Molecular mechanisms of the chemical constituents from anti-inflammatory and antioxidant active fractions of Ganoderma neo-japonicum Imazeki

Zhang, Jing; Guo, Xingzhong; Chen, Yingying; Sun, Jinyue; Miao, Jia-lin; Carpena, M.; Prieto, Miguel A.; Li, Ningyang; Zhou, Qingxin; Liu, Chao

doi:10.1016/j.crfs.2023.100441

Cited by 4 publications

(1 citation statement)

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“…As a source of distinctive bioactive metabolites, which grants it a number of attributes, it has been demonstrated to be efficient in the treatment and management of a variety of diseases [4]. G. lucidum has demonstrated potent anticancer [5,6], anti-inflammatory [7], hepatoprotective [8], antidiabetic [9], cardioprotective [10], immunomodulatory [11], antioxidant [12], and antiaging [13] activities. Due to its distinct potential as a medicine, there is increased demand in the food sector for it to be used as a significant source for nutrient supplements [14].…”

Section: Introductionmentioning

confidence: 99%

Ganoderma lucidum: Novel Insight into Hepatoprotective Potential with Mechanisms of Action

Ahmad

Zeyaullah

et al. 2023

Nutrients

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Ganoderma lucidum (G. lucidum) has been widely used for its health benefits as an edible and traditional medicinal mushroom for thousands of years in Asian countries. It is currently used as a nutraceutical and functional food owing to its major bioactive compounds, polysaccharides and triterpenoids. G. lucidum exhibits a broad range of hepatoprotective impacts in various liver disorders, such as hepatic cancer, nonalcoholic fatty liver disease (NAFLD), alcohol-induced liver disease, hepatitis B, hepatic fibrosis, and liver injury induced by carbon tetrachloride (CCl4) and α-amanitin. G. lucidum protects the liver through a broad range of mechanisms that include the modulation of liver Phase I and II enzymes, the suppression of β-glucuronidase, antifibrotic and antiviral actions, the regulation of the production of nitric oxide (NO), the maintenance of hepatocellular calcium homeostasis, immunomodulatory activity, and scavenging free radicals. G. lucidum could signify an encouraging approach for the management of various chronic hepatopathies, and its potential mechanisms make it a distinctive agent when used alone or with other drugs and applied as a functional food, nutraceutical supplement, or adjuvant to modern medicine. This review summarizes the hepatoprotective properties of G. lucidum with its various mechanisms of action on different liver ailments. Biologically active substances derived from G. lucidum are still being studied for their potential benefits in treating different liver ailments.

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