Molecular mechanisms of oxidative stress in asthma

Michaeloudes, Charalambos; Abubakar-Waziri, Hisham; Lakhdar, Ramzi; Raby, Katie; Dixey, Piers; Adcock, Ian M.; Mumby, Sharon; Bhavsar, Pankaj; Chung, Kian Fan

doi:10.1016/j.mam.2021.101026

Cited by 127 publications

(118 citation statements)

References 267 publications

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“…Untargeted metabolomic profiling has been performed using MS on plasma, urine, stool, and exhaled breath samples from children with asthma [118][119][120][121][122]. In a study using untargeted LC-MS analysis of plasma metabolomes, children with severe asthma were distinguished by metabolic pathways associated with oxidative stress [121], in agreement with observations of increased oxidative stress in asthma exacerbations [123]. An association between plasma levels of ceramides and sphingomyelins at the age of 6 months and an increased risk of subsequent asthma development was found to be modified by 17q21 genotype [119].…”

Section: Metabolomics Of Asthmasupporting

confidence: 57%

Multi-Omics Profiling Approach to Asthma: An Evolving Paradigm

Gautam

Johansson

Mersha

2022

JPM

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Asthma is a complex multifactorial and heterogeneous respiratory disease. Although genetics is a strong risk factor of asthma, external and internal exposures and their interactions with genetic factors also play important roles in the pathophysiology of asthma. Over the past decades, the application of high-throughput omics approaches has emerged and been applied to the field of asthma research for screening biomarkers such as genes, transcript, proteins, and metabolites in an unbiased fashion. Leveraging large-scale studies representative of diverse population-based omics data and integrating with clinical data has led to better profiling of asthma risk. Yet, to date, no omic-driven endotypes have been translated into clinical practice and management of asthma. In this article, we provide an overview of the current status of omics studies of asthma, namely, genomics, transcriptomics, epigenomics, proteomics, exposomics, and metabolomics. The current development of the multi-omics integrations of asthma is also briefly discussed. Biomarker discovery following multi-omics profiling could be challenging but useful for better disease phenotyping and endotyping that can translate into advances in asthma management and clinical care, ultimately leading to successful precision medicine approaches.

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Section: Metabolomics Of Asthmasupporting

confidence: 57%

Multi-Omics Profiling Approach to Asthma: An Evolving Paradigm

Gautam

Johansson

Mersha

2022

JPM

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“…These increased radicals drive the activation of various inflammatory and cell death pathways to initiate the detrimental events of the asthma like the epithelial cell damage and cell death, increased mucus production, increased release of danger-associated molecular patterns, eosinophils, and neutrophil infiltration into the airway lumen, and increased airway hyperresponsiveness and airway remodelling. The order of these reactive potentials of the free radicals and the oxidants are the superoxide anion (O 2 −• ) which is considered the major precursor that is mainly produced by the oxidative phosphorylation from the mitochondrial source or from the reduced nicotinamide adenine phosphate (NADPH) oxidation catalyzed by NADPH oxidases (Nox) (Michaeloudes et al 2022) followed by hydrogen peroxide (H 2 O 2 ), hydroxyl radical (HO • ), singlet oxygen (1O 2 ), peroxyl radical (HO 2…”

Section: Oxygen Radicals That Mediate Oxidative Stress In Asthmamentioning

confidence: 99%

Nutraceuticals and mitochondrial oxidative stress: bridging the gap in the management of bronchial asthma

Allam

Paudel

Gupta

et al. 2022

Environ Sci Pollut Res

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Asthma is a chronic inflammatory disease primarily characterized by inflammation and reversible bronchoconstriction. It is currently one of the leading causes of morbidity and mortality in the world. Oxidative stress further complicates the pathology of the disease. The current treatment strategies for asthma mainly involve the use of anti-inflammatory agents and bronchodilators. However, long-term usage of such medications is associated with severe adverse effects and complications. Hence, there is an urgent need to develop newer, novel, and safe treatment modalities for the management of asthma. This has therefore prompted further investigations and detailed research to identify and develop novel therapeutic interventions from potent untapped resources. This review focuses on the significance of oxidative stressors that are primarily derived from both mitochondrial and non-mitochondrial sources in initiating the clinical features of asthma. The review also discusses the biological scavenging system of the body and factors that may lead to its malfunction which could result in altered states. Furthermore, the review provides a detailed insight into the therapeutic role of nutraceuticals as an effective strategy to attenuate the deleterious effects of oxidative stress and may be used in the mitigation of the cardinal features of bronchial asthma.

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“…Whatever form and chemical species they acquire inside the body, nanomaterials can cause oxidative stress, important factor for the increase of the immunogenicity of allergens [79] for the induction of allergic reactions [80][81][82][83] and responsible for lung [84] and skin inflammation [54,85]. The increase in reactive oxygen species (ROS) can worsen already present allergic conditions [45].…”

Section: Nanoparticles Worsening Established Allergymentioning

confidence: 99%

Exposure to nanoparticles and occupational allergy

Gioacchino

Giampaolo

Mangifesta

et al. 2022

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewTo provide an update on the possible role of nanoparticles as sensitizing occupational agents and on the influence of nanoparticles-exposure on the appearance/exacerbation of occupational allergy. Recent findingsRecent case reports, epidemiological studies, and experimental investigations in cellular and animal models demonstrated the potential for nanomaterials to favor/interfere with occupational allergy. First data are emerging on the sensitizing potential of nanoparticles that can act as haptens linking to proteins, with a formation of a 'corona'. Nanoparticles with carrier protein become a complete antigen and induce specific immune response. Moreover, they act as adjuvant favoring sensitization to bound molecules. The disruption of the respiratory and skin barrier, the modulation of immune response toward Th1 or Th2 immune reaction and the interaction with immune effector cells (mast cells and eosinophil in particular) can explain the potential for nanoparticles to exacerbate pre-existing allergic conditions.

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Molecular mechanisms of oxidative stress in asthma

Cited by 127 publications

References 267 publications

Multi-Omics Profiling Approach to Asthma: An Evolving Paradigm

Multi-Omics Profiling Approach to Asthma: An Evolving Paradigm

Nutraceuticals and mitochondrial oxidative stress: bridging the gap in the management of bronchial asthma

Exposure to nanoparticles and occupational allergy

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