Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer

Cotino-Nájera, Sandra; Herrera, Luis A.; Domínguez-Gómez, Guadalupe; Díaz-Chávez, José

doi:10.3389/fphar.2023.1287505

Cited by 5 publications

(2 citation statements)

References 316 publications

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“…Remarkably decreased IL-1β levels in a study indicated that probiotics reduce inflammatory factor levels ( Wang et al, 2012 ). Additionally, TNF-α, a key inflammatory cytokine that regulates classical NF-κB inflammatory pathway activation, acts as both an activator and a product of NF-κB activation ( Lopetuso et al, 2013 ; Cotino-Nájera et al, 2023 ). Hence, TNF-α and NF-κB are often studied together.…”

Section: Discussionmentioning

confidence: 99%

Study on the effect and mechanism of Lacticaseibacillus rhamnosus AFY06 on inflammation-associated colorectal cancer induced by AOM/DSS in mice

Zhang,

et al. 2024

Front. Microbiol.

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IntroductionLacticaseibacillus rhamnosus AFY06 (LR-AFY06) is a microorganism isolated from naturally fermented yogurt in Xinjiang, China.MethodsIn this study, we investigated the effects and mechanisms of LR-AFY06 in a mouse model of inflammation-associated colon cancer. The mouse model was established by azoxymethane/dextran sulfate sodium (AOM/DSS) induction. The tumor number in intestinal tissues was counted, and the histopathological analysis was performed on colon tissues. Enzyme-linked immunosorbent assay and real-time quantitative polymerase chain reaction were performed to measure relevant protein levels in colon tissues.ResultsLR-AFY06 treatment alleviated weight loss, increased organ index, reduced intestinal tumor incidence, improved histopathological damage, decreased the levels of inflammatory cytokines such as interleukin-6 (IL-6), interleukin-1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), nuclear factor κB (NF-κB), and inducible nitric oxide synthase (iNOS) in the serum and colon tissue, downregulated the mRNA expression of inhibitor of NF-κB beta (IκBβ), p65, p50, p52, B-cell lymphoma-2 (Bcl-2), and B-cell lymphoma-extra large (Bcl-xL) in colon tissues, and increased the mRNA expression of Bid and caspase-8. The high concentration of LR-AFY06 exerted a better effect than the low concentration; however, the effect was slightly inferior to that of aspirin. Moreover, LR-AFY06 mitigated the intestinal inflammatory process and inhibited intestinal tumor development by regulating the NF-κB and apoptosis pathways.DiscussionThe present study indicates the regulatory potential of LR-AFY06 in inflammation-associated colorectal cancer in mice, providing a valuable basis for further research.

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Section: Discussionmentioning

confidence: 99%

Study on the effect and mechanism of Lacticaseibacillus rhamnosus AFY06 on inflammation-associated colorectal cancer induced by AOM/DSS in mice

Zhang,

et al. 2024

Front. Microbiol.

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“…[ 211 ] Additionally, RES serves as a sensitizer to address the challenging issue of chemotherapy resistance. [ 212 , 213 ] For instance, RES enhances the sensitivity of GBM to temozolomide by downregulating STAT3 and O6‐methylguanine‐DNA methyltransferase (MGMT) levels associated with alkylating agent resistance, effectively attenuating tumor growth. [ 214 ] RES can also increase the chemosensitivity of GBM cells to doxorubicin by inhibiting the PI3K/AKT and P‐glycoprotein pathways.…”

Section: Tcm For Cns Diseasesmentioning

confidence: 99%

Progress in the Treatment of Central Nervous System Diseases Based on Nanosized Traditional Chinese Medicine

Li,

Long,

Ding

et al. 2024

Advanced Science

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Traditional Chinese Medicine (TCM) is widely used in clinical practice to treat diseases related to central nervous system (CNS) damage. However, the blood‐brain barrier (BBB) constitutes a significant impediment to the effective delivery of TCM, thus substantially diminishing its efficacy. Advances in nanotechnology and its applications in TCM (also known as nano‐TCM) can deliver active ingredients or components of TCM across the BBB to the targeted brain region. This review provides an overview of the physiological and pathological mechanisms of the BBB and systematically classifies the common TCM used to treat CNS diseases and types of nanocarriers that effectively deliver TCM to the brain. Additionally, drug delivery strategies for nano‐TCMs that utilize in vivo physiological properties or in vitro devices to bypass or cross the BBB are discussed. This review further focuses on the application of nano‐TCMs in the treatment of various CNS diseases. Finally, this article anticipates a design strategy for nano‐TCMs with higher delivery efficiency and probes their application potential in treating a wider range of CNS diseases.

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Serving up health: How phytochemicals transform food into medicine in the battle against cancer

Sharma,

Tewari,

Sati

et al. 2024

Food Frontiers

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The escalating global cancer burden underscores the urgent need for more effective therapeutic strategies. Phytochemicals, naturally occurring compounds in plants, have garnered attention for their potential in cancer chemoprevention and chemotherapy. Their ability to modulate molecular mechanisms and influence cell signaling pathways offers a promising avenue for cancer management. This review aims to synthesize current knowledge on phytochemicals’ chemopreventive and chemotherapeutic potential, focusing on their molecular mechanisms of action and impacts on cell signaling pathways involved in cancer. A systematic literature search was conducted across major databases, including PubMed/Medline, Web of Science, Scopus, and Google Scholar. The search strategy uses Medical Subject Headings (MeSH) and free‐text terms using Boolean operators to capture relevant studies. Inclusion criteria targeted original research and reviews on the effects of phytochemicals in cancer, with a specific focus on molecular mechanisms. Phytochemicals, including flavonoids, polyphenols, and terpenoids, demonstrated significant anticancer properties by inducing cell cycle arrest, apoptosis, and autophagy. They modulate critical cell signaling pathways, such as cyclooxygenase‐2, nuclear factor kappa B, and various growth factor‐related pathways, and rectify epigenetic alterations, contributing to their chemopreventive and therapeutic effects. Phytochemicals represent a valuable resource for developing novel cancer prevention and treatment strategies; their actions on molecular mechanisms and cell signaling pathways underscore their potential in cancer prevention and combat. Further research is warranted to translate these findings into clinical applications, optimizing phytochemical‐based interventions for cancer management.

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Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer

Cited by 5 publications

References 316 publications

Study on the effect and mechanism of Lacticaseibacillus rhamnosus AFY06 on inflammation-associated colorectal cancer induced by AOM/DSS in mice

Study on the effect and mechanism of Lacticaseibacillus rhamnosus AFY06 on inflammation-associated colorectal cancer induced by AOM/DSS in mice

Progress in the Treatment of Central Nervous System Diseases Based on Nanosized Traditional Chinese Medicine

Serving up health: How phytochemicals transform food into medicine in the battle against cancer

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