Molecular phylogeny of the speciose vole genus Microtus (Arvicolinae, Rodentia) inferred from mitochondrial DNA sequences

Jaarola, Maarit; Martínková, Natália; Gündüz, İslam; Brunhoff, Cecilia; Zima, Jan; Nadachowski, Adam; Amori, Giovanni; Bulatova, N. Sh.; Chondropoulos, B.P.; Fraguedakis-Tsolis, Stella; González‐Esteban, Jorge; López-Fuster, María José; Kandaurov, Andrei; Kefelioğlu, Haluk; Mathias, Maria da Luz; Villate, Idoia; Searle, Jeremy B.

doi:10.1016/j.ympev.2004.07.015

Cited by 289 publications

(356 citation statements)

References 56 publications

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“…Because a regional partition of cytb haplotypes according to introgression status was observed in M. lusitanicus (Bastos-Silveira et al, 2012;Barbosa et al, 2013), we reconstructed the phylogenetic tree of M. lusitanicus and M. duodecimcostatus using all the cytb sequences available in GenBank and assigned each specimen to its place of origin to investigate any connection between the geographical distribution of p53 and cytb haplotypes. A total of 129 cytb haplotypes were retrieved from all the published sequences of each species, 77 haplotypes from 79 individuals of M. lusitanicus and 52 from 55 specimens of M. duodecimcostatus (accession numbers in Supplementary Table S2; Jaarola et al, 2004;Tougard et al, 2008;Bastos-Silveira et al, 2012;Barbosa et al, 2013). For the construction of the cytb phylogenetic tree the TIM3 substitution model was chosen with a proportion of invariable sites and a gamma-distributed rate variation across sites (TIM3+I+G).…”

Section: Dna Extraction P53 Amplification and Sequencingmentioning

confidence: 99%

“…Here we performed a population-genetic analysis involving 96 individuals (52 M. lusitanicus and 44 M. duodecimcostatus) sampled in the Iberian Peninsula, and the p53 DNA sequence encoding part of the DNAbinding region of P53, from the 3′ end of exon 5 to the 5′ extreme of exon 7, which includes residue 174. We used specimens captured both in allopatric and sympatric areas where introgressed animals have been observed (Jaarola et al, 2004;Tougard et al, 2008;Bastos-Silveira et al, 2012;Barbosa et al, 2013;Rodriguez-Prieto et al, 2014), to ultimately evaluate whether genes involved in the differentiation of species separated recently carry signature changes reflecting speciation more accurately than neutral genes (Ting et al, 2000). Variability of the obtained p53-coding sequences of M. lusitanicus and M. duodecimcostatus was further compared with the published sequences from other Microtus species, rodents and mammals.…”

Section: Introductionmentioning

confidence: 99%

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p53 gene discriminates two ecologically divergent sister species of pine voles

et al. 2015

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Genes with relevant roles in the differentiation of closely-related species are likely to have diverged simultaneously with the species and more accurately reproduce the species tree. The Lusitanian (Microtus lusitanicus) and Mediterranean (M. duodecimcostatus) pine voles are two recently separated sister species with fossorial lifestyles whose different ecological, physiological and morphological phenotypes reflect the better adaptation of M. duodecimcostatus to the underground habitat. Here we asked whether the differentiation of M. lusitanicus and M. duodecimcostatus involved genetic variations within the tumour suppressor p53 gene, given its role in stress-associated responses. We performed a population-genetic analysis through sequencing of exons and introns of p53 in individuals from sympatric and allopatric populations of both the species in the Iberian Peninsula in which a unidirectional introgression of mitochondrial DNA was previously observed. We were able to discriminate the two species to a large extent. We show that M. duodecimcostatus is composed of one genetically unstructured group of populations sharing a P53 protein that carries a mutation in the DNA-binding region not observed in M. lusitanicus, raising the possibility that this mutation may have been central in the evolutionary history of M. duodecimcostatus. Our results provide suggestive evidence for the involvement of a master transcription factor in the separation of M. lusitanicus and M. duodecimcostatus during Microtus radiation in the Quaternary presumably via a differential adaptive role of the novel p53 in M. duodecimcostatus.

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Section: Dna Extraction P53 Amplification and Sequencingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

p53 gene discriminates two ecologically divergent sister species of pine voles

et al. 2015

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“…Voles in the genus Microtus have been undergoing the fastest radiation known in mammals and diversified into at least 65 species across the world within o2 million years (Jaarola et al, 2004;Fink et al, 2010). Despite very little morphological differentiation, karyotypic variation and differentiation into deep genetic lineages is relatively common within recognized species, suggesting the presence of cryptic species or ongoing speciation processes (Jaarola et al, 2004;Heckel et al, 2005;Hellborg et al, 2005;Bastos-Silveira et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Despite very little morphological differentiation, karyotypic variation and differentiation into deep genetic lineages is relatively common within recognized species, suggesting the presence of cryptic species or ongoing speciation processes (Jaarola et al, 2004;Heckel et al, 2005;Hellborg et al, 2005;Bastos-Silveira et al, 2012). In the common vole (Microtus arvalis), intraspecific divergence has resulted in four main, phenotypically cryptic evolutionary lineages in Europe (Western, Central, Italian and Eastern lineages; Heckel et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Sex-specific clines support incipient speciation in a common European mammal

2013

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Hybrid zones provide excellent opportunities to study processes and mechanisms underlying reproductive isolation and speciation. Here we investigated sex-specific clines of molecular markers in hybrid zones of morphologically cryptic yet genetically highly-diverged evolutionary lineages of the European common vole (Microtus arvalis). We analyzed the position and width of four secondary contact zones along three independent transects in the region of the Alps using maternally (mitochondrial DNA) and paternally (Y-chromosome) inherited genetic markers. Given male-biased dispersal in the common vole, a selectively neutral secondary contact would show broader paternal marker clines than maternal ones. In a selective case, for example, involving a form of Haldane's rule, Y-chromosomal clines would not be expected to be broader than maternal markers because they are transmitted by the heterogametic sex and thus gene flow would be restricted. Consistent with the selective case, paternal clines were significantly narrower or at most equal in width to maternal clines in all contact zones. In addition, analyses using maximum likelihood cline-fitting detected a shift of paternal relative to maternal clines in three of four contact zones. These patterns suggest that processes at the contact zones in the common vole are not selectively neutral, and that partial reproductive isolation is already established between these evolutionary lineages. We conclude that hybrid zone movement, sexual selection and/or genetic incompatibilities are likely associated with an unusual unidirectional manifestation of Haldane's rule in this common European mammal.

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“…The snow voles, genus Chionomys Miller, have earlier been regarded as a part of Microtus Schrank, but their independent generic status has been confirmed by morphological (Nadachowski, 1991;Musser & Carleton, 1993 and references therein) and molecular criteria (Jaarola et al, 2005). The cestode fauna of C. nivalis is dominated by ano- were checked for intestinal helminths.…”

Section: Introductionmentioning

confidence: 99%

Description ofParanoplocephala yoccozin. sp. (Cestoda: Anoplocephalidae) from the snow voleChionomys nivalisin France, with a review of anoplocephalid cestodes of snow voles in Europe

Haukisalmi

Henttonen

2005

Parasite

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Summary :We describe Paranoplocephala yoccozi n. sp. (Cestoda: Anoplocephalidae) from the snow vole Chionomys nivalis in Bourg-Saint-Maurice, French Alps, compare it with several related species from rodents, and review the anoplocephalid cestodes of snow voles in Europe. Paranoplocephala yoccozi n. sp. is primarily distinguished from the related species by its large scolex of characteristic shape, robust neck region, and the structure of the cirrus sac, vitellarium and vagina. We show that the anoplocephalid cestodes of snow voles in Europe, representing the genera Anoplocephaloides and Paranoplocephala, include at least seven species. This fauna consists primarily of species that snow voles share with other voles inhabiting the high-mountain areas. Some of the species, including P. yoccozi n. sp., appear to have a very localized distribution, which is assumed to be a consequence of the historical fragmentation of snow vole populations. Résumé

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Molecular phylogeny of the speciose vole genus Microtus (Arvicolinae, Rodentia) inferred from mitochondrial DNA sequences

Cited by 289 publications

References 56 publications

p53 gene discriminates two ecologically divergent sister species of pine voles

p53 gene discriminates two ecologically divergent sister species of pine voles

Sex-specific clines support incipient speciation in a common European mammal

Description ofParanoplocephala yoccozin. sp. (Cestoda: Anoplocephalidae) from the snow voleChionomys nivalisin France, with a review of anoplocephalid cestodes of snow voles in Europe

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