Molecular modeling study of the resistance of PLA to hydrolysis based on the blending of PLLA and PDLA

Karst, David; Yang, Yiqi

doi:10.1016/j.polymer.2006.05.002

Cited by 87 publications

(61 citation statements)

References 32 publications

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“…An amorphous PLA structure was built using a methodology similar to that used to build amorphous structures of PLA [14][15][16] and cellulose [17,18]. The amorphous PLA structure contained 10 poly(L-lactide) chains with a DP of 50 at a density of 1.27 g/cm 3 .…”

Section: Evaluation Of Effect Of Disperse Dye Structurementioning

confidence: 99%

Effect of disperse dye structure on dye sorption onto PLA fiber

Karst

Nama

Yang

2007

Journal of Colloid and Interface Science

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Section: Evaluation Of Effect Of Disperse Dye Structurementioning

confidence: 99%

Effect of disperse dye structure on dye sorption onto PLA fiber

Karst

Nama

Yang

2007

Journal of Colloid and Interface Science

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“…[7,[11][12][13][14] The molecular modeling software MS Modeling 3.0, available from Accelrys, was used. [15] An amorphous structure of cellulose was built using the Amorphous Cell module of MS Modeling 3.0.…”

Section: Molecular Modeling Simulationsmentioning

confidence: 99%

Effect of Structure of Large Aromatic Molecules Grafted onto Cellulose on Hydrolysis of the Glycosidic Linkages

Karst

Yang

2007

Macro Chemistry & Physics

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Molecular modeling is used to explain how grafting various molecules that contain large aromatic structures and different reactive groups onto cellulose dramatically increases the hydrolysis of the glycosidic linkages of cellulose. Hydrolysis is found to increase with the increasing size of the molecule grafted to cellulose, and experiments support this finding. A larger substituent on cellulose increases hydrolysis by causing the hydrolyzed cellulose structure to be more stable compared to hydrolyzed cellulose grafted to a smaller substituent. A larger substituent forms stronger interactions with cellulose and has a greater ability to reduce the mobility of the cleaved cellulose chain to which it is bonded, which allows the cleaved cellulose to form stronger cellulose‐cellulose interactions after hydrolysis. A substituent on the C6 position of cellulose increases hydrolysis to a greater extent than does the same substituent on the C3 or C2 position.magnified image

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“…In sum, our evidence indicates that the nanoparticles contain chains short enough to be fully coated by HSA, so that PLA does not form knots in the nanoparticles. We do not know how the short PLA chains arose, though we suspect that the long and extremely energetic mechanical stresses of the emulsification procedure (20,000 rpm for 15 min) might have shredded the original long chains, by aiding hydrolysis of the PLA (Shih 1995;Karst and Yang 2006).…”

Section: Description Of the Nanoparticlesmentioning

confidence: 99%

Albumin-based nanoparticles as magnetic resonance contrast agents: II. Physicochemical characterisation of purified and standardised nanoparticles

Abdelmoez

Thurner

Wallnöfer

et al. 2010

Histochem Cell Biol

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We are developing a nanoparticulate histochemical reagent designed for histochemistry in living animals (molecular imaging), which should finally be useful in clinical imaging applications. The iterative development procedure employed involves conceptual design of the reagent, synthesis and testing of the reagent, then redesign based on data from the testing; each cycle of testing and development generates a new generation of nanoparticles, and this report describes the synthesis and testing of the third generation. The nanoparticles are based on human serum albumin and the imaging modality selected is magnetic resonance imaging (MRI). Testing the second particle generation with newly introduced techniques revealed the presence of impurities in the final product, therefore we replaced dialysis with diafiltration. We introduced further testing methods including thin layer chromatography, arsenazo III as chromogenic assay for gadolinium, and several versions of polyacrylamide gel electrophoresis, for physicochemical characterisation of the nanoparticles and intermediate synthesis compounds. The high grade of chemical purity achieved by combined application of these methodologies allowed standardised particle sizes to be achieved (low dispersities), and accurate measurement of critical physicochemical parameters influencing particle size and imaging properties. Regression plots confirmed the high purity and standardisation. The good degree of quantitative physicochemical characterisation aided our understanding of the nanoparticles and allowed a conceptual model of them to be prepared. Toxicological screening demonstrated the extremely low toxicity of the particles. The high magnetic resonance relaxivities and enhanced mechanical stability of the particles make them an excellent platform for the further development of MRI molecular imaging.

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Molecular modeling study of the resistance of PLA to hydrolysis based on the blending of PLLA and PDLA

Cited by 87 publications

References 32 publications

Effect of disperse dye structure on dye sorption onto PLA fiber

Effect of disperse dye structure on dye sorption onto PLA fiber

Effect of Structure of Large Aromatic Molecules Grafted onto Cellulose on Hydrolysis of the Glycosidic Linkages

Albumin-based nanoparticles as magnetic resonance contrast agents: II. Physicochemical characterisation of purified and standardised nanoparticles

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