Molecular precursor method for thin calcium phosphate coating on titanium

Takahashi, Kenichi; Hayakawa, Tohru; Yoshinari, Masao; Mochizuki, Chihiro; Sato, Mitsunobu; Nemoto, Kimiya

doi:10.1016/j.tsf.2004.12.052

Cited by 36 publications

(37 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, excellent adhesion of the coated film to the titanium after PBS immersion was confirmed by measurement of tensile bond strength and a scratch test. Although there is a difference between titanium and TCP, it was predicted from previous titanium data that the adherence of coated apatite to TCP in buffered solution would be sufficient 10) .…”

Section: Discussionmentioning

confidence: 99%

“…Takahashi et al evaluated the characteristics of an apatite coating layer produced by the molecular precursor method 10) . When carbonate-containing HA was deposited onto titanium, the coating thickness and Ca/P ratio were about 0.44 ± 0.01 ìm and 1.56 ± 0.04, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, physical vapor deposition methods, such as sputtering and plasma-spraying, are the main methods used to apply HA coatings; however, with these methods it is difficult to achieve a uniform thin coating on complex threedimensional porous structures. Recently, a molecular precursor method, with which it is easy to produce a uniform thin HA coating on porous structures, was developed [10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Thin Hydroxyapatite Coating on Porous Beta-Tricalcium Phosphate (β-TCP) Enhances Osteoblast Function Activity

Monden

Hirota

Hayakawa

et al. 2012

J. Hard Tissue Biology.

Self Cite

View full text Add to dashboard Cite

Abstract:We evaluated the properties of porous beta-tricalcium phosphate (β-TCP) coated with a thin layer of hydroxyapatite (HA) using a molecular precursor method. Samples of HA-coated beta-TCP (HATCP) and non-coated β-TCP (TCP) were used for osteoblast culture. The proliferation and function of osteoblasts cultured in the samples were evaluated. Osteoblast proliferation and mineralization activity and secretion of osteoclast activating factors in the samples were observed. The thin HA coating on porous β-TCP was not affected to the three dimensional structures. The calcium concentration with osteoblast was significantly higher in the HATCP group, suggesting the thin HA coating enhanced mineralization activity of osteoblast. Osteoblast proliferation activity was similar in the TCP and HATCP groups. Then, osteoclast activating factors seen in HATCP were more than those in TCP. These results suggest that a thin HA coating on porous β-TCP enhanced osteoblast function activity without reducing proliferation activity.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Thin Hydroxyapatite Coating on Porous Beta-Tricalcium Phosphate (β-TCP) Enhances Osteoblast Function Activity

Monden

Hirota

Hayakawa

et al. 2012

J. Hard Tissue Biology.

Self Cite

View full text Add to dashboard Cite

show abstract

“…15) The method to prepare the molecular precursor solution was described in detail in a previous study 11) . Briefly, the solution was made by mixing Ca-EDTA/amine ethanol solution and metaphosphate salt, and the Ca/P ratio was adjusted to 1.67 (Fig.…”

Section: Ha-tw Scaffoldmentioning

confidence: 99%

“…Thin RF magnetron sputter coating could not penetrate completely throughout the mesh due to the complex three-dimensional (3-D) structure 10) . Recently, Hayakawa and colleagues developed a thin HA coating technique named the "molecular precursor method" 11) , and a sufficient apatite coating was achieved inside TW. The hydroxyapatite-coated titanium fiber web (HA-TW) using the coating technique showed apatite crystal formation in a human osteoblast culture 12) .…”

Section: Introductionmentioning

confidence: 99%

Guided Bone Regeneration using Hydroxyapatite-Coated Titanium Fiber Web in Rabbit Mandible: Use of Molecular Precursor Method

Ueno

Sato

Hayakawa

2013

J. Hard Tissue Biology.

Self Cite

View full text Add to dashboard Cite

As a non-degradable material showing excellent biological compatibility and mechanical properties, the titanium fiber web (TW) scaffold has been applied in bone regeneration. It is generally accepted that hydroxyapatite (HA) coating accelerates osteoblast maturation and functional activity on the titanium surface. Recently, a thin HA coating using the molecular precursor method was developed, and sufficient apatite coating was achieved inside TW. The aim of the present study was to evaluate the bone-forming capacity using HAcoated TW (HA-TW) in external augmentation. Sintered titanium fiber mesh was processed into a threedimensional scaffold structure with a fiber diameter of approximately 20 μm. The external and internal diameters of TW were 8.0 and 3.7 mm, respectively. The molecular precursor solution was made by mixing Ca-EDTA/ amine ethanol solution and metaphosphate salt, and the Ca/P ratio was adjusted to 1.67. After immersing TW in the solution, it was heated at 600 for 2 hours. Six rabbits were assigned randomly to receive either HA-TW scaffold or TW on each side of the posterior mandible. The 3-mm-long toroidal titanium scaffolds were fitted into the osseous implant. Both TW-and HA-TW-fixed implants were then placed bilaterally with a transverse orientation. The animals were sacrificed at 12 weeks post-surgery, and new bone formation into the porous structure of TW and HA-TW was observed in non-decalcified sections. The newly formed bone rate in the HA-TW was significantly greater than that in the non-coated group (8.33±1.21 vs. 3.43±0.45 %, respectively). Furthermore, the rate of vertical bone regeneration was also significantly different between HA-TW and TW (63±15 vs. 33±8 %). Since the thin HA coating improved bone formation in externally placed TW, HA-TW is potentially useful for external bone augmentation.

show abstract

The Science of Molecular Precursor Method

Nagai

Sato

2018

Advanced Coating Materials

View full text Add to dashboard Cite

Molecular precursor method for thin calcium phosphate coating on titanium

Cited by 36 publications

References 28 publications

Thin Hydroxyapatite Coating on Porous Beta-Tricalcium Phosphate (β-TCP) Enhances Osteoblast Function Activity

Thin Hydroxyapatite Coating on Porous Beta-Tricalcium Phosphate (β-TCP) Enhances Osteoblast Function Activity

Guided Bone Regeneration using Hydroxyapatite-Coated Titanium Fiber Web in Rabbit Mandible: Use of Molecular Precursor Method

The Science of Molecular Precursor Method

Contact Info

Product

Resources

About