Molecular organization of neuronal cell types and neuromodulatory systems in the zebrafish telencephalon

Anneser, Lukas; Satou, Chie; Hotz, Hans-Rudolf; Friedrich, Rainer W.

doi:10.1016/j.cub.2023.12.003

Cited by 3 publications

(3 citation statements)

References 70 publications

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“…Therefore, both caudo-rostral and medio-lateral gradients involved in hippocampus specification were already present in the last common bony fish ancestor. In agreement with this, transcriptomic studies suggest that the teleost dorsolateral pallium harbors neurons that share molecular signatures with murine hippocampal neurons and other tetrapod homologous regions 25 , 26 .…”

Section: Discussionsupporting

confidence: 64%

“…We also found that, based on their high expression of nr2f1a and nr2f2 , a small proportion of GABAergic neurons likely derives from a homolog of the caudal ganglionic eminence (CGE; inhi_10 and inhi_11). Two recent studies aiming to characterize the teleostean telencephalon independently reached similar conclusions including regarding the potential existence of a previously undescribed CGE homolog with consistent molecular markers and position in the subpallium 25 , 26 .…”

Section: Resultsmentioning

confidence: 63%

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Reconstruction of macroglia and adult neurogenesis evolution through cross-species single-cell transcriptomic analyses

Morizet,

Foucher,

Alunni

et al. 2024

Nat Commun

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Macroglia fulfill essential functions in the adult vertebrate brain, producing and maintaining neurons and regulating neuronal communication. However, we still know little about their emergence and diversification. We used the zebrafish D. rerio as a distant vertebrate model with moderate glial diversity as anchor to reanalyze datasets covering over 600 million years of evolution. We identify core features of adult neurogenesis and innovations in the mammalian lineage with a potential link to the rarity of radial glia-like cells in adult humans. Our results also suggest that functions associated with astrocytes originated in a multifunctional cell type fulfilling both neural stem cell and astrocytic functions before these diverged. Finally, we identify conserved elements of macroglial cell identity and function and their time of emergence during evolution.

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Section: Discussionsupporting

confidence: 64%

Section: Resultsmentioning

confidence: 63%

Reconstruction of macroglia and adult neurogenesis evolution through cross-species single-cell transcriptomic analyses

Morizet,

Foucher,

Alunni

et al. 2024

Nat Commun

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“…In piriform cortex, superficial interneurons receive input primarily from the OB and mediate feed-forward inhibition (FFI) whereas deep interneurons receive input from pyramidal neurons and mediate feedback inhibition (FBI) 44–47 . In zebrafish, pDp contains scattered GABAergic interneurons 37,48 that have not been characterized in detail. It may be expected that precise synaptic balance depends primarily on interneurons mediating FBI, which tracks population activity, but the identity of these interneurons remains to be determined.…”

Section: Introductionmentioning

confidence: 99%

Computational functions of precisely balanced neuronal assemblies in an olfactory memory network

Meissner-Bernard,

Jenkins,

Rupprecht

et al. 2024

Preprint

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Structured connectivity in the brain organizes information by constraining neuronal dynamics. Theoretical models predict that memories are represented by balanced assemblies of excitatory and inhibitory neurons, but the existence and functions of such EI assemblies are difficult to explore. We addressed these issues in telencephalic area Dp of adult zebrafish, the homolog of piriform cortex, using computational modeling, population activity measurements, and optogenetic perturbations. Modeling revealed that precise balance of EI assemblies is important to prevent not only excessive firing rates ("runaway activity") but also the stochastic occurrence of high pattern correlations ("runaway correlations"). Consistent with model-derived predictions, runaway correlations emerged in Dp when synaptic balance was perturbed by optogenetic manipulations of fast-spiking feedback interneurons. Moreover, runaway correlations were driven by sparse subsets of strongly active neurons, rather than by a general broadening of tuning curves. These results reveal novel computational functions of EI assemblies in an autoassociative olfactory memory network and support the hypothesis that EI assemblies organize information on continuous representational manifolds rather than discrete attractor landscapes.

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An atlas and database of neuropeptide gene expression in the adult zebrafish forebrain

Hiraki‐Kajiyama,

Miyasaka,

Ando

et al. 2024

J of Comparative Neurology

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Zebrafish is a useful model organism in neuroscience; however, its gene expression atlas in the adult brain is not well developed. In the present study, we examined the expression of 38 neuropeptides, comparing with GABAergic and glutamatergic neuron marker genes in the adult zebrafish brain by comprehensive in situ hybridization. The results are summarized as an expression atlas in 19 coronal planes of the forebrain. Furthermore, the scanned data of all brain sections were made publicly available in the Adult Zebrafish Brain Gene Expression Database (https://ssbd.riken.jp/azebex/). Based on these data, we performed detailed comparative neuroanatomical analyses of the hypothalamus and found that several regions previously described as one nucleus in the reference zebrafish brain atlas contain two or more subregions with significantly different neuropeptide/neurotransmitter expression profiles. Subsequently, we compared the expression data in zebrafish telencephalon and hypothalamus obtained in this study with those in mice, by performing a cluster analysis. As a result, several nuclei in zebrafish and mice were clustered in close vicinity. The present expression atlas, database, and anatomical findings will contribute to future neuroscience research using zebrafish.

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Molecular organization of neuronal cell types and neuromodulatory systems in the zebrafish telencephalon

Cited by 3 publications

References 70 publications

Reconstruction of macroglia and adult neurogenesis evolution through cross-species single-cell transcriptomic analyses

Reconstruction of macroglia and adult neurogenesis evolution through cross-species single-cell transcriptomic analyses

Computational functions of precisely balanced neuronal assemblies in an olfactory memory network

An atlas and database of neuropeptide gene expression in the adult zebrafish forebrain

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