Molecular profiling of clinical remission in psoriatic arthritis reveals dysregulation of FOS and CCDC50 genes: a gene expression study

Angioni, Maria Maddalena; Floris, Alberto; Cangemi, Ignazio; Congia, Mattia; Chessa, Elisabetta; Naitza, Micaela Rita; Piga, Matteo; Cauli, Alberto

doi:10.3389/fimmu.2023.1274539

Cited by 2 publications

References 41 publications

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Treatment of psoriasis with different classes of biologics reduces the likelihood of peripheral and axial psoriatic arthritis development

Floris,

Mugheddu,

Sichi

et al. 2024

Rheumatology

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OBJECTIVE To assess the potential role of biological treatment for psoriasis (PsO) in reducing the likelihood of psoriatic arthritis (PsA), through a detailed analysis that considered the different historical phases in the PsA management, the different biologics classes, and the different patterns of articular involvement. METHODS A monocentric cohort of 1023 PsO patients underwent a rheumatologic assessment in which clinical and therapeutic data were recorded. Chi-squared test and multivariate logistic regression analysis (adjusted for the main PsA risk factors) were performed to compare the likelihood of PsA development in different treatment groups. RESULTS The PsA prevalence in PsO patients treated at least once with biologics was significantly lower than in patients never treated with biologics (8.9% vs 26.1%, p< 0.001). In multivariate analysis, a significantly (p< 0.01) lower likelihood of PsA development in biologic-treated patients was confirmed in the whole cohort (adjOR 0.228), as well as in the subgroups of patients with PsO onset after 2005 (adjOR 0.264) and after 2014 (adjOR 0.179). Separately analysing the different biologics classes, both the TNF (adjOR 0.206), IL-17 (adjOR 0.051) and IL-23 or 12/23 (adjOR 0.167) inhibitors were significantly (p< 0.01) associated with a lower likelihood of PsA development. Finally, patients treated with biologics had a significantly (p< 0.04) lower prevalence of both pure peripheral PsA (adjOR 0.182) and peripheral PsA with axial involvement (adjOR 0.115). CONCLUSIONS This study provides meaningful and concordant evidence supporting the significant role of different classes of biologics in reducing the likelihood of peripheral and axial PsA development.

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Treatment of psoriasis with different classes of biologics reduces the likelihood of peripheral and axial psoriatic arthritis development

Floris,

Mugheddu,

Sichi

et al. 2024

Rheumatology

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Exploration of common genomic signatures of Systemic juvenile rheumatoid arthritis and Kawasaki disease

Zhong,

Wu,

et al. 2024

Preprint

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To investigate the common genetic patterns and possible molecular processes involved in systemic juvenile idiopathic arthritis (SJIA) and Kawasaki disease (KD). The methodology involved the retrieval and analysis of microarray data for SJIA and KD from the Gene Expression Omnibus (GEO) database. The researchers employed the ExpressAnalystR software to ascertain the differentially expressed genes (DEGs) that were shared, and subsequently identified genes associated with extracellular proteins within this set. Transcription factors (TFs) and their corresponding target genes in single-domain encoding genes (SDEGs) were acquired by a comparative analysis of databases such as HumanTFDB and hTFtarget. Subsequently, the gene sets that had been previously identified underwent functional enrichment analysis using the metascape program. Ultimately, the analysis of immune infiltration was conducted using CIBERSORT. The study revealed a total of 204 up-regulated and 35 down-regulated SDEGs. Through the construction of a network targeting transcription factors (TFs), 4 specific TFs (EGR1, BCL6, FOS, and NFE2) were identified and further screened. Functional enrichment analysis and immune infiltration findings indicate that both the adaptive and innate immune systems play significant roles in the development of systemic juvenile idiopathic arthritis (SJIA) and Kawasaki disease (KD). Signaling pathways, such as NF-kB, are crucial in the pathogenesis of these conditions, along with biological processes like tumor necrosis factor (TNF) functions and neutrophil degranulation. The findings of our investigation provided comprehensive evidence regarding the intricate and adaptable nature of the immune system abnormalities associated with SJIA and KD. The same pathogenic mechanism may involve the actions of TNF, neutrophil degranulation, and the NF-kB pathway. Furthermore, it is imperative to carry out a more comprehensive investigation of the regulatory functions of EGR1, BCL6, FOS, and NFE2 within this network.

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Molecular profiling of clinical remission in psoriatic arthritis reveals dysregulation of FOS and CCDC50 genes: a gene expression study

Cited by 2 publications

References 41 publications

Treatment of psoriasis with different classes of biologics reduces the likelihood of peripheral and axial psoriatic arthritis development

Treatment of psoriasis with different classes of biologics reduces the likelihood of peripheral and axial psoriatic arthritis development

Exploration of common genomic signatures of Systemic juvenile rheumatoid arthritis and Kawasaki disease

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