Molecular mechanisms of preeclampsia

Mutter, Walter P.; Karumanchi, S. Ananth

doi:10.1016/j.mvr.2007.04.009

Cited by 261 publications

(213 citation statements)

References 137 publications

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“…In addition, associated features of hyperuricemia and edema are often coexistent in renal transplant patients (62). It is interesting that histologic and molecular information show that preeclampsia is a disorder of placental hypoxia and endothelial dysfunction, although many mechanisms are yet unknown (60,63). Whether markers of preeclampsia such as angiogenic or antiangiogenc proteins will provide specific markers for preeclampsia is unknown but could provide a very important area for future study.…”

Section: Risks Of Pregnancy To the Mothermentioning

confidence: 99%

Pregnancy after Kidney Transplantation

McKay

Josephson²

2008

Clinical Journal of the American Society of Nephrology

127

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Reproductive success is a common, expected outcome for male and female recipients of solid-organ transplants. Men can father children, and women can become pregnant and carry the fetus to delivery. There are, however, important maternal and fetal complications that need to be considered to provide optimal care to the mother and her infant. Although pregnancy is common after the transplantation of all solid organs, guidelines for optimal counseling and clinical management are limited. This review discusses information to help the physician counsel the kidney transplant recipient about risks of pregnancy for the mother and the fetus and provides information to help guide treatment of the pregnant transplant recipient.

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Section: Risks Of Pregnancy To the Mothermentioning

confidence: 99%

Pregnancy after Kidney Transplantation

McKay

Josephson²

2008

Clinical Journal of the American Society of Nephrology

127

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“…Preeclampsia and other hypertensive disorders of preganancy such as chronic hypertension and gestational hypertension remain leading causes of maternal and perinatal morbidity and mortality. It has been estimated that preeclampsia occurs in 5-8 % of all pregnancies worldwide resulting in a very large health burden [1][2][3]. According to the guideline of National Institutes of Health publication No.…”

Section: Introductionmentioning

confidence: 99%

Novel Angiogenic Factors for Predicting Preeclampsia: sFlt-1, PlGF, and Soluble Endoglin~!2008-08-29~!2008-12-15~!2009-01-02~!

Chen¹

2009

TOCCHEMJ

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Preeclampsia is a devastating multisystem syndrome and is a major cause of maternal, fetal and neonatal morbidity and mortality. Angiogenic factors contribute to the molecular mechanisms of preeclampsia and its main phenotypes such as hypertension and proteinuria. Very recently, novel anti-angiogenic proteins including soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng), and one pro-angiogenic protein placental growth factor (PlGF) have been found to be significantly abnormal several weeks preceding the onset of clinical signs and symptoms. Automatic immunoassays are being developed for sFlt-1 and PlGF. This article will summarize our current knowledge of these markers and their roles on predicting preeclampsia.

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confidence: 99%

“…20 -22 Two important antiangiogenic factors produced in the placenta gain access to the maternal circulation and are involved in the pathogenesis of preeclampsia. [23][24][25] First, soluble fms-like tyrosine kinase-1 (sFLT-1) is a splice variant of the vascular endothelial growth factor receptor that captures vascular endothelial growth factor, 26,27 thus preventing its interaction with ligands and downregulating the biological effects of vascular endothelial growth factor, such as angiogenesis 28 and stimulation of NO synthesis by endothelial cells. 29 -31 Second, although soluble endogline (sEng) is found in healthy pregnancies, its concentrations increase in preeclampsia.…”

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confidence: 99%

Nitric Oxide Formation Is Inversely Related to Serum Levels of Antiangiogenic Factors Soluble Fms-Like Tyrosine Kinase-1 and Soluble Endogline in Preeclampsia

et al. 2008

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Abstract-Deficient NO formation has been implicated in hypertensive disorders of pregnancy. However, no previous study has compared the circulating nitrite concentrations in healthy pregnant women with those found in hypertensive disorders of pregnancy. Moreover, 2 antiangiogenic factors produced in the placenta (soluble fms-like tyrosine kinase-1 and soluble endogline) may affect NO formation during pregnancy. Here, we hypothesized that lower concentrations of markers of NO formation exist in hypertensive disorders of pregnancy and that inverse relationships exist between these markers and soluble fms-like tyrosine kinase-1 or soluble endogline. In this cross-sectional study, we compared 58 healthy pregnant women with 56 gestational hypertensive subjects and 45 preeclamptic patients. We measured plasma and whole blood nitrite concentrations using an ozone-based chemiluminescence assay and serum soluble fms-like tyrosine kinase-1 and soluble endogline concentrations using enzyme immunoassays. Whole blood nitrite levels were significantly lower in gestational hypertensive subjects and preeclamptic patients (Ϫ36% and Ϫ58%, respectively; both PϽ0.05) compared with healthy pregnant women. The plasma nitrite levels were Ϸ37% lower in both groups with hypertensive disorders of pregnancy compared with the group with normotensive pregnancies (both PϽ0.05). As expected, we found higher circulating soluble fms-like tyrosine kinase-1 and soluble endogline concentrations in preeclampsia compared with gestational hypertensive subjects or with healthy pregnancies (both PϽ0.05). Key Words: NO Ⅲ nitrite Ⅲ whole blood nitrite Ⅲ preeclampsia Ⅲ sEng Ⅲ sFLT-1 N ormal human pregnancy is accompanied by increased blood volume that is accommodated within the cardiovascular system by systemic vasodilatation. 1 This vasodilatation involves increased NO formation, thus decreasing peripheral vascular resistance in healthy pregnant women. 2,3 On the other hand, deficient NO formation has been implicated in hypertensive disorders of pregnancy, such as preeclampsia and gestational hypertension. 4 -7 Indeed, previous studies compared the circulating concentrations of NO metabolites (nitriteϩnitrate) in the plasma from preeclamptic women with those found in healthy pregnant women. 8 -13 Conflicting results were reported, and some studies showed higher, 14 similar, 10,12 or lower 8 nitriteϩnitrate levels in preeclamptic women compared with healthy pregnant women. A possible explanation for these discrepancies is that nitriteϩnitrate may not accurately reflect endogenous NO formation in vivo, and there is mounting evidence that measuring the circulating concentrations of nitrite is an improved alternative to assess endogenously produced NO. [15][16][17][18][19] However, no previous study has compared the circulating nitrite concentrations in healthy pregnant women with those found in women with preeclampsia.The pathophysiology of preeclampsia is not completely known. However, there is evidence that a failure of cytotrophoblast invasion and abse...

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Molecular mechanisms of preeclampsia

Cited by 261 publications

References 137 publications

Pregnancy after Kidney Transplantation

Pregnancy after Kidney Transplantation

Novel Angiogenic Factors for Predicting Preeclampsia: sFlt-1, PlGF, and Soluble Endoglin~!2008-08-29~!2008-12-15~!2009-01-02~!

Nitric Oxide Formation Is Inversely Related to Serum Levels of Antiangiogenic Factors Soluble Fms-Like Tyrosine Kinase-1 and Soluble Endogline in Preeclampsia

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