Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling

Abstract

SAGE analysis reveals spatiotemporally regulated transcripts and overlapping sense and antisense transcripts that are important for mouse cerebral cortex development

Orchestration of Neuronal Differentiation and Progenitor Pool Expansion in the Developing Cortex by SoxC Genes

“…Sox11 and Sox4 affect neuronal differentiation in all brain regions studied (Hoser et al, 2008;Ling et al, 2009;Mu et al, 2012;Shim et al, 2012). Results presented here extend these findings to the cerebral cortex.…”

Sox4-mediated caldesmon expression facilitates skeletal myoblast differentiation

“…Cardiac development in Sox4 2/2 mice showed defective outflow tract formation and valve development, thus indicating a role for Sox4 in myogenesis (Schilham et al, 1996). Moreover, Sox4 transcripts have been detected in skeletal myoblasts and in myocardium (Ling et al, 2009;Tomczak et al, 2004). These reports strongly suggest that Sox4 participates in myoblast differentiation.…”

lncRNA expression in the auditory forebrain during postnatal development

“…This is consistent with the expression patterns of pcRNA genes in the auditory forebrain (Hackett et al, 2015), and with studies of lncRNAs in other brain regions (Belgard et al, 2011; Liu et al, 2016). Indeed, numerous studies have found that lncRNA expression patterns vary by brain region (Amaral et al, 2009; Kadakkuzha et al, 2015; Ling et al, 2009; Ling et al, 2011; Lv et al, 2013; Mercer et al, 2008; Ponjavic et al, 2009; Sauvageau et al, 2013; Spigoni et al, 2010; Ziats and Rennert, 2013). In addition, the distributions of many genes are specific to restricted loci, such as cortical layer, cell type, or subcellular compartment (Aprea et al, 2013; Belgard et al, 2011; Kadakkuzha et al, 2015; Korneev et al, 2008; Liu et al, 2016; Mercer et al, 2008; Mercer et al, 2010; Pollard et al, 2006; Sasaki et al, 2008; Sauvageau et al, 2013; Sone et al, 2007; Spigoni et al, 2010; Tochitani and Hayashizaki, 2008).…”

“…Spatially, expression levels may vary substantially between major brain regions (e.g., hippocampus versus cerebral cortex) (Amaral et al, 2009; Kadakkuzha et al, 2015; Ling et al, 2009; Ling et al, 2011; Lv et al, 2013; Mercer et al, 2008; Ponjavic et al, 2009; Sauvageau et al, 2013; Spigoni et al, 2010; Ziats and Rennert, 2013), and also by subdivision or compartment within a region (e.g., cortical layer) (Aprea et al, 2013; Belgard et al, 2011; Kadakkuzha et al, 2015; Mercer et al, 2008; Sasaki et al, 2008; Sauvageau et al, 2013; Spigoni et al, 2010). Spatial specificity is also apparent at the cellular level, where expression may be restricted to subpopulations of neurons, glia, or even subcellular compartments (e.g., nuclei, cytoplasm)(Aprea et al, 2013; Kadakkuzha et al, 2015; Korneev et al, 2008; Liu et al, 2016; Mercer et al, 2008; Mercer et al, 2010; Pollard et al, 2006; Sasaki et al, 2008; Sauvageau et al, 2013; Sone et al, 2007; Tochitani and Hayashizaki, 2008).…”

“…Spatial specificity is also apparent at the cellular level, where expression may be restricted to subpopulations of neurons, glia, or even subcellular compartments (e.g., nuclei, cytoplasm)(Aprea et al, 2013; Kadakkuzha et al, 2015; Korneev et al, 2008; Liu et al, 2016; Mercer et al, 2008; Mercer et al, 2010; Pollard et al, 2006; Sasaki et al, 2008; Sauvageau et al, 2013; Sone et al, 2007; Tochitani and Hayashizaki, 2008). Temporally, lncRNA expression in a given locus (e.g., region, subregion, cell type) often changes over the long course of nervous system development, most notably between key developmental stages or significant events (e.g., the onset of sensory experience) (Amaral et al, 2009; Aprea et al, 2013; Lin et al, 2011; Ling et al, 2009; Ling et al, 2011; Lipovich et al, 2012; Liu et al, 2016; Mercer et al, 2010; Ponjavic et al, 2009; Spigoni et al, 2010; Tarabykin et al, 2001). Accordingly, the roles played by lncRNAs in brain development may well depend on the precise timing and location of a given event.…”