Molecular monitoring by CDKN2A/p16INK4A and RB1 gene methylation in breast cancer
Luiz Fernando de Queiroz,
Marcelo Soares da Mota e Silva,
Fernando Colonna Rosman
et al.
Abstract:OBJECTIVE: This prospective study aimed to provide a comprehensive analysis of the methylation status of two pivotal genes, CDKN2A/p16 INK4A (cyclin-dependent kinase inhibitor 2A) and RB1 (retinoblastoma transcriptional corepressor 1), in breast cancer patients. METHODS: Samples were obtained from 15 women diagnosed with breast cancer and who underwent a total mastectomy. DNA was extracted from the tumor, non-tumor tissue, and peripheral blood (circulating cell-free DNA). The methylation pattern of cell-free D… Show more
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