Molecular mechanisms of mammalian inorganic phosphate homeostasis

Takeda, Eiji; Taketani, Yutaka; Morita, Kyoko; Tatsumi, Sawako; Katai, Kanako; Nii, Tomoko; Yamamoto, Hironori; Miyamoto, Ken‐ichi

doi:10.1016/s0065-2571(99)00036-9

Cited by 41 publications

(42 citation statements)

References 42 publications

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“…The kidney is a major regulator of Pi homeostasis and can increase or decrease its Pi-reabsorptive capacity to accommodate Pi need. The bulk of filtered Pi is reabsorbed in the proximal tubule, where sodium-dependent Pi transport system in the brush-border membrane mediates the rate-limiting step in the overall Pi-reabsorptive process (12). As mentioned earlier, Pi plays a key role in diverse physiologic functions.…”

Section: Discussionmentioning

confidence: 98%

Elevated Inorganic Phosphate Stimulates Akt-ERK1/2-Mnk1 Signaling in Human Lung Cells

Chang

Lee

et al. 2006

Am J Respir Cell Mol Biol

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Inorganic phosphate (Pi) is present in bacteria, fungus, plant, and animal cells. Pi plays a critical role in mineral metabolism, and diverse cellular functions involving intermediary metabolism and energy transfer. It is a vital component of membrane phospholipids, nucleotides that provide energy, DNA and RNA, and is necessary for phosphorylated intermediates in cellular signaling (1).Bronchial epithelial cells, the progenitor cells for bronchogenic carcinomas, are often exposed to diverse xenobiotics, including toxicants. Many investigators elucidated the precise mechanisms of pulmonary toxicant-induced normal bronchial epithelial cell damage. The response of bronchial epithelium to chemical and physical injury has been associated with the induction of hyperplasia and the subsequent development of squamous metaplasia (2). The modified response of nontumorigenic bronchial epithelial cells to external/internal stimuli causes a disturbance in the homeostasis between normal cell survival and growth. Therefore, the elucidation of such disturbed homeo-

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Section: Discussionmentioning

confidence: 98%

Elevated Inorganic Phosphate Stimulates Akt-ERK1/2-Mnk1 Signaling in Human Lung Cells

Chang

Lee

et al. 2006

Am J Respir Cell Mol Biol

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“…To meet the additional physiological demands, which include the maintenance of total body phosphate homeostasis and the coordination of the kidneys and intestines. Particularly, the phosphate concentration and homeostasis primarily depend on tubular phosphate transport in the kidneys, at the membrane of the renal tubular brush border (Takeda et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Biological effects of inorganic phosphate: potential signal of toxicity

et al. 2015

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-Inorganic phosphate (Pi) plays crucial roles in several biological processes and signaling pathways. Pi uptake is regulated by sodium-dependent phosphate (Na/Pi) transporters (NPTs). Moreover, Pi is used as a food additive in food items such as sausages, crackers, dairy products, and beverages. However, the high serum concentration of phosphate (> 5.5 mg/dL) can cause adverse renal effects, cardiovascular effects including vascular or valvular calcification, and stimulate bone resorption. In addition, Pi can also alter vital cellular signaling, related to cell growth and cap-dependent protein translation. Moreover, intake of dietary Pi, whether high (1.0%) or low (0.1%), affects organs in developing mice, and is related to tumorigenesis in mice. The recommended dietary allowance (RDA) of Pi is the daily dietary intake required to maintain levels above the lower limit of the range of normal serum Pi concentration (2.7 mg/dL) for most individuals (97-98%). Thus, adequate intake of Pi (RDA; 700 mg/day) and maintenance of normal Pi concentration (2.7-4.5 mg/dL) are important for health and prevention of diseases caused by inadequate Pi intake.

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“…Although more than 80% of total body phosphorus is stored in bone and teeth, intracellular phosphorus exists in the form of organic compounds such as adenosine triphosphate and as free anions like H 2 PO 4 -, which are commonly referred to as phosphate. Serum phosphorus primarily occurs in the form of inorganic phosphate, which is maintained within the physiological range by regulation of dietary absorption, bone formation, and renal excretion, as well as equilibration with intracellular stores (Takeda et al, 2000;Bringhurst et al, 2004;Fukagawa et al, 2004;Blumsohn, 2004). Phosphate absorption in the renal proximal tubule and the small intestine is important for phosphate homeostasis.…”

Section: Phosphate Metabolism In Normal Physiologymentioning

confidence: 99%

“…This is a major regulator of phosphate homeostasis and has the phosphate reabsorptive capacity to accommodate physiologic phosphate requirement. Up to 70% of filtered phosphate is reabsorbed in the proximal tubule where sodium-dependent phosphate transport systems in the brush-border membrane mediate the rate limiting step in the overall phosphate reabsorptive process (Murer et al, 2000;Takeda et al, 2000;Miyamoto et al, 2007;Tenenhouse, 2005;Biber et al, 2009). Three different types of sodiumdependent phosphate transporters have been identified till now, types I, II and III.…”

Section: Phosphate Metabolism In Normal Physiologymentioning

confidence: 99%

“…The sodium-dependent phosphate transport system includes the type IIa and type IIc Nadependent phosphate cotransporters, which are localized in the apical membrane of the renal proximal tubular cells, and the type IIb Na-dependent phosphate cotransporter, which is localized in the apical membrane of the intestinal epithelial cells. The type IIa Nadependent phosphate transporter is the major determinant of plasma phosphate level and urinary phosphate excretion (Murer et al, 2000;Takeda et al, 2000;Miyamoto et al, 2007;Tenenhouse, 2005;Biber et al, 2009 (Xu et al, 2002;Segawa et al, 2004). In addition, fibroblast growth factor 23 (FGF23), a recently identified member of the FGF family, is involved in renal phosphate homeostasis .…”

Section: Phosphate Metabolism In Normal Physiologymentioning

confidence: 99%

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