Molecular Mechanisms Through Which Cannabidiol May Affect Skeletal Muscle Metabolism, Inflammation, Tissue Regeneration, and Anabolism: A Narrative Review

Schouten, Moniek; Dalle, Sebastiaan; Koppo, Katrien

doi:10.1089/can.2022.0220

Cited by 9 publications

(5 citation statements)

References 108 publications

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“…Although the molecular pathways and mechanisms through which CBD acts have not been fully established yet ( Batalla et al, 2020 ), it is suggested that CBD can directly interact with different receptor-dependent and independent mechanisms ( Schouten et al, 2022 ), thereby targeting multiple pathways and mechanisms of action which contribute to different therapeutic applications ( Britch et al, 2021 ; Legare et al, 2022 ) (see Figure 1 ). CBD engages in the activation of channels (e.g., TRPV1), transcription factors (e.g., PPARγ), and different GPCRs, such as CB1, CB2, GPR55, serotonin 1A receptor (5-HT1A), and adenosine A2a receptor.…”

Section: Cbd and The Endocannabinoid Systemmentioning

confidence: 99%

Cannabidiol and brain function: current knowledge and future perspectives

Schouten,

Dalle,

Mantini

et al. 2024

Front. Pharmacol.

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Cannabidiol (CBD) is a naturally occurring non-psychoactive cannabinoid found in Cannabis sativa, commonly known as cannabis or hemp. Although currently available CBD products do not meet the safety standards of most food safety authorities to be approved as a dietary supplement or food additive, CBD has been gaining widespread attention in recent years due to its various potential health benefits. While primarily known for its therapeutic effects in managing epileptic seizures, psychosis, anxiety, (neuropathic) pain, and inflammation, CBD’s influence on brain function has also piqued the interest of researchers and individuals seeking to enhance cognitive performance. The primary objective of this review is to gather, synthesize, and consolidate scientifically proven evidence on the impact of CBD on brain function and its therapeutic significance in treating neurological and mental disorders. First, basic background information on CBD, including its biomolecular properties and mechanisms of action is presented. Next, evidence for CBD effects in the human brain is provided followed by a discussion on the potential implications of CBD as a neurotherapeutic agent. The potential effectiveness of CBD in reducing chronic pain is considered but also in reducing the symptoms of various brain disorders such as epilepsy, Alzheimer’s, Huntington’s and Parkinson’s disease. Additionally, the implications of using CBD to manage psychiatric conditions such as psychosis, anxiety and fear, depression, and substance use disorders are explored. An overview of the beneficial effects of CBD on aspects of human behavior, such as sleep, motor control, cognition and memory, is then provided. As CBD products remain largely unregulated, it is crucial to address the ethical concerns associated with their use, including product quality, consistency, and safety. Therefore, this review discusses the need for responsible research and regulation of CBD to ensure its safety and efficacy as a therapeutic agent for brain disorders or to stimulate behavioral and cognitive abilities of healthy individuals.

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Section: Cbd and The Endocannabinoid Systemmentioning

confidence: 99%

Cannabidiol and brain function: current knowledge and future perspectives

Schouten,

Dalle,

Mantini

et al. 2024

Front. Pharmacol.

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“…Also, the relevance of cannabis (and here especially the active ingredient delta‐9‐tetrahydrocannabinol, THC) as a doping agent has continued to be subject of controversial positions 155,156 . The 2023 and 2024 editions of the Prohibited List remained unchanged as to the status of THC and cannabinoids in general, 21,153 with cannabidiol (CBD) being explicitly excluded from the banned category in virtue of its molecular mechanisms of action 157 . Athletes might be at risk of (unknowingly) ingesting THC‐containing products as reported by Wagner et al, for example, when consuming milk from hemp‐fed dairy cows 100 .…”

Section: Glucocorticoids Cannabinoids and Beta‐blockersmentioning

confidence: 99%

Annual banned‐substance review 16^th edition—Analytical approaches in human sports drug testing 2022/2023

Thevis,

Kuuranne,

Geyer

2023

Drug Testing and Analysis

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In this 16th edition of the annual banned‐substance review on analytical approaches in human sports drug testing, literature on recent developments in this particular section of global anti‐doping efforts that was published between October 2022 and September 2023 is summarized and discussed. Most recent additions to the continuously growing portfolio of doping control analytical approaches and investigations into analytical challenges in the context of adverse analytical findings are presented, taking into account existing as well as emerging challenges in anti‐doping, with specific focus on substances and methods of doping recognized in the World Anti‐Doping Agency's 2023 Prohibited List. As in previous years, focus is put particularly on new or enhanced analytical options in human doping controls, appreciating the exigence and core mission of anti‐doping and, equally, the conflict arising from the opposingly trending extent of the athlete's exposome and the sensitivity of instruments nowadays commonly available in anti‐doping laboratories.

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“…60 Se han realizado estudios en investigación en ratones con respecto a la expresión diferencial de los receptores de cannabinoides CB1 y CB2 y ha destacado que la expresión de CB2 mejora con el ejercicio al promover la capacidad regenerativa del músculo mediada por Pax7 y MyoD, lo cual alienta a explorar el CBD en el tratamiento de la sarcopenia en este grupo de pacientes. 61…”

Section: Efectos Del Tratamiento Paliativo Y Otros Tratamientosunclassified

El músculo y el cáncer: una relación bidireccional. Fisiopatología y consecuencias

León-Reyes,

Canto,

Coral-Vázquez

2023

Investigación en Discapacidad

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ResumenEl músculo cuenta con interrelaciones muy importantes con otros órganos como el corazón, hígado, cerebro y tejido adiposo. Su desgaste, conocido como sarcopenia, se ha asociado a los diferentes tipos de cáncer durante el tratamiento, lo que condiciona incremento de la toxicidad derivada tanto de la quimioterapia como de la radioterapia. Lo anterior provoca retrasos del tratamiento y ajustes no deseados de las dosis del mismo que impactan negativamente la supervivencia de los pacientes con cáncer. Existe evidencia que sugiere que la sarcopenia persiste aún en la etapa de supervivencia condicionando un impacto negativo en la calidad de vida de los pacientes y en su productividad laboral. Se conocen diferentes mecanismos fisiopatológicos a nivel celular y molecular involucrados en la sarcopenia en el cáncer que muestran cada vez con mayor claridad una relación bidireccional tanto positiva como negativa entre el cáncer y el músculo.

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Molecular Mechanisms Through Which Cannabidiol May Affect Skeletal Muscle Metabolism, Inflammation, Tissue Regeneration, and Anabolism: A Narrative Review

Cited by 9 publications

References 108 publications

Cannabidiol and brain function: current knowledge and future perspectives

Cannabidiol and brain function: current knowledge and future perspectives

Annual banned‐substance review 16^th edition—Analytical approaches in human sports drug testing 2022/2023

El músculo y el cáncer: una relación bidireccional. Fisiopatología y consecuencias

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Molecular Mechanisms Through Which Cannabidiol May Affect Skeletal Muscle Metabolism, Inflammation, Tissue Regeneration, and Anabolism: A Narrative Review

Cited by 9 publications

References 108 publications

Cannabidiol and brain function: current knowledge and future perspectives

Cannabidiol and brain function: current knowledge and future perspectives

Annual banned‐substance review 16th edition—Analytical approaches in human sports drug testing 2022/2023

El músculo y el cáncer: una relación bidireccional. Fisiopatología y consecuencias

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Product

Resources

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Annual banned‐substance review 16^th edition—Analytical approaches in human sports drug testing 2022/2023