2018
DOI: 10.1016/j.jot.2018.05.002
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Molecular pathogenesis of fracture nonunion

Abstract: Fracture nonunion, a serious bone fracture complication, remains a challenge in clinical practice. Although the molecular pathogenesis of nonunion remains unclear, a better understanding may provide better approaches for its prevention, diagnosis and treatment at the molecular level. This review tries to summarise the progress made in studies of the pathogenesis of fracture nonunion. We discuss the evidence supporting the concept that the development of nonunion is related to genetic factors. The importance of… Show more

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Cited by 42 publications
(37 citation statements)
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“…Successful incorporation of allografts to host bone leads to augmentation of osseous restoration by a large margin. Osseous restoration was positively associated with ETO, which can be explained by the fracture healing process caused by ETO, including cytokine secretion and vascular invasion [32,33]. In the allografts group, we found a significant enhancement of femoral width, which reflected the reconstruction of the femoral bone stock through the application of cortical strut allografts.…”
Section: Discussionmentioning
confidence: 71%
See 1 more Smart Citation
“…Successful incorporation of allografts to host bone leads to augmentation of osseous restoration by a large margin. Osseous restoration was positively associated with ETO, which can be explained by the fracture healing process caused by ETO, including cytokine secretion and vascular invasion [32,33]. In the allografts group, we found a significant enhancement of femoral width, which reflected the reconstruction of the femoral bone stock through the application of cortical strut allografts.…”
Section: Discussionmentioning
confidence: 71%
“…Incorporation of cortical strut allografts to host bone was defined as complete union and bridging between them. Fracture nonunion was defined as a persistent fracture line or absence of bridging callus after six postoperative months [32]. Hip function evaluation was conducted by two observers not involved with the surgical and clinical care of the patients using Harris Hip Score (HHS).…”
Section: Methodsmentioning
confidence: 99%
“…The fixation and stability of the cementless femoral component was evaluated according to the criteria of Engh et al [15] Subsidence of the stem was measured as previously described [16]. Radiolucent lines around the stems were divided into seven zones as described by Gruen et al [17] Nonunion of a PFF and ETO were defined as a persistent fracture line or the absence of a bridging callus, respectively, at 6 months postoperative [18]. The incorporation of cortical strut allografts into host bone was defined as complete union and bridging between them.…”
Section: Radiographic Assessmentmentioning
confidence: 99%
“…The fracture line without dislocation is often not obvious in plain radiography at the early stage, which causes a high risk of delays in the diagnosis and treatment, and might lead to scaphoid nonunion. Scaphoid nonunion is frequently seen as a serious bone fracture complication, which remains a challenge in clinical practice [ 2 ]. Some case series of scaphoid fracture reported a nonunion rate of 11–12.3% [ 3 , 4 ].…”
Section: Introductionmentioning
confidence: 99%