Molecular Pathogenesis of Hodgkin Lymphoma: Past, Present, Future

Bienz, Marc; Ramdani, Salima; Knecht, Hans

doi:10.3390/ijms21186623

Cited by 14 publications

(14 citation statements)

References 115 publications

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“…In addition, it has been reported that positivity of EBER-ISH is associated with a high frequency of extranodal involvement in patients with CHL ( 12 ). Reed-Sternberg cells and Hodgkin cells with a rich inflammatory background ensure their survival through the selective recruitment of cells in their microenvironment, constitutional activation of anti-apoptotic pathways, and elaborate evasion of the host immune system ( 13 ). As in the two previous cases ( 9 , 10 ), the present case developed at an advanced age.…”

Section: Discussionmentioning

confidence: 99%

Primary Intramuscular Classic Hodgkin Lymphoma: A Rare Case Report

et al. 2021

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Hodgkin lymphoma (HL) is a hematologic malignancy that typically presents with lymphadenopathy. We herein report a patient with HL who presented with an intramuscular mass that required differentiation from an inflammatory lesion. A 65-year-old Japanese woman was referred to our hospital with a chief complaint of chronic and expanding tumor in her left thigh. By surgical resection, she was diagnosed with primary intramuscular, Epstein-Barr virus-positive, mixed-cellularity classic HL. She received combined modality therapy, resulting in a complete response. Primary intramuscular classic HL is extremely rare. It should be listed as a differential diagnosis of intramuscular tumors.

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Section: Discussionmentioning

confidence: 99%

Primary Intramuscular Classic Hodgkin Lymphoma: A Rare Case Report

et al. 2021

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“…The exact mechanism how early clonal lymphoid precursors (14) are transformed to malignant HRS cells remains elusive. Recent studies show that telomere deprotection likely plays an important role in the evolution of H-cells to RS-cells (15). Disruption in the shelterin protein complex leads to telomere shortening, disorganized chromosome fusions, and ultimately the formation of multinucleated telomere-poor RS cells (Figure 1B).…”

Section: Hodgkin Lymphomamentioning

confidence: 96%

Pathogenesis and Pathology of Pediatric Lymphoma

Li¹

2021

Lymphoma

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“…Finally, a specific NR organization is observed during the differentiation stages of mono-nuclear Hodgkin cells to multi-nucleated Reed-Sternberg cells in classical Hodgkin’s lymphoma ( Contu et al, 2018 ; Bienz et al, 2020 ). Impressive lamin A/C intranuclear septa are seen in bi- to multi-nucleated Reed-Sternberg (RS) cells, where lamin staining showed internal lamin A/C structures, subdividing the nuclei into two or more smaller compartments.…”

Section: Introductionmentioning

confidence: 99%

The Role of Lamins in the Nucleoplasmic Reticulum, a Pleiomorphic Organelle That Enhances Nucleo-Cytoplasmic Interplay

Stiekema

Houben²,

Verheyen³

et al. 2022

Front. Cell Dev. Biol.

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Invaginations of the nuclear membrane occur in different shapes, sizes, and compositions. Part of these pleiomorphic invaginations make up the nucleoplasmic reticulum (NR), while others are merely nuclear folds. We define the NR as tubular invaginations consisting of either both the inner and outer nuclear membrane, or only the inner nuclear membrane. Specifically, invaginations of both the inner and outer nuclear membrane are also called type II NR, while those of only the inner nuclear membrane are defined as type I NR. The formation and structure of the NR is determined by proteins associated to the nuclear membrane, which induce a high membrane curvature leading to tubular invaginations. Here we review and discuss the current knowledge of nuclear invaginations and the NR in particular. An increase in tubular invaginations of the nuclear envelope is associated with several pathologies, such as laminopathies, cancer, (reversible) heart failure, and Alzheimer’s disease. Furthermore, viruses can induce both type I and II NR. In laminopathies, the amount of A-type lamins throughout the nucleus is generally decreased or the organization of lamins or lamin-associated proteins is disturbed. Also, lamin overexpression or modulation of lamin farnesylation status impacts NR formation, confirming the importance of lamin processing in NR formation. Virus infections reorganize the nuclear lamina via (de)phosphorylation of lamins, leading to an uneven thickness of the nuclear lamina and in turn lobulation of the nuclear membrane and the formation of invaginations of the inner nuclear membrane. Since most studies on the NR have been performed with cell cultures, we present additional proof for the existence of these structures in vivo, focusing on a variety of differentiated cardiovascular and hematopoietic cells. Furthermore, we substantiate the knowledge of the lamin composition of the NR by super-resolution images of the lamin A/C and B1 organization. Finally, we further highlight the essential role of lamins in NR formation by demonstrating that (over)expression of lamins can induce aberrant NR structures.

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Molecular Pathogenesis of Hodgkin Lymphoma: Past, Present, Future

Cited by 14 publications

References 115 publications

Primary Intramuscular Classic Hodgkin Lymphoma: A Rare Case Report

Primary Intramuscular Classic Hodgkin Lymphoma: A Rare Case Report

Pathogenesis and Pathology of Pediatric Lymphoma

The Role of Lamins in the Nucleoplasmic Reticulum, a Pleiomorphic Organelle That Enhances Nucleo-Cytoplasmic Interplay

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