Molecular methylation detection based on terahertz metamaterial technology

Gu, Hongyu; Shi, Chenjun; Wu, Xu; Peng, Yan

doi:10.1039/d0an01062f

Cited by 22 publications

(9 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At present, substance identification with THz technology is mainly based on the fingerprint peaks of compounds. Some studies have indicated that the approach can be combined with chips, algorithms, reagents and other auxiliary means to improve the recognition accuracy [18,[26][27][28][29][30]. However, THz technology has not been effectively applied in actual medical diagnosis or evaluation, because human tissue is a mixture of many substances, and the THz fingerprint spectra of these substances overlap with each other, which interferes with the quantitative analysis of disease markers or key substances.…”

Section: Introductionmentioning

confidence: 99%

Three-step one-way model in terahertz biomedical detection

et al. 2021

Self Cite

View full text Add to dashboard Cite

Terahertz technology has broad application prospects in biomedical detection. However, the mixed characteristics of actual samples make the terahertz spectrum complex and difficult to distinguish, and there is no practical terahertz detection method for clinical medicine. Here, we propose a three-step one-way terahertz model, presenting a detailed flow analysis of terahertz technology in the biomedical detection of renal fibrosis as an example: 1) biomarker determination: screening disease biomarkers and establishing the terahertz spectrum and concentration gradient; 2) mixture interference removal: clearing the interfering signals in the mixture for the biomarker in the animal model and evaluating and retaining the effective characteristic peaks; and 3) individual difference removal: excluding individual interference differences and confirming the final effective terahertz parameters in the human sample. The root mean square error of our model is three orders of magnitude lower than that of the gold standard, with profound implications for the rapid, accurate and early detection of diseases.

show abstract

Section: Introductionmentioning

confidence: 99%

Three-step one-way model in terahertz biomedical detection

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Author details 1 Key Laboratory of Terahertz Optoelectronics, Ministry of Education, Beijing 100048, China. 2 Beijing Key Laboratory of Terahertz Spectroscopy and Imaging, Beijing 100048, China.…”

Section: Acknowledgmentmentioning

confidence: 99%

“…Electromagnetic waves in the terahertz (THz) band have a frequency range of 0.1-10 THz and a wavelength range of 0.03-3 mm. Studies have shown that the characteristic vibration modes of many biological macromolecules correspond to the THz band [1]; consequently, THz waves can be used to detect biological molecules [2][3][4][5][6]. Water plays an important role in the function of biomolecules, and thus, most experiments are performed in the solution state.…”

Section: Introductionmentioning

confidence: 99%

Terahertz Absorption Characteristics of Guar Gum Determined via Microfluidic Technology

Zhang

Wang

Huang

et al. 2021

Preprint

View full text Add to dashboard Cite

The vibrational energy levels of many biomolecules correspond to the terahertz band; thus, terahertz technology can be used to identify these substances. Moreover, as the biological activity of most biomolecules can be observed only in aqueous solution, the characteristics of such biomolecules must be studied in aqueous solution. In this study, a simple microfluidic chip, a temperature control device and a strong electric field device were designed to study the terahertz absorption characteristics of guar gum for different temperatures, concentrations and electric field exposure durations, thus enabling the use of terahertz technology to analyse the characteristics of guar gum.

show abstract

“…The use of metamaterials offers highly sensitive biosensing with THz waves [23][24][25], including the detection of viruses [26,27], bacteria [28], microorganisms [29], DNA [30][31][32], protein [33], and cells [34], and even detectable sensitivities up to several 10 ng ml −1 have been achieved by combining with two-dimensional (2D) materials [35]. However, these studies used dried samples and overlooked the detailed properties of the samples because of far-field THz-wave irradiation, which requires a sensing area larger than the diffraction limit of THz waves.…”

Section: Introductionmentioning

confidence: 99%

I-design terahertz microfluidic chip for attomole-level sensing

2022

View full text Add to dashboard Cite

We developed a nonlinear optical crystal-based compact terahertz (THz)-microfluidic chip with several I-design meta-atoms for attomolar-level sensing of trace amounts of solution samples. The I-design meta-atom consists of a metallic strip with a micometer-sized gap sandwiched by other metallic strips. It is periodically arrayed in a row of 1 × 5 units. A point THz source locally generated by optical rectification at the irradiation spot of a femtosecond-pulse laser beam induces a tightly confined electric-field mode at the gap regions and modifies the resonance frequency when a microchannel fabricated along the space between the metallic strips is filled with solutions. Using this chip, we could detect minute changes in the concentration of trace amounts of ethanol- and glucose-water solutions and mineral water by measuring the shift in the resonance frequencies. A maximum detectable sensitivity of 472 attomoles of solutes was achieved in solutions less than 100 picoliters using an effective sensing area of 0.10 λTHz × 0.57 λTHz, which indicates an improvement of approximately one order of magnitude compared to the performance of existing chips. This technique compactifies THz-microfluidic chips with high sensitivity and would accelerate the development of microfluidics integrated with THz technology, such as lab-on-a-chip devices and THz micro total analysis systems.

show abstract

Molecular methylation detection based on terahertz metamaterial technology

Abstract: Terahertz wave has a good ability to identify biomolecules due to its fingerprint spectrum characteristics. However, the minimum detectable limit of terahertz technology by conventional tablet pressing method is in...

Cited by 22 publications

References 33 publications

Three-step one-way model in terahertz biomedical detection

Three-step one-way model in terahertz biomedical detection

Terahertz Absorption Characteristics of Guar Gum Determined via Microfluidic Technology

I-design terahertz microfluidic chip for attomole-level sensing

Contact Info

Product

Resources

About