Molecular mechanisms of oxidative stress in stroke and cancer

Chavda, Vishal; Lu, Prof. Dr. Bingwei; Chaurasia, Bipin; Garg, Kanwaljeet; Deora, Harsh; UMANA, GIUSEPPE E.; Palmisciano, Paolo; Scalia, Gianluca

doi:10.1016/j.dscb.2021.100029

Cited by 38 publications

(37 citation statements)

References 149 publications

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“…Metastasis is a multistep process that comprises cell migration from the primary tumor site, cell invasion, attachment to endothelial cells, extravasation, proliferation, and angiogenesis at the distal site [ 53 , 56 ]. Degradation of the extracellular matrix, especially collagen, mediated by proteolytic enzymes such as MMP-2 (gelatinase-A) and MMP-9 (gelatinase-B), is known to be the first step and plays a crucial role during cell migration and invasion [ 31 , 57 ].…”

Section: Discussionmentioning

confidence: 99%

Influence of Plasma-Isolated Anthocyanins and Their Metabolites on Cancer Cell Migration (HT-29 and Caco-2) In Vitro: Results of the ATTACH Study

et al. 2022

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Cancer mortality is mainly due to metastasis. Therefore, searching for new therapeutic agents suppressing cancer cell migration is crucial. Data from human studies regarding effects of anthocyanins on cancer progression, however, are scarce and it is unclear whether physiological concentrations of anthocyanins and their metabolites reduce cancer cell migration in vivo. In addition, interactions with chemotherapeutics like 5-fluorouracil (5-FU) are largely unknown. Thus, we combined a placebo-controlled, double-blinded, cross-over study with in vitro migration studies of colon cancer cell lines to examine the anti-migratory effects of plasma-isolated anthocyanins and their metabolites (PAM). Healthy volunteers (n = 35) daily consumed 0.33 L of an anthocyanin-rich grape/bilberry juice and an anthocyanin-depleted placebo juice for 28 days. PAM were isolated before and after intervention by solid-phase extraction. HT-29 and Caco-2 cells were incubated with PAM in a Boyden chamber. Migration of HT-29 cells was significantly inhibited by PAM from juice but not from placebo. In contrast, Caco-2 migration was not affected. Co-incubation with 5-FU and pooled PAM from volunteers (n = 10), which most effectively inhibited HT-29 migration, further reduced HT-29 migration in comparison to 5-FU alone. Therefore, PAM at physiological concentrations impairs colon cancer cell migration and may support the effectiveness of chemotherapeutics.

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Section: Discussionmentioning

confidence: 99%

Influence of Plasma-Isolated Anthocyanins and Their Metabolites on Cancer Cell Migration (HT-29 and Caco-2) In Vitro: Results of the ATTACH Study

et al. 2022

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“…Exposure to DENA is associated with hepatocellular accumulation of ROS [ 58 ], which in turn could trigger apoptosis in the liver [ 59 , 60 ]. Chavda et al [ 61 ] published literature evidence in their review work that the oxidative stress can cause cell apoptosis only at high concentrations. Thus, ROS levels play a critical role in either promoting tumorigenesis or causing apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Pomegranate juice and punicalagin-mediated chemoprevention of hepatocellular carcinogenesis via regulating miR-21 and NF-κB-p65 in a rat model

et al. 2022

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Background Hepatocellular carcinoma (HCC) is the most common neoplasm among primary liver malignancies, accounting for 70%–85% of total liver cancer cases worldwide. It is also the second-leading cause of cancer-related death worldwide. Recent research has investigated naturally occurring products high in polyphenolic compounds in the regression and prevention of HCC. This study investigated the chemoprevention effects of pomegranate juice (PJ) and punicalagin (PCG) against diethylnitrosamine (DENA)-induced hepatocarcinogenesis in male albino rats. Methods Animals were randomized into six groups and treated for 11 weeks as follows: group 1 was a negative control group, group 2 was treated orally with 10 mL PJ per kilogram body weight (kg bw), group 3 was treated orally with 18.5 mg PCG/kg bw, and groups 4–6 were injected with an intraperitoneal dose of DENA (50 mg/kg bw) weekly beginning in the third week. Group 4 was a HCC control (DENA-treated group), group 5 was HCC + PJ, and group 6 was HCC + PCG. Results PJ antagonized DENA-induced elevations of ALAT, TNF-α, NF-κB-p65, GST, MDA, and NO and restored total protein, IL-10, SOD, and CAT levels. Moreover, PJ resulted in downregulation of miR-21, Bcl-2, and Bcl-XL and an upregulation of caspase-3 and Bax mRNA expressions. These chemoprevention effects of PJ also alleviated the hepatic preneoplastic lesions induced by DENA. Although PCG treatment induced some modulation in DENA-treated rats, it did not show potent chemoprevention activity and induced some side effects. Conclusion Both of PJ and PCG downregulated miR-21 expression and triggered apoptosis. However, PJ was more effective than pure PCG in alleviating the hepatic antioxidant defense state and the inflammatory status. So, PJ was superior in prevention of DENA-induced hepatocellular carcinogenesis in rats than pure PCG. Graphical Abstract

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“…Voglibose, saxagliptin, and dapagliflozin all appear to have anti-oxidant characteristics through raising nitrite levels. As a consequence of mitochondrion respiration, Increased Reverse Electron Transport (RET) SOD levels and activity are key contributors to oxidative stress and can be exceedingly harmful to proper cell-cell function ( Clausen et al, 2010 ) ( Chavda et al, 2022 ). In our research, we observed significant decrease in SOD activity in diabetic MCAo group which had been subjected to persistent anaesthesia, that was greatly alleviated by dapagliflozin, repaglinide, and saxagliptin.…”

Section: Discussionmentioning

confidence: 99%

Voglibose and saxagliptin ameliorate the post-surgical stress and cognitive dysfunction in chronic anaesthesia exposed diabetic MCAo induced ischemic rats

Molecular mechanisms of oxidative stress in stroke and cancer

Cited by 38 publications

References 149 publications

Influence of Plasma-Isolated Anthocyanins and Their Metabolites on Cancer Cell Migration (HT-29 and Caco-2) In Vitro: Results of the ATTACH Study

Influence of Plasma-Isolated Anthocyanins and Their Metabolites on Cancer Cell Migration (HT-29 and Caco-2) In Vitro: Results of the ATTACH Study

Pomegranate juice and punicalagin-mediated chemoprevention of hepatocellular carcinogenesis via regulating miR-21 and NF-κB-p65 in a rat model

Voglibose and saxagliptin ameliorate the post-surgical stress and cognitive dysfunction in chronic anaesthesia exposed diabetic MCAo induced ischemic rats

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