Molecular Mechanisms of miR-214 Involved in Cancer and Drug Resistance

Abstract

: As a transcriptional regulation element, the microRNA plays a crucial role in any aspect of molecular biological processes like cellular metabolism, cell division, cell death, cell movement, intracellular signaling, and immunity was discovered. Previous studies have been suggested that microRNA-214 (miR-214) probably is a valuable marker in cancer. Here, in this perspective, we provide a brief updated overview of the vital dual role of miR-214 in cancer as a tumor suppressor or oncogene. We also collected target genes and signaling pathways related to the dysregulation of miR-214 by previous experimental research in various human diseases. To highlight the critical function of miR-214 in the prognostic, diagnostic, and pathogenesis of cancer diseases, we focused on the probable clinical biomarker and drug resistance function of miR-214. The current research provides a comprehensive perspective of the regulatory mechanisms governed by miR-214 in human disease pathogenesis and a list of probable candidates for future study.