Molecular prognostic indicators in HPV-positive oropharyngeal cancer: an updated review

Morand, G; Diaconescu, A.; Ibrahim, Iman; Lamarche, Genevieve; Ruas, Juliana S.; Dalfen, Jacqueline; Hier, Michael P.; Alaoui‐Jamali, Moulay A.; Maschietto, Mariana; Silva, Sabrina Daniela da

doi:10.1007/s10585-022-10148-9

Cited by 9 publications

(11 citation statements)

References 56 publications

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“…Molecular biomarkers that reflect the unique biology of HPV + OPSCC such as tumour hypoxia, mutation status, or immune activation may refine patient prognosis and selection for de-escalation clinical trials. 63 In the current study, we demonstrate that the pre-treatment TME has dramatic effects in determining the prognosis of HPV + OPSCC patients. Further, we describe a clinically translatable, extensively validated UWO3 immune classification tool that may allow biomarker-driven individualized treatment in HPV + OPSCC ( Fig.…”

Section: Discussionsupporting

confidence: 49%

Immune-based classification of HPV-associated oropharyngeal cancer with implications for biomarker-driven treatment de-intensification

Zeng¹,

Cecchini²,

Barrett³

et al. 2022

eBioMedicine

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Section: Discussionsupporting

confidence: 49%

Immune-based classification of HPV-associated oropharyngeal cancer with implications for biomarker-driven treatment de-intensification

Zeng¹,

Cecchini²,

Barrett³

et al. 2022

eBioMedicine

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“…Oropharyngeal squamous cell carcinoma (OPSCC) arises most commonly in the palatine tonsils or the base of the tongue. As with other squamous cell carcinomas f the head and neck, it is classically caused by exposure to extrinsic carcinogens such as smoking and alcohol [ 1 ]. Since the late 1990s, there has been a rise in oropharyngeal cancer related to human papillomavirus (HPV) infection, especially in high-income countries [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Patients are younger, healthier, and with a higher socioeconomic status [ 2 , 7 ]. They also have a better prognosis than their HPV-negative counterparts [ 1 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Vaccines for HPV-Associated Oropharyngeal and Cervical Cancer: The Next De-Intensification Strategy?

Morand

Cardona

Cruz

et al. 2022

IJMS

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The rise in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) has prompted a quest for further understanding of the role of high-risk HPV in tumor initiation and progression. Patients with HPV-positive OPSCC (HPV+ OPSCC) have better prognoses than their HPV-negative counterparts; however, current therapeutic strategies for HPV+ OPSCC are overly aggressive and leave patients with life-long sequalae and poor quality of life. This highlights a need for customized treatment. Several clinical trials of treatment de-intensification to reduce acute and late toxicity without compromising efficacy have been conducted. This article reviews the differences and similarities in the pathogenesis and progression of HPV-related OPSCC compared to cervical cancer, with emphasis on the role of prophylactic and therapeutic vaccines as a potential de-intensification treatment strategy. Overall, the future development of novel and effective therapeutic agents for HPV-associated head and neck tumors promises to meet the challenges posed by this growing epidemic.

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“…Due to the high tropism of the virus in the epithelium and similarities between genital and oropharyngeal epithelia, HPV is responsible not only for cervical tumors but also for 25% of head and neck squamous cell carcinoma (HNSCC) cases, particularly in the oropharyngeal region, with an incidence of HPV in up to 70% of cases [ 4 ]. The etiological role of tobacco and alcohol is well established, and micronutrient deficiencies and poor oral hygiene are also associated with a high risk of developing such neoplasms [ 5 ]. However, in recent decades an increasing prevalence of HPV in HNSCC has been reported, with a positivity rate up to 80% for this type of tumor [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…High-risk HPV genotypes, including types 16, 18, 26, 31, 33, 35, 39, 45, 51–53, 56, 58, 59, 66, 68, 70, 73, and 82, are related to the development of tumors in the oral cavity of the oropharynx, and in genitals and the anal area [ 7 ]. Following high-risk HPV infection, the expression of E6 and E7 proteins inhibits tumor suppressors RB and p53 and induces the malignant transformation of cells [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Human Papillomavirus in the Oropharynx of Healthy Individuals in an Italian Population

Palmieri

Lauritano

Pellati

et al. 2022

JCM

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Oral cavity and oropharynx cancer associated with human papil loma virus infection, particularly in young people who are continuously exposed to this virus, is a serious public health problem worldwide, especially for high-risk strains that are most associated with premalignant lesions and tumors. These neoplasms remain asymptomatic for a long time and, when they occur, they are already at an advanced stage. If diagnosed and treated early, oral cancer induced by human papilloma virus allows for high survival, as it often has a more favorable prognosis than oral cancers not directly related to viral infection. In this study, the presence of different high-risk and low-risk HPV strains was investigated to assess the epidemiological status in a population of healthy individuals. Two types of samples, one from the tonsils and one from the base of the tongue, were collected from 2015 healthy individuals of different sex and age. A total of 1885 DNA samples belonging to 1285 patients were tested for the presence of 11 high-risk HPV types plus 4 low-risk HPV types using real-time PCR. Of the patients’ DNA samples screened for 15 HPV types, only four samples were positive, all of which were taken from male smokers. These results indicate that newly acquired oral oncogenic HPV infections in the healthy population are rare and, in many cases, controversial. Therefore, more studies are needed to ensure fewer variations in outcomes and a greater clarification of HPV infection and its prevalence in the oropharynx of the healthy population, and to guide efforts to prevent the development of this infection which, if undiagnosed, can lead to the onset of malignant tumors in the oral cavity.

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Molecular prognostic indicators in HPV-positive oropharyngeal cancer: an updated review

Cited by 9 publications

References 56 publications

Immune-based classification of HPV-associated oropharyngeal cancer with implications for biomarker-driven treatment de-intensification

Immune-based classification of HPV-associated oropharyngeal cancer with implications for biomarker-driven treatment de-intensification

Therapeutic Vaccines for HPV-Associated Oropharyngeal and Cervical Cancer: The Next De-Intensification Strategy?

Prevalence of Human Papillomavirus in the Oropharynx of Healthy Individuals in an Italian Population

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