Molecular mechanisms of long noncoding RNAs on gastric cancer

Li, Tianwen; Mo, Xiaoyan; Fu, Liyun; Xiao, Bingxiu; Guo, Junming

doi:10.18632/oncotarget.6926

Cited by 264 publications

(224 citation statements)

References 95 publications

(96 reference statements)

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“…Long non-coding RNAs (lncRNAs) are a class of regulatory non-coding RNAs (7). Previous studies have investigated the roles of lncRNAs in tumorigenesis and cancer development.…”

Section: Introductionmentioning

confidence: 99%

Plasma lncRNA-GACAT2 is a valuable marker for the screening of gastric cancer

et al. 2016

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Abstract. Long non-coding RNAs (lncRNAs) are crucial in contributing to gastric tumorigenesis and development. However, the diagnostic value of the majority of lncRNAs in gastric cancer (GC) are not clear. The present study investigated the diagnostic value of gastric cancer associated transcript 2 (GACAT2), a lncRNA that is aberrantly expressed in GC tissues. A total of 343 plasma samples from 80 healthy individuals, 29 patients with gastric dysplasia (GD) and 117 paired preoperative and postoperative patients with GC were collected. Plasma GACAT2 levels were subsequently measured by reverse transcription-quantitative polymerase chain reaction. Finally, the associations between plasma GACAT2 levels and various clinicopathological features of patients with GC were assessed. The results demonstrated that plasma GACAT2 levels in preoperative patients with GC were significantly higher than those in the postoperative group (P=0.031). Compared with healthy individuals, plasma GACAT2 levels were significantly increased in patients with GD (P<0.001) and preoperative patients with GC (P=0.040). Moreover, the individual relative changes of plasma GACAT2 expression following surgery were significantly associated with lymphatic metastasis (P=0.034), distal metastasis (P=0.035) and perineural invasion (P=0.039). Therefore, the results of the current study suggest that plasma-based GACAT2 may be developed as a tumor marker to screen and predict the prognosis of GC patients. IntroductionGastric cancer (GC) is one of the most prevalent malignant tumors (1). A number of cancer prevention studies have demonstrated that the most effective way to reduce GC-associated mortality is through early diagnosis and appropriate treatment (2-4). However, the diagnosis rate of early GC remains extremely low (<10%) (5). Patients with GC are usually diagnosed following identification of tumors on B-mode ultrasound, computerized tomography, or magnetic resonance imaging scans. However, early GC tumors are often not large enough to be detected by conventional imaging techniques. Furthermore, the sensitivity and specificity of traditional tumor markers are not satisfactory (6). Thus, investigations into new, more efficient tumor markers are important to improve early diagnosis of this disease.Long non-coding RNAs (lncRNAs) are a class of regulatory non-coding RNAs (7). Previous studies have investigated the roles of lncRNAs in tumorigenesis and cancer development. For example, Zang et al (8) reported that lncRNA-PEG10 expression was upregulated in esophageal cancer tissues, and that it regulated the proliferation and invasion of cancer cells. Furthermore, Shao et al (9) demonstrated that lncRNA-AA174084 expression was downregulated in gastric cancer tissues. A previous study determined that gastric cancer associated transcript 2 (GACAT2) was not only significantly downregulated in gastric cancer tissue, but was also aberrantly expressed in gastric precancerous lesions and gastric cell lines (10).Blood is one of the most commonly used samples in ...

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“…Long non-coding RNAs (lncRNAs) are a class of regulatory non-coding RNAs (7). Previous studies have investigated the roles of lncRNAs in tumorigenesis and cancer development.…”

Section: Introductionmentioning

confidence: 99%

Plasma lncRNA-GACAT2 is a valuable marker for the screening of gastric cancer

et al. 2016

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“…Отмеченное в данном исследовании повы-шение уровня miR-451a в плаценте при нали-чии ПЭ у беременных с ГСД может приводить к подавлению активности PI3K/AKT/mTOR-сигнального пути [11] и VEGF-опосредованного ангиогенеза в ответ на нарушение процессов…”

Section: Discussionunclassified

Peculiarities of placental microRNA expression in pregnancies complicated by gestational diabetes mellitus and preeclampsia

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Vashukova²,

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et al. 2017

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The aim of study was to determine feasible changes of placental miRNAs expression profiles revealed by next generation sequencing (NGS) in pregnancies with GDM complicated or not with PE. Out of 27 miRNAs, studied expression was significantly different (FDR < 0.05) only for his-miR-45a. Comparative analysis of revealed reliable differences in expression of hsa-miR-4532 (p < 0.0001, FDR = 0.0008), hsa-miR-34c-5p (p < 0.0001, FDR = 0.0083), and hsa-miR-193b-5p (p < 0.0001, FDR = 0.0139) in pregnancy complicated by PE, without of GDM. The present results suggest that GDM and PE are associated with specific alterations in the placental miRNA expression profiles. Further studies are needed to verify the role of these microRNA in molecular mechanisms underlying GDM and PE pathogenesis.

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“…MALAT1, for example, can form complexes by complementary base pairing with mRNAs, or, interestingly, with microRNAs (miRNAs), another RNA species that also exert a broad range of regulatory functions in human malignancies. By ''sponging'' miRNA molecules, lncRNAs not only modify the target miRNA levels but also affect the transcriptional profile of the mRNA target of the miRNA [1][2][3]. One such case has been recently reported for GC, where HOTAIR sponges miR-331, alleviating the inhibitory effect of the latter on the oncogene HER2, thus increasing the oncogenic potential of GC cells [3].…”

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confidence: 99%

“…By ''sponging'' miRNA molecules, lncRNAs not only modify the target miRNA levels but also affect the transcriptional profile of the mRNA target of the miRNA [1][2][3]. One such case has been recently reported for GC, where HOTAIR sponges miR-331, alleviating the inhibitory effect of the latter on the oncogene HER2, thus increasing the oncogenic potential of GC cells [3]. All of these interactions give shape to complex competing-endogenous RNA networks.…”

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confidence: 99%

“…The oncogene HOTAIR, one of the most widely studied lncRNAs at the pre-clinical level, has already been identified as a potent prognostic marker for major malignancies of the gastrointestinal tract. implications in GC prognosis include HOTAIR, H19, ANRIL, GHET1, HULC, CCAT2, CCAT1, LSINCT5 (associated with unfavorable prognosis) and GAS5, LET, GACAT1, BM742401, MEG3 (associated with favorable prognosis) [2,3]. The potential of lncRNAs as novel cancer therapeutics has also been on the spotlight recently.…”

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confidence: 99%

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