Molecular regulation, breed differences and genes involved in stress control in farm animals

Durosaro, Samuel O.; Iyasere, Oluwaseun S.; Ilori, Babatunde Moses; Oyeniran, Victor J.; Ozoje, M. O.

doi:10.1016/j.domaniend.2022.106769

Cited by 4 publications

(5 citation statements)

References 80 publications

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“…When the animals received the environmental enrichment there was a greater frequency in the maintenance behaviors, eating (375), gait (281), playing (190), exploring (181), searching (71) and sniffing (42); eating was the more increased With enrichments Frequency behavior during observations with environmental enrichment. On the other hand, also with environmental enrichment some maintenance behaviors decreased, observing the following frequencies: standing (34), wobbling (17), sand baths (10) and trunk swinging with a reduction to (6), whereas without enrichment all these increased their frequency (Figure 10).…”

Section: Resultsmentioning

confidence: 99%

“…Stress is defined as a variety of responses to external or internal stimuli that can modify the homeostasis of individuals [2] [3] [4]. Stress factors are divided into social (isolation, disturbed social order, introduction of animals to a new group and crowding), physiological (hunger, thirst, and dietary changes), physical (injury and fatigue), pathology (diseases and pain) environment (heat and cold) and management (fear) [5] [6]. However, living beings develop physiological systems to be able to buffer adverse environmental conditions and re-establish homeostasis [2].…”

Section: Introductionmentioning

confidence: 99%

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Environmental Enrichment and Its Effect on the Welfare of Two Asian Elephants in Africam Safari Wildlife Conservation Park (Puebla, Mexico)

Pérez Ramírez,

Garcez Mercado,

Rojas Ronquillo

et al. 2023

OJAS

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Animal welfare is important in zoos to maintain the physical well-being and psychological health of individuals. An animal is considered to have welfare if it has good nutrition and also expresses its innate behavior, including sensations and feelings experienced as a result of physical health. The objective of this study was to evaluate the effect of environmental enrichment on the behaviors of two Asian elephants in a wildlife conservation park. The behavior of two Asian elephants, a 46-year-old male and a 59-year-old female, was observed.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Environmental Enrichment and Its Effect on the Welfare of Two Asian Elephants in Africam Safari Wildlife Conservation Park (Puebla, Mexico)

Pérez Ramírez,

Garcez Mercado,

Rojas Ronquillo

et al. 2023

OJAS

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“…Water stress is often associated with high temperatures, and animals that are better able to tolerate heat stress may be more resilient to water scarcity. Genome editing can be used to modify genes involved in heat shock response, such as HSP70, which help protect cells from damage caused by high temperatures (Durosaro et al, 2023). While genome editing for water stress in livestock is a promising approach, there are also some challenges to consider.…”

Section: Mitigating Water Stressmentioning

confidence: 99%

Utilization of Genome Editing for Livestock Resilience in Changing Environment

Ngeno

2023

Black Sea Journal of Agriculture

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Climate change poses a significant threat to livestock production systems, including changes in temperature and rainfall patterns, increased frequency of extreme weather events, and the spread of diseases. The use of genome editing technologies presents a potential solution to mitigate the impacts of climate change on livestock. This paper reviewed the prospects of utilizing genome editing in mitigating the impact of climate change in livestock. Applications of genome editing in development of heat-tolerant, and disease-resistant as well as animals with improved feed and water use efficiency and reduced methane emissions are explored. Additionally, a potential breeding program for gene edited animals is proposed. There are several different genome editing techniques that can be used in livestock breeding, including CRISPR/Cas9, TALENs, and zinc-finger nucleases. These techniques involve introducing specific changes to the animal's genome, such as deleting or replacing genes, or introducing new ones. The technology has enormous potential for improving livestock breeding, as it allows for the creation of animals with desirable traits in a much shorter time frame than traditional breeding methods. Generally, it may take years or even decades to breed an animal with a specific trait using traditional breeding methods, whereas genome editing can achieve the same result in just a few generations. Genome editing can be used to mitigate the impact of climate change on livestock production by reducing the methane emissions by improving the efficiency of feed conversion and modifying the genes responsible for methane production. Technology can be utilized to improve livestock feeds by modifying genes involved in plant growth, development, and nutrient use. This lead to the creation of forages that are high yielding, more nutritious and better adapted to diverse production environments. Genome editing allows development of animals that are more resistant to diseases, which can help reduce the need for antibiotics and other treatments. This is particularly important given the growing problem of antibiotic resistance, which is a major concern in both human and animal health. Genome editing has the potential of developing animals that are thermo-tolerant, as well as animals with improved feed and water use efficiency. The proposed breeding program for gene-edited animals will ensure that the animals produced are healthy, genetically diverse, and meet the desired traits. In terms of ethical concerns, policies for genome editing ought consider the potential for unintended consequences or the creation of animals with characteristics that are viewed as undesirable or unethical Overall, genome editing technology has the potential to revolutionize livestock production and contribute to the global effort to mitigate the impact of climate change.

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“…Due to these specific nutritional characteristics, which can meet the urgent demand for a healthy diet in modern life, the meat rabbit industry in China has been rapidly developed in recent years. However, farm animals, including rabbits, commonly encounter a variety of biotic and abiotic stressors in their lifetimes, such as extreme temperatures, poor nutrition, overproduction, transportation, weaning, infection, and diseases [ 2 ]. These stressors adversely affect the productivity, well-being, and welfare of farm animals, which further leads to significant economic losses in animal husbandry.…”

Section: Introductionmentioning

confidence: 99%

Seasonal Variations in Production Performance, Health Status, and Gut Microbiota of Meat Rabbit Reared in Semi-Confined Conditions

Ye,

Ding,

Pang

et al. 2023

Animals

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In this study, we investigated the variations in production performance, health status, and gut microbiota of meat rabbits raised in the semi-confined barn during summer and winter. Compared to summer, rabbits reared in winter possessed significantly higher slaughter weight and carcass weight. Rabbits fed in the summer were more vulnerable to different stressors, which led to increased protein levels of HSP90, IL-1α, IL-1β, IL-2, and concentrations of MDA, but declined GSH and SOD activities. Additionally, significant differences in gut microbial communities were observed. Compared to the winter, rabbits fed in the summer had significantly lower and higher alpha and beta diversity. Both Firmicutes and Verrucomicrobiota were the dominant phyla, and they accounted for greater proportions in the winter than in the summer. At lower microbial taxa levels, several seasonal differentially enriched microbes were identified, such as Akkermansia muciniphila, the Oscillospiraceae NK4A214 group, the Christensenellaceae R-7 group, Alistipes, and Muribaculaceae. Functional capacities linked to microbial proliferation, nutrient metabolism, and environmental adaptive responses exhibited significantly different abundances between summer and winter. Moreover, strong interactions among different indicators were presented. Based on our findings, we not only proposed several potential strategies to ameliorate the undesirable effects of seasonal changes on the productivity and health of meat rabbits but also underscored the directions for future mechanistic studies of adaptation physiology.

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Molecular regulation, breed differences and genes involved in stress control in farm animals

Cited by 4 publications

References 80 publications

Environmental Enrichment and Its Effect on the Welfare of Two Asian Elephants in Africam Safari Wildlife Conservation Park (Puebla, Mexico)

Environmental Enrichment and Its Effect on the Welfare of Two Asian Elephants in Africam Safari Wildlife Conservation Park (Puebla, Mexico)

Utilization of Genome Editing for Livestock Resilience in Changing Environment

Seasonal Variations in Production Performance, Health Status, and Gut Microbiota of Meat Rabbit Reared in Semi-Confined Conditions

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