Molecular Profiling of Papillary Thyroid Carcinoma in Korea with a High Prevalence ofBRAF^V600EMutation

Abstract

Genetic alterations in PTC vary among its different histologic variants and seem to be different in each ethnic group.

Identification of distinct cytomorphologic features in the diagnosis of NIFTP at the time of preoperative FNA: Implications for patient management

“…Interestingly, BRAF V600E mutations have rarely been reported in NIFTP cases . In contrast, many other studies, including the original article by Nikiforov et al outlining the nomenclature change to NIFTP, have not shown BRAF V600E mutations in their reported NIFTP cases .…”

Interobserver and intraobserver variation in the morphological evaluation of noninvasive follicular thyroid neoplasm with papillary‐like nuclear features in Asian practice

“…NIFTP is a morphological phenotype consistent with RAS ‐like tumor, and cases with BRAF and/or TERT promoter mutation must be excluded, as per the current concept . BRAF V600E mutation was reported in “NIFTP” that fulfilled the morphological criteria by several research groups . These results show that the current nuclear score systems (either three‐point or eight‐point) are not able to differentiate noninvasive follicular patterned thyroid tumors with BRAF V600E mutation and/or lymph node metastasis from NIFTP.…”

“…However, this study was based on a single high power still image per case, which probably could not reproduce the whole complexity of lesion encountered in practical settings. In addition, several recent institutional reports from the USA and Korea described NIFTP cases with BRAF V600E and TERT promoter mutations characteristic for conventional PTC . These controversial findings prompted ramifications of NIFTP diagnostic criteria released in 2018 .…”

Noninvasive follicular neoplasm with papillary like nuclear features: A comprehensive analysis with a diagnostic algorithm

“…In spite of Asian continent being a major contributor to worldwide prevalence of thyroid cancer (according to GLOBOCON database; estimated 48% new cases in 2012), the prevalence of NIFTP in Asians has not been reported extensively as compared with the western world . There are limited studies from Asia and even fewer form India and those present have reported a significantly lower prevalence (0%‐5%) as compared to western data (15%‐25%) …”

“…The extent of all the changes related to the NIFTP reclassification apparently depends on the incidence of NIFTP in a certain population. Approximately, 30 studies have been conducted in America, Europe and Asia reporting variable incidence . Bychkov et al, in a meta‐analysis, documented an average worldwide prevalence rate of 9.1%, with a lower rate in Asian studies (1.6%) as compared with non‐Asian countries (13.3%) .…”