Molecular pathogenesis: Connections between viral hepatitis-induced and non-alcoholic steatohepatitis-induced hepatocellular carcinoma

Tian, Zelin; Chen, Xu; Yang, Peijun; Lin, Zhibin; Wu, Wenlong; Zhang, Wenjie; Ding, Jian; Ding, Rui; Zhang, Xuan; Dou, Kefeng

doi:10.3389/fimmu.2022.984728

Cited by 13 publications

(8 citation statements)

References 138 publications

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“…The causes of liver cancer are complex, and viral infection leading to inflammation is one of the most common factors [ 25 ]. First of all, we noted that ZNF385A and ZNF346 were more highly expressed and had higher hazard ratios (HRs) in HBV-infected HCC patients compared to those that were not infected with HBV ( Figures S2 and S5 ), indicating that the two were along with the inflammatory process caused by HBV infection.…”

Section: Discussionmentioning

confidence: 99%

ZNF385A and ZNF346 Serve as Prognostic Biomarkers Associated with an Inflamed Immunosuppressive Tumor Microenvironment in Hepatocellular Carcinoma

Peng

et al. 2023

IJMS

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Hepatocellular carcinoma (HCC) has a high mortality rate worldwide, and there are still many problems in the early diagnosis, molecular targeted therapy, and immunotherapy. It is necessary to explore valuable diagnostic markers and new therapeutic targets in HCC. Zinc finger protein 385A (ZNF385A) and zinc finger protein 346 (ZNF346) represent a unique class of RNA-binding Cys2 His2 (C2H2) zinc finger proteins that are involved in the regulation of cell cycle and apoptosis, but little is known of their roles in HCC. Based on multiple databases and analysis tools, we explored the expression, clinical relation, prognostic value, possible biological function, and pathways of ZNF385A and ZNF346, and their relationship with immune infiltration. Our results revealed that ZNF385A and ZNF346 were highly expressed and were associated with poor prognosis in HCC. Hepatitis B virus (HBV) infection may lead to the overexpression of ZNF385A and ZNF346, which was accompanied by elevated apoptosis and chronic inflammation. Moreover, ZNF385A and ZNF346 were positively correlated with immune-suppressive cells, inflammatory cytokines, immune checkpoint genes, and poor immunotherapy efficacy. Finally, the knockdown of ZNF385A and ZNF346 was observed to negatively affect the proliferation and migration of HepG2 cells in vitro. In conclusion, ZNF385A and ZNF346 are promising candidate biomarkers for the diagnosis, prognosis, and response to immunotherapy in HCC, and this study may help to understand the tumor microenvironment (TME) of liver cancer, and to develop new therapeutic targets.

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Section: Discussionmentioning

confidence: 99%

ZNF385A and ZNF346 Serve as Prognostic Biomarkers Associated with an Inflamed Immunosuppressive Tumor Microenvironment in Hepatocellular Carcinoma

Peng

et al. 2023

IJMS

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“…Meanwhile, HCV and HPV infection were reported as an inducing factor for psoriasis 47–49 . In hepatitis C patients, elevated tumor necrosis factor‐α may cause progression of hepatic disease including NASH and trigger psoriasis in patients with a certain predisposition 47,50,51 . Other researches have uncovered a critical innate immune pathway where RIG‐I‐mediated antiviral response is critical to trigger IL‐23 expression and the development of psoriatic pathology in psoriasis 52 .…”

Section: Discussionmentioning

confidence: 99%

“… 47 , 48 , 49 In hepatitis C patients, elevated tumor necrosis factor‐α may cause progression of hepatic disease including NASH and trigger psoriasis in patients with a certain predisposition. 47 , 50 , 51 Other researches have uncovered a critical innate immune pathway where RIG‐I‐mediated antiviral response is critical to trigger IL‐23 expression and the development of psoriatic pathology in psoriasis. 52 IRF‐3/7, as the predicted TFs for our hub genes, together with NF‐κB being the main downstream signaling pathways of RIG‐I, may promote the production of type I interferon and IFN‐α via pDCs, contributing to initiate psoriasis.…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics analysis to reveal the potential comorbidity mechanism in psoriasis and nonalcoholic steatohepatitis

Xian,

Bai,

Guo

et al. 2023

Skin Research and Technology

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PurposeAn increasing amount of evidence suggests that psoriasis and nonalcoholic steatohepatitis (NASH) may occur simultaneously, whereas the underlying mechanisms remain unclear. Our research aims to explore the potential comorbidity mechanism in psoriasis and nonalcoholic steatohepatitis.Materials and MethodsThe expression profiles of psoriasis (GSE30999, GSE13355) and NASH (GSE24807, GSE17470) were downloaded from GEO datasets. Next, common differently expressed genes (DEGs) of psoriasis and NASH were investigated. Then, GO and KEGG enrichment, protein interaction network (PPI) construction, and hub gene identification for DEGs were performed. Finally, immune cells expression, target genes predicted by common miRNAs, and transcription factors interaction analysis for hub genes were carried out.ResultsTwenty DEGs were identified in totally. GO analysis revealed response to the virus was the most enriched term, and hepatitis C and coronavirus disease‐COVID‐19 infection‐associated pathways were mainly enriched in KEGG. A total of eight hub genes were collected, including IFIT1, IFIT3, OAS1, HPGDS, IFI27, IFI44, CXCL10, IRF9, and 11 TFs were predicted. Then, neutrophils and monocytes were identified as immune cells that express the most hub genes. Moreover, five common miRNAs for psoriasis and NASH and one common miRNAs (hsa‐miR‐1305)‐mRNAs (CHL1, MBNL2) network were presented.ConclusionCHL1 and MBNL2 may participate in the process of psoriasis and NASH via regulating hsa‐miR‐1305, and together with eight hub genes may be potential therapeutic targets for future treatment for the co‐occurrence of these two diseases. This comprehensive bioinformatic analysis provides new insights on molecular pathogenesis and identification of potential therapeutic targets for the co‐occurrence of them.

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“…Epigenetic abnormalities similar to HBV also favor HCV-induced hepatocarcinogenesis. Thus, DNA methylation, histone modifications and microRNAs are also involved in the development of HCC [ 135 ]. LncRNAs and microRNAs similarly contribute to the induction and progression of HCV-associated HCC.…”

Section: Hcc Related To Specific Diseasesmentioning

confidence: 99%

Pathogenesis of Hepatocellular Carcinoma: The Interplay of Apoptosis and Autophagy

2023

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The pathogenesis of hepatocellular carcinoma (HCC) is a multifactorial process that has not yet been fully investigated. Autophagy and apoptosis are two important cellular pathways that are critical for cell survival or death. The balance between apoptosis and autophagy regulates liver cell turnover and maintains intracellular homeostasis. However, the balance is often dysregulated in many cancers, including HCC. Autophagy and apoptosis pathways may be either independent or parallel or one may influence the other. Autophagy may either inhibit or promote apoptosis, thus regulating the fate of the liver cancer cells. In this review, a concise overview of the pathogenesis of HCC is presented, with emphasis on new developments, including the role of endoplasmic reticulum stress, the implication of microRNAs and the role of gut microbiota. The characteristics of HCC associated with a specific liver disease are also described and a brief description of autophagy and apoptosis is provided. The role of autophagy and apoptosis in the initiation, progress and metastatic potential is reviewed and the experimental evidence indicating an interplay between the two is extensively analyzed. The role of ferroptosis, a recently described specific pathway of regulated cell death, is presented. Finally, the potential therapeutic implications of autophagy and apoptosis in drug resistance are examined.

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Molecular pathogenesis: Connections between viral hepatitis-induced and non-alcoholic steatohepatitis-induced hepatocellular carcinoma

Cited by 13 publications

References 138 publications

ZNF385A and ZNF346 Serve as Prognostic Biomarkers Associated with an Inflamed Immunosuppressive Tumor Microenvironment in Hepatocellular Carcinoma

ZNF385A and ZNF346 Serve as Prognostic Biomarkers Associated with an Inflamed Immunosuppressive Tumor Microenvironment in Hepatocellular Carcinoma

Bioinformatics analysis to reveal the potential comorbidity mechanism in psoriasis and nonalcoholic steatohepatitis

Pathogenesis of Hepatocellular Carcinoma: The Interplay of Apoptosis and Autophagy

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