Molecular methodology to assess the impact of cancer chemotherapy on the oral bacterial flora: a pilot study

Napeñas, Joel J.; Brennan, Michael T.; Coleman, Shirley; Kent, M. Louise; Noll, Jenene; Frenette, Gary; Nussbaum, Marcy; Mougeot, Jean-Luc; Paster, Bruce J.; Lockhart, Peter B.; Bahrani-Mougeot, Farah K.

doi:10.1016/j.tripleo.2009.11.015

Cited by 56 publications

(52 citation statements)

References 26 publications

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“…Other studies investigated microbiological changes in oral flora among leukemia patients. Systematic reviews of published reports were inconsistent with regard to qualitative or quantitative changes in oral flora during cancer chemotherapy and showed no clear pattern or association between mucositis and oral flora changes (2,22). In contrast, several studies have reported qualitative changes in oral flora during chemotherapy (23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of drug-resistant opportunistic microorganisms in oral cavity after treatment for oral cancer

et al. 2013

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Drug-resistant opportunistic infectionsmay cause health problems in immunocompromised hosts. Representative microorganisms in opportunistic infections of the oral cavity are Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. We investigated the prevalence of drugresistant opportunistic microorganisms in elderly adults receiving follow-up examinations after primary treatment of oral cancer. Oral microorganisms were collected from patients satisfactorily treated for oral cancer (defined as good outcomes to date) and a group of healthy adults (controls). After identification of microorganisms, the prevalence of drug-resistant microorganisms was studied. Pulsedfield gel electrophoresis (PFGE) and staphylococcal cassette chromosome mec (SCCmec) typing were also performed for methicillin-resistant S aureus (MRSA). Statistical analysis revealed no significant differences in the prevalences of the three microorganisms between the groups. Surprisingly, 69.2% of S aureus isolates showed oxacillin resistance, suggesting that MRSA colonization is increasing among older Japanese. These MRSA isolates possessed SCCmec types II and IV but no representative toxin genes. Our results indicate that a basic infection control strategy, including standard precautions against MRSA, is important for elderly adults, particularly after treatment for oral cancer. (J Oral Sci 55, [145][146][147][148][149][150][151][152][153][154][155] 2013)

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Section: Discussionmentioning

confidence: 99%

Prevalence of drug-resistant opportunistic microorganisms in oral cavity after treatment for oral cancer

et al. 2013

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“…Furthermore, shifts in oral bacterial flora (mainly from streptococci toward coagulase-positive staphylococci) [130]) have been attributed to CT, xerostomia, antibiotic use and associated neutropenia [130][131][132].…”

Section: -The Evaluation Of the Suspected Infection Sourcementioning

confidence: 99%

Sepsis in head and neck cancer patients treated with chemotherapy and radiation: Literature review and consensus

Mirabile

Numico²,

Russi

et al. 2015

Critical Reviews in Oncology/Hematology

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The reporting of infection/sepsis in chemo/radiation-treated head and neck cancer patients is sparse and the problem is underestimated. A multidisciplinary group of head and neck cancer specialists from Italy met with the aim of reaching a consensus on a clinical definition and management of infections and sepsis. The Delphi appropriateness method was used for this consensus. External expert reviewers then evaluated the conclusions carefully according to their area of expertise. The paper contains seven clusters of statements about the clinical definition and management of infections and sepsis in head and neck cancer patients, which had a consensus. Furthermore, it offers a review of recent literature in these topics

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“…Their impact on the oral mucosa was reported thereafter [61]. Additional studies have continued to investigate shifts in the ecological balance of the oral and gut flora following anti-cancer treatment [16,17,[62][63][64][65][66].…”

Section: Microbiome Changesmentioning

confidence: 99%

“…A recent study by Napenas and colleagues (2010) studied the profile of the oral bacterial flora following anthracycline therapy in an outpatient cancer population. They found that over 60 % of bacterial flora identified on patients' buccal mucosa was exclusively seen postchemotherapy suggesting an alteration in the nature of oral flora [65]. Shifts in oral bacterial flora in cancer patients have also been attributed to antibiotic use [70], neutropenia [71] and xerostomia [70].…”

Section: Microbiome Changesmentioning

confidence: 99%

Emerging evidence on the pathobiology of mucositis

Al‐Dasooqi

Sonis

Bowen

et al. 2013

Support Care Cancer

168

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Background Considerable progress has been made in our understanding of the biological basis for cancer therapyinduced mucosal barrier injury (mucositis). The last formal review of the subject by MASCC/ISOO was published in 2007; consequently, an update is timely. Methods Panel members reviewed the biomedical literature on mucositis pathobiology published between January 2005 and December 2011.Results Recent research has provided data on the contribution of tissue structure changes, inflammation and microbiome changes to the development of mucositis. Additional research has focused on targeted therapyinduced toxicity, toxicity clustering and the investigation of genetic polymorphisms in toxicity prediction. This review paper summarizes the recent evidence on these aspects of mucositis pathobiology. Conclusion The ultimate goal of mucositis researchers is to identify the most appropriate targets for therapeutic interventions and to be able to predict toxicity risk and personalize interventions to genetically suitable patients. Continuing research efforts are needed to further our understanding of mucositis pathobiology and the pharmacogenomics of toxicity.

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Molecular methodology to assess the impact of cancer chemotherapy on the oral bacterial flora: a pilot study

Cited by 56 publications

References 26 publications

Prevalence of drug-resistant opportunistic microorganisms in oral cavity after treatment for oral cancer

Prevalence of drug-resistant opportunistic microorganisms in oral cavity after treatment for oral cancer

Sepsis in head and neck cancer patients treated with chemotherapy and radiation: Literature review and consensus

Emerging evidence on the pathobiology of mucositis

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