2011
DOI: 10.2119/molmed.2011.00072
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Molecular Pathways Differentiate Hepatitis C Virus (HCV) Recurrence from Acute Cellular Rejection in HCV Liver Recipients

Abstract: Acute cellular rejection (ACR) and hepatitis C virus (HCV) recurrence (HCVrec) are common complications after liver transplantation (LT) in HCV patients, who share common clinical and histological features, making a differential diagnosis difficult. Fiftythree liver allograft samples from unique HCV LT recipients were studied using microarrays, including a training set (n = 32) and a validation set (n = 19). Two no-HCV-ACR samples from LT recipients were also included. Probe set intensity values were obtained … Show more

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Cited by 27 publications
(28 citation statements)
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References 51 publications
(70 reference statements)
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“…We note that all patients received different combinations of immune-suppressing drugs, including treatment for graft rejection that trended with rapid fibrosis progression at 1 year post-transplant (Table 1). However, we did detect differential regulation of biological processes such as pro-inflammatory innate immune activities and positive regulation of interferon gamma (IFN-γ protein expression and down-stream targets consistent with those described during the transcriptional deregulation associated specifically with HCV recurrence, rather than acute cellular rejection (23). Not surprisingly, patients with progressive liver disease further exhibited an enrichment of differentially regulated proteins mapping to the IPA toxicologic functional category of liver fibrosis, including proteins associated with hepatic stellate cell activation (p < 0.05), and demonstrate the possibility of detecting protein abundance profiles consistent with hepatic damage weeks or months prior to clinical evidence of liver injury.…”
Section: Resultssupporting
confidence: 70%
“…We note that all patients received different combinations of immune-suppressing drugs, including treatment for graft rejection that trended with rapid fibrosis progression at 1 year post-transplant (Table 1). However, we did detect differential regulation of biological processes such as pro-inflammatory innate immune activities and positive regulation of interferon gamma (IFN-γ protein expression and down-stream targets consistent with those described during the transcriptional deregulation associated specifically with HCV recurrence, rather than acute cellular rejection (23). Not surprisingly, patients with progressive liver disease further exhibited an enrichment of differentially regulated proteins mapping to the IPA toxicologic functional category of liver fibrosis, including proteins associated with hepatic stellate cell activation (p < 0.05), and demonstrate the possibility of detecting protein abundance profiles consistent with hepatic damage weeks or months prior to clinical evidence of liver injury.…”
Section: Resultssupporting
confidence: 70%
“…However, when the author created a phage clone expressing TMEM176A and tested it in allogeneic sera (taken from different patients) with hepatitis B virus (HBV)-infected, with head and neck cancer, and healthy normal individuals, the TMEM176A protein was not reactive (Wang et al, 2002). Nevertheless, an increase in human TMEM176A mRNA transcript level has been observed in transplanted human livers that relapsed from hepatitis C virus (HCV) infection (Gehrau et al, 2011). Similarly, an elevated mouse Tmem176A transcript level has been detected in proximal tubule cells of the mouse kidney nephron (Nakajima et al, 2002).…”
Section: Introductionmentioning
confidence: 99%
“…Similar to TMEM176A, the level of human TMEM176B transcripts has been shown to be markedly elevated in transplanted livers that showed recurrence of HCV infection (Gehrau et al, 2011). On the other hand, the mRNA expression of rat Tmem176B (also known as rat TORID, or mouse Clast1/LR8) is highly correlated with tolerated allografts (transplanted tissue taken from a different individual of the same species) (Louvet et al, 2005; Condamine et al, 2010).…”
Section: Introductionmentioning
confidence: 99%
“…However, the implementation of WGE analyses permitted new insights about the molecular biology characterization of certain post-LT complications [13,23,28,37,38]. Furthermore, the extension of this technique to the follow-up of HCV recurrence patients might permit the diagnosis and surveillance of severity in the fibrosis progression, along with pathological evaluation [28].…”
Section: Introductionmentioning
confidence: 99%