Molecular Mechanisms of Memory in Males and Females

Keiser, Ashley A.; Tronson, Natalie C.

doi:10.1016/b978-0-12-802114-9.00002-0

Cited by 12 publications

(10 citation statements)

References 150 publications

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“…Nevertheless, we observed that dorsal hippocampus was activated during consolidation of context fear conditioning in both males and females. This is consistent with findings that both males and females activate hippocampus during consolidation of context fear but recruit different molecular mechanisms in this region (Dachtler et al, 2011;Keiser and Tronson, 2016;Mizuno et al, 2007). It remains unclear how sex differences in mechanisms of memory consolidation contribute to subsequent retrieval and generalization of context fear.…”

Section: Discussionsupporting

confidence: 90%

Sex Differences in Context Fear Generalization and Recruitment of Hippocampus and Amygdala during Retrieval

Keiser

Turnbull

Darian

et al. 2016

Neuropsychopharmacol

179

163

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Anxiety disorders are commonly associated with increased generalization of fear from a stress- or trauma-associated environment to a neutral context or environment. Differences in context-associated memory in males and females may contribute to increased susceptibility to anxiety disorders in women. Here we examined sex differences in context fear generalization and its neural correlates. We observed stronger context fear conditioning and more generalization of fear to a similar context in females than males. In addition, context preexposure increased fear conditioning in males and decreased generalization in females. Accordingly, males showed stronger cFos activity in dorsal hippocampus during memory retrieval and context generalization, whereas females showed preferential recruitment of basal amygdala. Together, these findings are consistent with previous research showing that hippocampal activity correlates with reduced context fear generalization. Differential competition between hippocampus and amygdala-dependent processes may thus contribute to sex differences in retrieval of context fear and greater generalization of fear-associated memory.

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Section: Discussionsupporting

confidence: 90%

Sex Differences in Context Fear Generalization and Recruitment of Hippocampus and Amygdala during Retrieval

Keiser

Turnbull

Darian

et al. 2016

Neuropsychopharmacol

179

163

View full text Add to dashboard Cite

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“…Molecular mechanisms underlying memory formation include many specific signaling pathways involving neurotransmitter release, calcium influx, and second messenger activation, transcription of genes, de novo protein synthesis, and histone modification of gene expression (Keiser and Tronson, 2016 ). Each of these transduction pathways may be disrupted with methamphetamine (MA), a psychostimulant drug that primarily blocks dopaminergic and serotonergic systems (Sulzer et al, 2005 ).…”

Section: Introductionmentioning

confidence: 99%

The Impact of Neonatal Methamphetamine on Spatial Learning and Memory in Adult Female Rats

Petrikova-Hrebickova

Ševčíková

Šlamberová

2021

Front. Behav. Neurosci.

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The present study was aimed at evaluating cognitive changes following neonatal methamphetamine exposure in combination with repeated treatment in adulthood of female Wistar rats. Pregnant dams and their pups were used in this study. One half of the offspring were treated indirectly via the breast milk of injected mothers, and the other half of pups were treated directly by methamphetamine injection. In the group with indirect exposure, mothers received methamphetamine (5 mg/ml/kg) or saline (1 ml/kg) between postnatal days (PD) 1–11. In the group with direct exposure, none of the mothers were treated. Instead, progeny were either: (1) treated with injected methamphetamine (5 mg/ml/kg); or (2) served as controls and received sham injections (no saline, just a needle stick) on PD 1–11. Learning ability and memory consolidation were tested on PD 70–90 in the Morris Water Maze (MWM) using three tests: Place Navigation Test, Probe Test, and Memory Recall Test. Adult female progeny were injected daily, after completion of the last trial of MWM tests, with saline or methamphetamine (1 mg/ml/kg). The effects of indirect/direct neonatal methamphetamine exposure combined with acute adult methamphetamine treatment on cognitive functions in female rats were compared. Statistical analyses showed that neonatal drug exposure worsened spatial learning and the ability to remember the position of a hidden platform. The study also demonstrated that direct methamphetamine exposure has a more significant impact on learning and memory than indirect exposure. The acute dose of the drug did not produce any changes in cognitive ability. Analyses of search strategies (thigmotaxis, scanning) used by females during the Place Navigation Test and Memory Recall Test confirmed all these results. Results from the present study suggested extensive deficits in learning skills and memory of female rats that may be linked to the negative impact of neonatal methamphetamine exposure.

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“…Nevertheless, sex differences have been observed across a broad range of memory tasks including verbal memory (Kramer et al, 1988), context fear conditioning (Maren et al, 1994; Keiser et al, in review ), extinction of fear conditioning (Lebron-Milad et al, 2012), reward-related learning (Quinn et al, 2007), and spatial memory (Voyer et al, 2016), among others (see also Andreano and Cahill, 2009; Galea et al, 2013). Sex differences are also evident across the cognitive strategies used to learn a task (Grissom et al, 2013; Shah et al, 2013), neural circuits recruited for memory (Gruene et al, 2014), the molecular mechanisms of memory (Keiser and Tronson, 2016), and the modulation of memory by stress (Waddell et al, 2008). Many disorders of memory, including Alzheimer’s disease (Seshadri et al, 1997) and post-traumatic stress disorder (Kessler et al, 2012), are more prevalent in women than in men (Sohrabji et al, 2016).…”

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confidence: 99%

(Putative) sex differences in neuroimmune modulation of memory

Tronson

Collette

2016

J of Neuroscience Research

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The neuroimmune system is significantly sexually dimorphic, with sex differences evident in the number and activation states of microglia, in the activation of astrocytes, and in cytokine release and function. Neuroimmune cells and signaling are now recognized as critical for many neural functions throughout the lifespan, including synaptic plasticity and memory function. Here we address the question of how cytokines, astrocytes, and microglia contribute to memory, and specifically how neuroimmune modulation of memory differentially affects males and females. Understanding sex differences in both normal memory processes and dysregulation of memory in psychiatric and neurological disorders is critical for developing treatment and preventive strategies for memory disorders that are effective for both men and women.

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Molecular Mechanisms of Memory in Males and Females

Cited by 12 publications

References 150 publications

Sex Differences in Context Fear Generalization and Recruitment of Hippocampus and Amygdala during Retrieval

Sex Differences in Context Fear Generalization and Recruitment of Hippocampus and Amygdala during Retrieval

The Impact of Neonatal Methamphetamine on Spatial Learning and Memory in Adult Female Rats

(Putative) sex differences in neuroimmune modulation of memory

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