Molecular Oncology of Gynecologic Tumors

Alvarado‐Cabrero, Isabel

doi:10.1016/j.arcmed.2020.09.001

Cited by 2 publications

(3 citation statements)

References 71 publications

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“…1 Molecular pathology provides excellent guidance for CC in terms of molecular diagnosis and targeted therapy. 27 In contrast to normal cells, tumor cells tend to undergo metabolic reprogramming. Lately, reprogramming of lipid synthesis has been recognized as an important metabolic abnormality required for tumor growth.…”

Section: Discussionmentioning

confidence: 99%

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Reduced 2,4‐dienoyl‐CoA reductase 1 is served as an unfavorable biomarker and is related to immune infiltration in cervical cancer

Guo

Jiang

Deng

et al. 2023

J of Obstet and Gynaecol

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BackgroundWorldwide, cervical cancer (CC) remains the most prevalent malignancy of the female reproductive system, posing a threat to women's life and health, and increasing the medical and economic burden on society. Therefore, the search for tumor biomarkers for CC remains an important research direction. Immunotherapy has significantly improved patient outcomes, and genes related to tumor immune infiltration have been clinically relevant and highly reproducible biomarkers that affect the prognosis and response to treatment of CC. 2,4‐dienoyl‐CoA reductase 1 (DECR1) was considered to be an oncogene in a previous study, but relationship between DECR1 and immune infiltration was not mentioned. Our study aimed to reveal the clinical value of DECR1 in CC and to investigate its relationship with immune infiltration.MethodsHuman Protein Atlas was used to identify the localization of DECR1. The Ualcan database, TCGA, and IHC were used to assess the prognostic value of DECR1. GSEA was used to assess the possible signaling pathways of DECR1 in CC. The TIMER database was applied to reveal the relevance between DECR1 and immune infiltration. GEPIA was conducted to detect the co‐relationship among DECR1, immune markers, and typical molecules of apoptosis.ResultsDECR1 was mainly distributed in the cytoplasm and overlapped with the endoplasmic reticulum. DECR1 was downregulated in CC compared to adjacent tissue. Survival analysis showed that patients with lower expression of DECR1 have a worse prognosis in CC. GSEA suggested that DECR1 was closely related to apoptosis signaling. TIMER showed that DECR1 was positively correlated with CD8+ T cell and CD4+ T cell but not with B cell in CC.ConclusionDECR1 may be a potential cancer suppressor in CC and may be involved in apoptotic pathways and associated with immune infiltration.

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Section: Discussionmentioning

confidence: 99%

“…Despite advances in the diagnosis, treatment, and prevention in CC had achieved, it remains the most prevalent malignancy of the female reproductive system in the world 1 . Molecular pathology provides excellent guidance for CC in terms of molecular diagnosis and targeted therapy 27 …”

Section: Discussionmentioning

confidence: 99%

Reduced 2,4‐dienoyl‐CoA reductase 1 is served as an unfavorable biomarker and is related to immune infiltration in cervical cancer

Guo

Jiang

Deng

et al. 2023

J of Obstet and Gynaecol

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“…Be that as it may, shockingly, the in vivo consequences of NVPBEZ235 are like, or surprisingly better than, the aftereffects of everolimus. Stage I clinical preliminaries GDC0980 and NVPBEZ235 clinical preliminaries have demonstrated the enemy of tumor action in cutting-edge strong tumors [16,17]. The initial segment of the XL765 study was additionally led in patients with cutting-edge strong tumors, and the stage II clinical investigation GDC0980 was directed in patients with lasting or constant endometrial malignancy.…”

Section: Double Pi3k/mtor Inhibitorsmentioning

confidence: 99%

Anti-cancerous medications and PTEN treatment modalities for the control of endometrial malignancy

Pal

Verma²,

Kumar

2022

ijhs

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Endometrial most tumors still up in the air to emerge at Post menopause but at this point its miles been apparent pre-menopause. Unsettling influence in estrogen and progesterone degrees alters the monthly cycle in a regenerative framework. Growing out of and the crazy blast of uterus linage reasons the development of thick covering onto the parts of the uterus which reasons unbalanced draining and distinctive hormonal aggravation incurring most malignancies and diverse digestion unsettling influences. In connection with most diseases, a Lynch disorder, moreover known as Hereditary Non-Polyposis Colorectal Cancer (HNPCC) expands the danger to survivability. Utilization of immunosuppressive specialists, Anti-dangerous Drugs, and inhibitors are stifling utilizing chemotherapy, imaging systems, and radiotherapy which comparatively reasons harm to the cells gift with inside the spot of the attacked cells. Endometrial most malignancies can't be relieved anyway intrusion might be suppressed with the utilization of against carcinogenic pills that have demonstrated unreasonable limit and adequacy with the sickness.

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Molecular Oncology of Gynecologic Tumors

Cited by 2 publications

References 71 publications

Reduced 2,4‐dienoyl‐CoA reductase 1 is served as an unfavorable biomarker and is related to immune infiltration in cervical cancer

Reduced 2,4‐dienoyl‐CoA reductase 1 is served as an unfavorable biomarker and is related to immune infiltration in cervical cancer

Anti-cancerous medications and PTEN treatment modalities for the control of endometrial malignancy

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