Molecular Recognition at Crystal Interfaces

Weissbuch, Isabelle; Addadi, Lia; Lahav, Meir; Leiserowitz, Leslie

doi:10.1126/science.253.5020.637

Cited by 435 publications

(335 citation statements)

References 45 publications

(6 reference statements)

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“…Mann [31] states that this activation energy may also depend on the two-dimensional structure of different crystal faces, indicating that there is a variation in complementarity of various crystal faces and the organic substrate. Weissbuch et al [59] describe the auxiliary molecules which promote or inhibit crystal nucleation depending on their composition.…”

Section: Nucleationmentioning

confidence: 99%

Biological materials: Structure and mechanical properties

Meyers

Chen

Lin

et al. 2008

Progress in Materials Science

2,131

1,129

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Most natural (or biological) materials are complex composites whose mechanical properties are often outstanding, considering the weak constituents from which they are assembled. These complex structures, which have risen from hundreds of million years of evolution, are inspiring Materials Scientists in the design of novel materials.Their defining characteristics, hierarchy, multifunctionality, and self-healing capability, are illustrated. Self-organization is also a fundamental feature of many biological materials and the manner by which the structures are assembled from the molecular level up. The basic building blocks are described, starting with the 20 amino acids and proceeding to polypeptides, polysaccharides, and polypeptides-saccharides. These, on their turn, compose the basic proteins, which are the primary constituents of 'soft tissues' and are also present in most biominerals. There are over 1000 proteins, and we describe only the principal ones, with emphasis on collagen, chitin, keratin, and elastin. The 'hard' phases are primarily strengthened by minerals, which nucleate and grow in a biomediated environment that determines the size, shape and distribution of individual crystals. The most important mineral phases are discussed: hydroxyapatite, silica, and aragonite.Using the classification of Wegst and Ashby, the principal mechanical characteristics and structures of biological ceramics, polymer composites, elastomers, and cellular materials are presented. Selected systems in each class are described with emphasis on the relationship between their structure and mechanical response. A fifth class is added to this: functional biological materials, which have a structure developed for a specific function: adhesion, optical properties, etc.An outgrowth of this effort is the search for bioinspired materials and structures. Traditional approaches focus on design methodologies of biological materials using conventional synthetic 0079-6425/$ -see front matter Ó

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Section: Nucleationmentioning

confidence: 99%

Biological materials: Structure and mechanical properties

Meyers

Chen

Lin

et al. 2008

Progress in Materials Science

2,131

1,129

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“…The complexity of multiple conformations while dealing with pharmaceutically relevant molecules makes extension of such theories to pharmaceuticals rather difficult and may be the cause of limited progress in this area. While the advancement of supramolecular chemistry in disciplines such as ceramics, photography, and semiconductors has therefore been significant, the concept is still at its inception in pharmaceuticals and has only occasionally been reported [8,[10][11][12].This body of work is intended to serve as a proof of concept for the application of supramolecular chemistry in drug development. In particular, this work is designed to evaluate crystal doping by recrystallization from supercritical media.…”

Section: Introductionmentioning

confidence: 99%

Crystal doping aided by rapid expansion of supercritical solutions

2002

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The purpose of this study was to test the utility of rapid expansion of supercritical solution (RESS) based cocrystallizations in inducing polymorph conversion and crystal disruption of chlorpropamide (CPD). CPD crystals were recrystallized by the RESS process utilizing supercritical carbon dioxide as the solvent. The supercritical region investigated for solute extraction ranged from 45 to 100°C and 2000 to 8000 psi. While pure solute recrystallization formed stage I of these studies, stage II involved recrystallization of CPD in the presence of urea (model impurity). The composition, morphology, and crystallinity of the particles thus produced were characterized utilizing techniques such as microscopy, thermal analysis, x-ray powder diffractometry, and high-performance liquid chromatography. Also, comparative evaluation between RESS and evaporative crystallization from liquid solvents was performed. RESS recrystallizations of commercially available CPD (form A) resulted in polymorph conversion to metastable forms C and V, depending on the temperature and pressure of the recrystallizing solvent. Cocrystallization studies revealed the formation of eutectic mixtures and solid solutions of CPD + urea. Formation of the solid solutions resulted in the crystal disruption of CPD and subsequent amorphous conversion at urea levels higher than 40% wt/wt. Consistent with these results were the reductions in melting point (up to 9°C) and in the ∆H f values of CPD (up to 50%). Scanning electron microscopy revealed a particle size reduction of up to an order of magnitude upon RESS processing. Unlike RESS, recrystallizations from liquid organic solvents lacked the ability to affect polymorphic conversions. Also, the incorporation of urea into the lattice of CPD was found to be inadequate. In providing the ability to control both the particle and crystal morphologies of active pharmaceutical ingredients, RESS proved potentially advantageous to crystal engineering. Rapid crystallization kinetics were found vital in making RESS-based doping superior to conventional solvent-based cocrystallizations.

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“…79 Peptide selectivity is likely due to the recognition of a combination of chemical (hydrogen bonding, polarity, and charge effects) and structural (size and morphology) features. 80,81 Whaley et al 29 described a peptide that was specific not only to gallium arsenide over silicon, but bound the (100) crystal face over the (111)B. The specificity of another gold binding peptide, GBP1, was examine using a quartz-crystal microbalance and was found to preferentially absorb to gold over platinum and silica, and suggested that polar moieties and the physical conformation of the peptide itself may play a role in the binding preference to gold over platinum or silica.…”

Section: Selectivity Of Gold-binding Peptidesmentioning

confidence: 99%

Functional and Selective Bacterial Interfaces Using Cross-Scaffold Gold Binding Peptides

Adams

Hurley

Jahnke

et al. 2015

JOM

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We investigated the functional and selective activity of three phage-derived gold-binding peptides on the Escherichia coli (E. coli) bacterial cell surface display scaffold (eCPX) for the first time. Gold-binding peptides, p3-Au12 (LKAHLPPSRLPS), p8#9 (VSGSSPDS), and Midas-2 (TGTSVLIATPYV), were compared side-by-side through experiment and simulation. All exhibited strong binding to an evaporated gold film, with approximately a 4-log difference in binding between each peptide and the control sample. The increased affinity for gold was also confirmed by direct visualization of samples using Scanning Electron Microscopy (SEM). Peptide dynamics in solution were performed to analyze innate structure, and all three were found to have a high degree of flexibility. Preferential binding to gold over silicon for all three peptides was demonstrated, with up to four orders of magnitude selectivity exhibited by p3-Au12. The selectivity was also clearly evident through SEM analysis of the boundary between the gold film and silicon substrate. Functional activity of bound E. coli cells was further demonstrated by stimulating filamentation and all three peptides were characterized as prolific relative to control samples. This work shows great promise towards functional and active bacterial-hybrid gold surfaces and the potential to enable the next generation living material interfaces.

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Molecular Recognition at Crystal Interfaces

Cited by 435 publications

References 45 publications

Biological materials: Structure and mechanical properties

Biological materials: Structure and mechanical properties

Crystal doping aided by rapid expansion of supercritical solutions

Functional and Selective Bacterial Interfaces Using Cross-Scaffold Gold Binding Peptides

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