Molecular Mechanisms of Possible Action of Phenolic Compounds in COVID-19 Protection and Prevention

Gligorijević, Nevenka; Radomirović, Mirjana; Nedić, Olgica; Stojadinovic, Marija; Urmila, K. S.; Stanić-Vučinić, Dragana; Veličković, Tanja Ćirković

doi:10.3390/ijms222212385

Cited by 20 publications

(15 citation statements)

References 169 publications

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“…During the writing of the manuscript, the snowballing technique was used to include other studies relevant to the topic (from any period) from the references of the selected articles. Since the targets of SARS-CoV 1 and 2 are very similar, results on activity against SARS-CoV were also shown, as suggested by Gligorijevic et al (2021) . To complement the anti-COVID-19 potential of PCs, a brief explanation was made on their immunomodulatory/anti-inflammatory/antioxidant effect, which strengthens the body's defenses to prevent COVID-19 or resist its impact in case of infection.…”

Section: Methodsmentioning

confidence: 70%

Section: Methodsmentioning

confidence: 70%

“…Fortunately, many isolated PCs such as baicalein, hesperidin, quercetin, luteolin, gallocatechin, epigallocatechin gallate, kaempferol, and isoliquiritigenin have shown efficiency in its inhibition ( Paraiso et al, 2020 ; de la Lastra et al, 2021 ). For example, xanthoangelol E from Angelica keiskei , PCs from Psoralea corylifolia seeds and PCs from Broussonetia papyrifera showed an IC50 value of de 1,2, 15 g/L y 3,7 μM, respectively against SARS-CoV PLpro ( Gligorijevic et al, 2021 ). When evaluating the potential of myricetin from Scutellaria baicalensis against nsP13 helicase of SARS-CoV, the IC50 value was 2.71 μM.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Phenolic compounds versus SARS-CoV-2: An update on the main findings against COVID-19

Tirado-Kulieva¹,

Hernández-Martínez

Rivera³

2022

Heliyon

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Section: Methodsmentioning

confidence: 70%

Section: Methodsmentioning

confidence: 70%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Phenolic compounds versus SARS-CoV-2: An update on the main findings against COVID-19

Tirado-Kulieva¹,

Hernández-Martínez

Rivera³

2022

Heliyon

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“…Generally, water extract exhibited varied types of active metabolites with two phenolics, coumari and flavonoid which could have synergetic activity against SARS-CoV-2. The increased activity of water extract could be attributed to a high concentration of polar molecules, particularly phenolic compounds with high antioxidant and antiviral properties [ 42 ]. Again, the presence of coumarin and flavonoids contributed to antiviral activity which havebeen reported by other studies to have high antiviral activity against SARS-CoV-2 [ 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

Screening and evaluation of cytotoxicity and antiviral effects of secondary metabolites from water extracts of Bersama abyssinica against SARS-CoV-2 Delta

Zekeya

Mamiro

Ndossi

et al. 2022

BMC Complement Med Ther

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Background Bersama abyssinica is a common herb in Africa, with diverse medical uses in different areas. The plant is well-known in Tanzania for treating respiratory disorders such as TB, tonsillitis, bronchitis, and asthma, and it has lately been utilized to treat COVID-19 symptoms. Water extract of leaf and stem bark has been registered as an herbal medication known as 'Coviba Dawa' in Tanzania for the relief of bacterial respiratory infections. The extracts, however, have not been scientifically tested for their anti-viral activities. The aim of this work was to test for the cytotoxicity and antiviral effects of bioactive ingredients from B. abyssinica extracts against the Delta variant of the SARS-CoV-2 coronavirus. Methods B. abyssinica leaves and stem bark were dried under shade in room temperature and then pulverized to obtain small pieces before soaking into different solvents. One hundred grams of each, leaves and stem bark, were extracted in petroleum ether, dichloromethane, ethyl acetate and methanol. Water extract was obtained by decoction of stem bark and leaves into water. Phenols, flavonoids, tannins, and antioxidants were confirmed as components of the extracts. Analysis of polar extracts of bark stem bark and leaves was done. Antiviral screening and cytotoxicity experiments were conducted in a Biosafety Level 3 (BSL-3) Laboratory facility according to International Standard Operating Procedures (SOPs). Results By the use of LC–MS/MS analysis, this study confirmed the existence of four phenolic compounds in B. abyssinica water extract; 2,4-di-tert-butylphenol, 4-formyl-2-methoxyphenyl propionate, 7,8-Dihydroxy-4-methylcoumarin, and 2,3, 6-trimethoxyflavone with antioxidant activity. This study showed that, while the water extracts of B. abyssinica had significant antiviral activity against SARS Cov2 virus, it showed no cytotoxicity effect on Vero E6 cells. In particular, the water extract (Coviba dawa) showed 75% while ethylacetate fraction of B. abyssinica leaves showed a 50% in vitro viral inhibition, indicating that these substances may be useful for the development of future anti-viral agents. Conclusion We therefore recommend isolation of compounds for further profiling and development with a broader concentration range. We further recommend studies that determine the antiviral activity of extracts of B.abyssinica on other viral pathogens of clinical concern.

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“…Multiple examples of compound screens in various cell-based or virtual assays have been published since last year. A mention of one compound class, polyphenolic plant compounds, merits note since multiple members of this class have been or are under clinical evaluation as treatments for COVID-19 disease 16 .…”

Section: Introductionmentioning

confidence: 99%

Tucaresol: A Unique Oral Candidate Drug Ideally Accessible for Treatment of COVID-19 Disease

Penney¹,

Zacharie²,

Duceppe³

2022

Preprint

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The SARS-CoV-2 pandemic has significantly impacted world health and economic status. In response, much work has been undertaken to provide effective, safe vaccines, antibodies and antiviral drugs with which to address this pandemic. Treatment of a pandemic population presents multiple challenges in addition to the primary issue of drug efficacy and safety, such as large scale drug manufacture and distribution, drug stability, oral dosing and pharmacoeconomic considerations. Ideally, these factors must be addressed if new candidate drugs are to be advanced for treatment of large (pandemic) populations. Subsequently, new antivirals have reached the market but choices are few. According to the NIH Covid Treatment Guidelines, only three small molecule antiviral drugs are available to treat COVID-19 disease. As such, a significant part of the research towards discovery of new antiviral drugs has focused on screening and evaluation of ‘repurposed drugs’ or previously approved or clinical stage drugs. Yet, in spite of this increased research activity, one promising clinical stage candidate drug has received little attention regarding its potential as a monotherapy or component of combination therapy for treatment of COVID-19 disease. Tucaresol, with documented human safety and pharmacokinetic data, is an orally active, stable, small molecule amenable to large scale manufacture by a proprietary two-step synthesis developed by us. Tucaresol functions as a host-targeted antiviral by selective protection/reconstitution of CD4+ T helper cells as demonstrated in HIV patients and SIV macaques. In view of similarities between HIV and SARS-CoV-2, especially with respect to host CD4+ T helper cells, and the suitability of Tucaresol for facile treatment of pandemic populations, Tucaresol is presented herein for treatment of mild-to-moderate COVID-19 patients but may also be useful for treatment of advanced disease accompanied by lymphopenia.

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Molecular Mechanisms of Possible Action of Phenolic Compounds in COVID-19 Protection and Prevention

Cited by 20 publications

References 169 publications

Phenolic compounds versus SARS-CoV-2: An update on the main findings against COVID-19

Phenolic compounds versus SARS-CoV-2: An update on the main findings against COVID-19

Screening and evaluation of cytotoxicity and antiviral effects of secondary metabolites from water extracts of Bersama abyssinica against SARS-CoV-2 Delta

Tucaresol: A Unique Oral Candidate Drug Ideally Accessible for Treatment of COVID-19 Disease

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