Molecular mechanisms underlying chronic inflammation-associated cancers

Wu, Yongzhong; Antony, Smitha; Meitzler, Jennifer L.; Doroshow, James H.

doi:10.1016/j.canlet.2013.08.014

Cited by 246 publications

(198 citation statements)

References 148 publications

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“…On the other hand, Nox-derived ROS can oxidize redox-sensitive cysteine residues in the catalytic domain of PTPs and inactivate their ability to limit the propagation of cytokine-derived signals. ROS can also directly oxidize the cysteine residues in some TFs and regulate their transcriptional activity [35].…”

Section: Immune Complex Mediates Chronic Inflammationmentioning

confidence: 99%

Persistent Circulating Immune Complexes: Potential Source of Epimutation and Cancer Poor Prognosis

Ezeani¹,

Onyenekwe²,

Meludu³

2017

IJGG

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Abstract:Estimation of serum level of circulating immune complexes and its use for monitoring treatments have been carried out extensively in various disease conditions including autoimmune diseases and cancer, but little or no work has considered persistent circulation of immune complexes consequent to physiological anomalies that could mediate epimutation and subsequent epigenetic cell alteration and tumourigenesis. This review looked into the immuno-physiological activities of circulating immune complexes to expose its possible epigenomic consequences and potential role in epimutation. The environmental link between epigenetic cell alteration and formation of circulating immune complexes makes this review a unique one but on the other hand, gives room for concern. Immune complexes have strong capacity to stimulate various immune responses, yet the immunological activities of these circulating immune complexes are over looked or under estimated. Immune complexes is a normal immunological phenomenon but its persistence and subsequent deposition could induce endogenous assaults that would continuously and adversely perturb the epigenomic activities by fuelling chronic inflammation, activating transcription factors (NFkB), generation of reactive oxygen species (ROS) and frequent release of cytokines leading to epigenetic cell alteration especially in developing countries where environmental pollution is a serious factor.

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Section: Immune Complex Mediates Chronic Inflammationmentioning

confidence: 99%

Persistent Circulating Immune Complexes: Potential Source of Epimutation and Cancer Poor Prognosis

Ezeani¹,

Onyenekwe²,

Meludu³

2017

IJGG

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“…Some of these factors are transforming growth factor (TGF)-β, IL-10, epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), matrix metalloproteinases (MMPs), collagen, extracellular matrix (ECM) glycans, etc. [21][22][23][24]. Moreover, colitis was found to be associated with inflammatory response mediated by T helper (Th)1 and Th17 immune response.…”

Section: Immune System Related Markersmentioning

confidence: 99%

Potential markers for early diagnostics of Colorectal cancer and Inflammatory bowel disease in humans : intestinal microorganisms and immune system (teammates or rivals)

Horák¹,

Kučerová²,

Červinková³

2017

Can J Biotech

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| P a g e AbstractChronic inflammation of the bowel is the characteristic of Inflammatory bowel diseases including Ulcerative colitis and Crohn's disease. The incidence of Inflammatory bowel disease (IBD) in Western Europe is 14/100,000 of inhabitants. Duration and severity of inflammation increases the risk of Colorectal cancer (CRC) development by about 60% in IBD patients. CRC is the 3 rd most common type of tumor in Western population. Every year, more than one million new cases are diagnosed with more than 600,000 deaths.The early detection of CRC, originating from any part of the colon-rectum, is desirable because it can be cured surgically if diagnosed timely. Identification of new early markers for IBD and CRC is very important.This review deals with the searching and identification of possibly new early markers for the above mentioned pathologies. We have focused on intestinal microorganisms (changes in qualitative and quantitative composition of microbiome, selection of candidate microorganisms) and immune system markers (cytokines, chemokines, nuclear factor B, Toll-like receptors andReceptor for Advanced Glycation End Products).

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“…This is achieved by modifying the architecture of the fibrous scaffold and the characteristics of the ECM [3,28,36]. Increased TGF-β1 was shown to inhibit the proliferation and function of lymphatic endothelial cells [37].…”

Section: Tgf-β and Lox Regulate Tissue Structure And Stiffnessmentioning

confidence: 99%

“…This includes blood and lymphatic vessels, fibroblasts and extracellular matrix (ECM) components, nerves, immune cells infiltrating the tumor [1,2] and normal tissue cells within which a developing cancer cell clone can expand. In addition, both normal and tumor cells release soluble products that affect both local, as well as systemic conditions within a cancer-bearing subject [3]. These soluble products include cytokines, chemokines, ROS, growth factors, enzymes and other products.…”

Section: Introductionmentioning

confidence: 99%

Stroma as an Active Player in the Development of the Tumor Microenvironment

Vannucci

2014

Cancer Microenvironment

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The stroma is a considerable part of the tumor microenvironment. Because of its complexity, it can influence both cancer and immune cells in their behavior and cross-talk. Aside from soluble products released by non-cancer and cancer cells, extracellular matrix components have been increasingly recognized as more than just minor players in the constitution, development and regulation of the tumor microenvironment. The variations in the connective scaffold architecture, induced by transforming growth factor beta, lysyl oxidase and metalloproteinase activity, create different conditions of ECM density and stiffness. They exert broad effects on immune cells (e.g. physical barriers, modulation by release of stored TGF-β1), mesenchymal cells (transition to myofibroblasts), epithelial cells (epithelial-to-mesenchymal transition), cancer cells (progression to metastatic phenotype) and stem cells (activation of differentiation addressed by the microenvironment characteristics). Physiological mechanisms of the wound healing process, as well as mechanisms of fibrosis in some chronic pathologies, closely recall aspects of cancer deregulated biology. Their elucidation can provide a better understanding of tumor microenvironment immunobiology. In the following short review, we will focus on some aspects of the fibrous stroma to highlight its active participation in the tumor microenvironment constitution, tumor progression and the local immunological network.

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Molecular mechanisms underlying chronic inflammation-associated cancers

Cited by 246 publications

References 148 publications

Persistent Circulating Immune Complexes: Potential Source of Epimutation and Cancer Poor Prognosis

Persistent Circulating Immune Complexes: Potential Source of Epimutation and Cancer Poor Prognosis

Potential markers for early diagnostics of Colorectal cancer and Inflammatory bowel disease in humans : intestinal microorganisms and immune system (teammates or rivals)

Stroma as an Active Player in the Development of the Tumor Microenvironment

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