Molecular mechanisms of neuroprotection by two natural antioxidant polyphenols

Campos-Esparza, María Rosario; Sánchez‐Gómez, María Victoria; Matute, Carlos

doi:10.1016/j.ceca.2008.12.007

Cited by 163 publications

(115 citation statements)

References 54 publications

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“…Studies investigating the neuroprotective effects of morin have been inconclusive. For example, morin was found to be neuroprotective in a model of ischemic brain damage, and this effect was attributed to its antioxidant and antiapoptotic [14] . However, in another in vitro study, morin and other antioxidants failed to protect plastic adhering PC12 cells from MPP + toxicity.…”

Section: Introductionmentioning

confidence: 99%

Morin exerts neuroprotective actions in Parkinson disease models in vitro and in vivo

et al. 2010

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Aim: To investigate the neuroprotective effects of morin on 1-methyl-4-phenylpyridinium ion (MPP + )-induced apoptosis in neuronal differentiated PC12 cells as well as in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson disease (PD). Methods: PC12 cells were challenged with MPP + in the presence or absence of morin. Cell viability was determined using MTT assay. Cell apoptosis was measured using flow cytometry. Generation of reactive oxygen species (ROS) was assayed using fluorescence assay. In an MPTP mouse model of PD, behavioral deficits, striatal dopamine content, and number of dopaminergic neurons were measured. Results: MPP + induced apoptosis and ROS formation in PC12 cells. Concomitant treatment with morin (5-50 μmol/L) significantly attenuated the loss of cell viability and apoptosis when compared with MPP + treatment alone. Morin also attenuated ROS formation induced by MPP + . MPTP induced permanent behavioral deficits and nigrostriatal lesions in mice. When administered prior to MPTP, morin (20 to 100 mg/kg) attenuated behavioral deficits, dopaminergic neuronal death and striatal dopamine depletion in the MPTP mouse model. Conclusion: The findings suggest that morin has neuroprotective actions both in vitro and in vivo, and may provide a novel therapeutic agent for the treatment of PD and other neurodegenerative diseases.

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Section: Introductionmentioning

confidence: 99%

Morin exerts neuroprotective actions in Parkinson disease models in vitro and in vivo

et al. 2010

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“…Mangiferin shows exceptional antioxidant activity, stronger than cinnamon, and hepatoprotective activity against free radical-induced liver injury in the mouse in vivo [4]. It also dose-dependently inhibits inflammatory cytokines, tumor necrosis factor alpha (TNFα), nitric oxide (NO), and NF-κBin in vitro and in vivo experiments in the mouse [9], which suggests this is the mechanism of anti-inflammatory effects of M. indica extracts. Finally, mangiferin shows antiapoptoticaction that protects against glutaminergicexcitotoxicity leading to neuronal death [9,10].…”

Section: +mentioning

confidence: 88%

“…It also dose-dependently inhibits inflammatory cytokines, tumor necrosis factor alpha (TNFα), nitric oxide (NO), and NF-κBin in vitro and in vivo experiments in the mouse [9], which suggests this is the mechanism of anti-inflammatory effects of M. indica extracts. Finally, mangiferin shows antiapoptoticaction that protects against glutaminergicexcitotoxicity leading to neuronal death [9,10]. The central effects of mangiferin include the antagonism of sedation induced by reserpine [2], which may explain the time proven traditional use of mangiferin containing extracts as a mood enhancer.…”

Section: +mentioning

confidence: 99%

Mangiferin - A Nutraceutical with Clinical Implications

Pokorski¹

2014

Vitam Miner

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“…The members of the Bcl-2 family such as Bcl-2 and Bax proteins are the most prominent factors in the mitochondria-mediated apoptotic pathway [3,9]. Studies have shown the powerful properties of various natural polyphenols against neuronal exitotoxicity induced by NMDA [10,11]. Sesamin (a typical lignan with β-linkage) and sesamolin (a compound with a phenyl group with an acetaloxygen bridge) are two major lignans in sesame seeds and oil ( Figure 1A), which are also found in several medicinal herbs, such as Acanthopanax senticosus.…”

Section: Introductionmentioning

confidence: 99%