Molecular mechanisms regulating NLRP3 inflammasome activation

Jo, Eun-Kyeong; Kim, Jin‐Kyung; Shin, Dong–Min; Sasakawa, Chihiro

doi:10.1038/cmi.2015.95

Cited by 1,014 publications

(784 citation statements)

References 140 publications

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“…A number of studies have demonstrated that IL-1β mediates depressive-like behaviors induced by stress as well as proinflammatory challenges, which of course implicates a mechanistic role for inflammasomes because inflammasomes mediate, in large part, the processing and maturation of IL-1β (Jo et al, 2016). Further, when administered to naive animals, IL-1β is sufficient to induce depressive-like behaviors (Goshen et al, 2009).…”

Section: Animal Models Of Depression: Role Of Inflammasomesmentioning

confidence: 99%

Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

Fleshner

Frank

Maier

2016

Neuropsychopharmacol

164

120

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Major depressive disorder (MDD) and other mood disorders remain difficult to effectively treat, and innovative interventions and therapeutic targets are needed. Psychological stressors and inappropriate inflammation increase the risk and severity of mood disorders; however, only recently have the importance of sterile inflammatory processes in this effect been revealed. This review will introduce the reader to pathogen vs sterile inflammation, inflammatory receptor-ligand interactions, microbialassociated molecular patterns (MAMPs), pathogen-associated molecular patterns (PAMPs), danger-associated molecular patterns (DAMPs), and the more recent discovery of the role of the inflammasome in peripheral and central nervous system cytokine/chemokine inflammatory responses. The review will focus on current preclinical and clinical evidence that sterile inflammation and inflammasome-dependent signaling may contribute to mood disorders. By understanding these inflammatory signaling processes, new approaches for quieting chronic or inappropriate inflammatory states may be revealed and this could serve as novel pharmacological targets for the treatment of mood disorders.

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Section: Animal Models Of Depression: Role Of Inflammasomesmentioning

confidence: 99%

Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

Fleshner

Frank

Maier

2016

Neuropsychopharmacol

164

120

View full text Add to dashboard Cite

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“…In addition, recent research work shows the implication of inflammasomes in the induction of programmed cell death, such as apoptosis via recruit procaspase-8 [107]. Inflammasomes have now been described in details, and are reviewed elsewhere [108][109][110][111]. Inflammasomes counter parasite replication and clear infected cells through an inflammatory cell death program termed pyroptosis.…”

Section: Inflammasome-mediated Pyroptotic and Apoptotic Cell Death (Pmentioning

confidence: 99%

Cell death offers exceptional cellular and molecular windows for pharmacological interventions in protozoan parasites

El‐Ashram¹,

Mehmood²,

Dinçel³

et al. 2017

Integr Mol Med

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The rich repertoire of cell death events is a crucial biological process that deserves extensive review at a formative time for the development of our knowledge concerning the state-of-the-art data on their cellular and molecular mechanisms of action and the ways in which they can be manipulated in and by protozoan parasites. We have attempted to provide a comprehensive overview to reveal intervention points that could be exploited to discover novel therapies, vaccine strategies and prophylactic intervention points for protozoan parasites, and to understand the parasitic disease progression and the infection consequence.

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“…84,85 PYD-only protein POP3 competes with ASC to bind AIM2-like receptors (ALRs), thus acting as an inhibitor of DNA virus-induced activation of ALR inflammasomes in monocytes and macrophages. 86,87 Neurotransmitter dopamine (DA)/dopamine D1 receptor (DRD1) signaling pathway negatively regulate NLRP3 inflammasome activation and NLRP3-dependent systemic inflammation via a second messenger cyclic adenosine monophosphate, which binds to NLRP3 and promotes its ubiquitination and degradation via the E3 ubiquitin ligase MARCH7.…”

Section: Molecular Regulation Of Innate Immunity and Inflammationmentioning

confidence: 99%