells as alarmin upon tissue damage or allergen contact. Owing to their pronounced receptor expression, MCs are important targets of IL-33 action, but consequences for skin MCs are ill-defined, especially upon chronic exposure to IL-33. Mimicking the inflammatory milieu of skin disorders, we found that persistent exposure to IL-33 (over a 5-week period) strengthened skin MC numbers through accelerated cell-cycle progression and restriction of apoptosis. Conversely, IL-33 attenuated degranulation and FcεRI expression, potentially as a feedback to chronic "alarmin" exposure. Interestingly, the negative impact on histamine release was counterbalanced by amplified histamine production. Considering the clinical significance of histamine and scarce information on its regulation, we explored the molecular underpinnings. IL-33 induced swift phosphorylation of p38 and JNK (but not of ERK1/2 or AKT), and stimulated histidine decarboxylase expression. Combining pharmacological inhibition and kinase elimination by Accell-facilitated RNA interference in skin MCs revealed a p38-dependent, but JNK-independent mechanism. Collectively, IL-33 exerts multifaceted effects on cutaneous MCs at a post-maturation stage. The IL-33eskin MC axis may contribute to and balance inflammation in chronic skin disorders.

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Section: Discussionmentioning

confidence: 99%

“…The biochemical pathways governing HDC expression and histamine accumulation remain poorly understood despite the amine's key significance to allergic disease (Huang et al, 2018). Its notable upregulation by IL-33 ( Figure 3c) offered an approach to address the mechanism.…”

Section: Il-33 Reinforces Histamine Production In a P38-dependent Butmentioning

confidence: 99%

Yin-Yang of IL-33 in Human Skin Mast Cells: Reduced Degranulation, but Augmented Histamine Synthesis through p38 Activation

Babina

Wang

Franke

et al. 2019

Journal of Investigative Dermatology

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“…[95]. Notably, dietary histidine, a precursor in histamine biosynthesis [96], is found to be an essential amino acid for maintaining histamine levels in the brain [97]. Histidine supplementation is also studied to improve insulin resistance in obese women with metabolic disorders [98].…”

Section: Does Caffeine Augment Histamine-mediated Lipolysis In Adiposmentioning

confidence: 99%

Attenuation of Weight Gain and Prevention of Associated Pathologies by Inhibiting SSAO

2020

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Obesity is a worldwide prevalent metabolic disorder that is associated with diabetes, among many other diseases. Bearing this in mind, prevention and treatment ways need to be improved. Notably, activity of the enzyme semicarbazide-sensitive amine oxidase (SSAO) is found to be elevated in overweight subjects. Moreover, SSAO inhibition has resulted in an increase of histamine activity in adipose tissue and the limitation of body fat. The current review aims to overview the risks of obesity, rationalize the molecular ways of SSAO activity, and outline the strategies of inhibiting upregulated enzyme levels. It describes the differences between SSAO inhibitors and advances the prospective agents. Based on evidence, caffeine is proposed as an effective, safe, and reliable choice to inhibit SSAO activity. Furthermore, the histamine in adipocytes has been associated with SSAO activity. Therefore, it is suggested as one of the key compounds to be studied for obesity management. To conclude, inhibiting SSAO may attenuate weight gain and prevent related diseases.

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“…Histamine has various functions as anaphylaxis mediator, neurotransmitter, and in gastric acid secretion. Histamine is synthesized from histidine by removing the carboxyl group through histidine decarboxylase [ 58 ]. Early on it has been shown that administration of histamine produces a triple response of redness, flare and swelling in addition to itch [ 59 ].…”

Section: Itch Mediators Modulators and Their Receptorsmentioning

confidence: 99%

Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch

Kahremany

Hofmann

Gruzman

et al. 2020

IJMS

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Pruritoceptive (dermal) itch was long considered an accompanying symptom of diseases, a side effect of drug applications, or a temporary sensation induced by invading pruritogens, as produced by the stinging nettle. Due to extensive research in recent years, it was possible to provide detailed insights into the mechanism of itch mediation and modulation. Hence, it became apparent that pruritus is a complex symptom or disease in itself, which requires particular attention to improve patients’ health. Here, we summarize recent findings in pruritoceptive itch, including how this sensation is triggered and modulated by diverse endogenous and exogenous pruritogens and their receptors. A differentiation between mediating pruritogen and modulating pruritogen seems to be of great advantage to understand and decipher the molecular mechanism of itch perception. Only a comprehensive view on itch sensation will provide a solid basis for targeting this long-neglected adverse sensation accompanying numerous diseases and many drug side effects. Finally, we identify critical aspects of itch perception that require future investigation.

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Molecular Regulation of Histamine Synthesis

Cited by 85 publications

References 103 publications

Yin-Yang of IL-33 in Human Skin Mast Cells: Reduced Degranulation, but Augmented Histamine Synthesis through p38 Activation

Yin-Yang of IL-33 in Human Skin Mast Cells: Reduced Degranulation, but Augmented Histamine Synthesis through p38 Activation

Attenuation of Weight Gain and Prevention of Associated Pathologies by Inhibiting SSAO

Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch

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