Molecular mediators and controlling mechanism of vascular calcification

Melaku, Leta; Mossie, Andualem

doi:10.4103/ijcep.ijcep_3_17

Cited by 7 publications

(4 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The classically held view that mineralization is a passive, degenerative process must be dispelled nowadays as it turns out to be actively regulated akin to bone mineralization. 59,60 Regardless of the primarily altered blood electrolyte(s) in rats (Ca, IP, or both), the resulting histomorphological picture remains the same and is in accordance with the pattern described above.…”

Section: Monovalent Fgfr1-antagonist Induced Metastatic Mineralizatio...supporting

confidence: 74%

See 1 more Smart Citation

Proceedings of the 2020 Classic Examples in Toxicologic Pathology XXVII

et al. 2021

View full text Add to dashboard Cite

The histopathology slide seminar “Classic Examples in Toxicologic Pathology XXVII” was held on February 21 and 22, 2020, at the Department of Pathology at the University of Veterinary Medicine in Hannover, Germany, with joint organization by the European Society of Toxicologic Pathology. The goal of this annual seminar is to present and discuss classical and actual cases of toxicologic pathology. This article summarizes the presentations given during the seminar, including images of representative lesions. Ten actual and classical cases of toxicologic pathology, mostly induced by a test article, were presented. These included small intestine pathology and transcriptomics induced by a γ-secretase modulator, liver findings in nonhuman primates induced by gene therapy, drug-induced neutropenia in dogs, device-induced growth plate lesions, polycystic lesions in CAR/PXR double knockout mice, inner ear lesions in transgenic mice, findings in Beagle dogs induced by an inhibitor of the myeloid leukemia cell differentiation protein MCL1, findings induced by a monovalent fibroblast growth factor receptor 1 antagonist, kidney lesions induced by a mammalian target of rapamycin inhibitor in combination therapy, and findings in mutation-specific drugs.

show abstract

Section: Monovalent Fgfr1-antagonist Induced Metastatic Mineralizatio...supporting

confidence: 74%

“…The classically held view that mineralization is a passive, degenerative process must be dispelled nowadays as it turns out to be actively regulated akin to bone mineralization. 59,60…”

Section: Monovalent Fgfr1-antagonist Induced Metastatic Mineralizatio...mentioning

confidence: 99%

Proceedings of the 2020 Classic Examples in Toxicologic Pathology XXVII

et al. 2021

View full text Add to dashboard Cite

show abstract

“…• увеличении продукции эндотелиального оксида азота (NO), • уменьшении адгезии и агрегации тромбоцитов, • снижении окислительного стресса, • регуляции мышечного тонуса сосудов, • уменьшении выделения вазоконстриктивных метаболитов, • подавлении высвобождения провоспалительных цитокинов, • модулировании иммунного ответа, • ингибировании пролиферации и миграции гладкомышечных клеток. В экспериментальных исследованиях доказано, что активный метаболит витамина D -1,25(ОН)2D уменьшает отложение минеральных депозитов во внутренней оболочке артерий, регулирует содержание в сыворотке крови кальция и фосфора [9][10][11]. Увеличение жесткости сосудистой стенки является важным фактором в развитии атеросклероза.…”

Section: âèòàìèí D è ðàçâèòèå àòåðîñêëåðîçàunclassified

Vitamin D deficiency and cardiovascular pathology

Подзолков

Pokrovskaya

Панасенко

2018

Terapevticheskii arkhiv

View full text Add to dashboard Cite

Vitamin D deficiency is widespread worldwide and present in about 30-50% of population. In most cases, this problem is associated with musculoskeletal system pathology: rickets in children, and osteomalacia or osteoporosis in adults. However, in recent years, convincing data was obtained on the links between vitamin D deficiency and cardiovascular pathology. Low Vitamin D levels in humans are associated with the unfavorable cardiovascular risk factors, such as arterial hypertension (AH), diabetes mellitus, and dyslipidemia, which are the predictors of the severe cardiovascular diseases, including strokes and infarctions. It has been demonstrated that vitamin D has a strong vasoptotective effect via endothelial dysfunction improvement, prevents blood vessels and myocardium remodeling, improves blood pressure parameters, reduces the risk of development of left ventricular hypertrophy, slows down fibrosis, reduces the risk of atherosclerosis, reduces insulin resistance, and also affects inflammation and immunity. This article provides data of Russian and foreign studies demonstrating the effect of Vitamin D deficiency on the development of atherosclerosis, AH, heart rhythm disorder and progression of chronic heart failure.

show abstract

“… 26 Given to its interaction with and neutralizing apoptotic factor TRAIL, it is considered as an anti-apoptotic factor, therefore, OPG acts as anti-calcifying agent in this background. 26 , 27 Studies show that OPG is the key regulator of bone remodeling by inhibition of interaction between RANKL, a specific receptor of RANK on cell surface. While the underlying molecular basis of signaling pathways in VC are not fully understood it has been shown that OPG deficient (OPG−/−) mouse models display calcification in renal arteries and aorta and also a reduction in bone mass accompanied by early onset osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

Vascular calcification; Stony bridge between kidney and heart

Zaker

Ardalan

2020

J Cardiovasc Thorac Res

View full text Add to dashboard Cite

Vascular calcification is a high prevalent complication that arises as a consequence of impaired calcium and phosphate balance amongst cardiovascular patients. Multiple inducer/ inhibitory molecules and pathways as well as genetic background and lifestyle play role in this phenomenon. According to which vessel layer (intima, media or both) is involved different types of vascular calcification take place. Actual mechanism and consensus pathways have not been elucidated yet and needs further investigations.

show abstract

Molecular mediators and controlling mechanism of vascular calcification

Cited by 7 publications

References 4 publications

Proceedings of the 2020 Classic Examples in Toxicologic Pathology XXVII

Proceedings of the 2020 Classic Examples in Toxicologic Pathology XXVII

Vitamin D deficiency and cardiovascular pathology

Vascular calcification; Stony bridge between kidney and heart

Contact Info

Product

Resources

About