Molecular Networks as Sensors and Drivers of Uterine Receptivity in Livestock

Bauersachs, Stefan; Wolf, Eckhard

doi:10.1002/9780470963012.ch7

Cited by 1 publication

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“…Altogether, these findings make this phase particularly interesting for studying uterine receptivity and embryo-maternal crosstalk. In addition to numerous studies focusing on individual candidate genes or major players in involved signaling pathways (reviewed in References 20,21), several global approaches have been applied in livestock species to get an overview of endometrial gene expression changes during the preimplantation phase (22)(23)(24)(25)(26)(27). Endometrial samples collected on selected days of the preimplantation phase and during the estrous cycle were analyzed with DNA microarrays and by RNA sequencing (RNA-seq) to study gene expression changes associated with recognition of pregnancy, embryo implantation, and uterine receptivity.…”

Section: Introductionmentioning

confidence: 99%

Uterine Responses to the Preattachment Embryo in Domestic Ungulates: Recognition of Pregnancy and Preparation for Implantation

Bauersachs

Wolf²

2015

Annu. Rev. Anim. Biosci.

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The endometrium is a tissue newly evolved with the development of mammalian species. Its main function is the support of embryonic growth and development and the nutrition of the fetus. The species-specific differences in establishment and maintenance of pregnancy make the study of this tissue in various mammalian organisms particularly interesting. With the application of omics technologies to various mammalian species, many systematic studies of endometrial gene expression changes during the phase of establishment of pregnancy have been performed to obtain a global view of regulatory events associated with this biological process. This review summarizes the results of trancriptome studies of bovine, porcine, and equine endometrium. Furthermore, the results are compared between these species and to humans. Because an increasing number of studies suggest an important role of small regulatory RNAs (i.e., microRNAs), recent findings related to the regulation of endometrial functions and the development of the conceptus are presented.

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