Molecular mechanisms of leptin and adiponectin in breast cancer

Jardé, Thierry; Perrier, Stéphane; Vasson, Marie‐Paule; Caldefie-Chézet, Florence

doi:10.1016/j.ejca.2010.09.005

Cited by 218 publications

(193 citation statements)

References 68 publications

Supporting

Mentioning

175

Contrasting

Unclassified

Order By: Relevance

“…Leptin is proposed to act initially on breast epithelial cells, transforming them into malignant forms that affect surrounding cells in a paracrine fashion to mediate further cancer cell proliferation [39]. Moreover, addition of leptin to MCF-7 breast cancer cells decreases the expression of the cancer suppression protein p53, exploiting cancer cell survival property [40]. In a female transgenic mouse model susceptible to mammary tumor growth, deficiency of either the leptin gene (ob/ob) [41] or its receptor (db/db) resulted in no development of mammary tumors, whereas tumors were detected in over half of the controls [42].…”

Section: Leptinmentioning

confidence: 99%

Adipose tissue, obesity and adipokines: role in cancer promotion

Booth

Magnuson

Fouts

et al. 2015

Hormone Molecular Biology and Clinical Investigation

216

235

View full text Add to dashboard Cite

Adipose tissue is a complex organ with endocrine, metabolic and immune regulatory roles. Adipose depots have been characterized to release several adipocytokines that work locally in an autocrine and paracrine fashion or peripherally in an endocrine fashion. Adipocyte hypertrophy and excessive adipose tissue accumulation, as occurs during obesity, dysregulates the microenvironment within adipose depots and systemically alters peripheral tissue metabolism. The term "adiposopathy" is used to describe this promotion of pathogenic adipocytes and associated adipose -elated disorders. Numerous epidemiological studies confirm an association between obesity and various cancer forms. Proposed mechanisms that link obesity/adiposity to high cancer risk and mortality include, but are not limited to, obesity-related insulin resistance, hyperinsulinemia, sustained hyperglycemia, glucose intolerance, oxidative stress, inflammation and/or adipocktokine production. Several epidemiological studies have demonstrated a relationship between specific circulating adipocytokines and cancer risk. The aim of this review is to define the function, in normal weight and obesity states, of wellcharacterized and novel adipokines including leptin, adiponectin, apelin, visfatin, resistin, chemerin, omentin, nesfatin and vaspin and summarize the data that relates their dysfunction, whether associated or direct effects, to specific cancer outcomes. Overall research suggests most adipokines promote cancer cell progression via enhancement of cell proliferation and migration, inflammation and anti-apoptosis pathways, which subsequently can prompt cancer metastasis. Further research and longitudinal studies are needed to define the specific independent and additive roles of adipokines in cancer progression and reoccurrence.

show abstract

Section: Leptinmentioning

confidence: 99%

Adipose tissue, obesity and adipokines: role in cancer promotion

Booth

Magnuson

Fouts

et al. 2015

Hormone Molecular Biology and Clinical Investigation

216

235

View full text Add to dashboard Cite

show abstract

“…La asociación fue ligeramente más fuerte para en el colon distal que en el colon proximal (54). Los estudios que han examinado la relación que hay entre el cáncer de recto y el IMC, indican que existe una asociación más reducida que la encontrada para el cáncer de colon (24,27,(35)(36)(37).…”

Section: Cáncer De Colon Y Rectounclassified

Obesidad y cáncer: fisiopatología y evidencia epidemiológica

Fonseca¹,

Farías²

2016

Rev. Médica Risaralda

View full text Add to dashboard Cite

ResumenIntroducción: La obesidad es reconocida como un importante problema de salud pública en todo el mundo, la prevalencia de sobrepeso y obesidad está aumentando a un ritmo alarmante tanto en países desarrollados como en vía de desarrollo, tanto así, que la obesidad ha sido considerada como la epidemia del siglo XXI. El exceso de peso corporal es un factor de riesgo importante en la aparición de enfermedades crónicas y determinados tipos de cáncer, tales como el cáncer de colon, mama en mujeres menopáusicas, endometrio, riñón y cáncer de esófago. Métodos: En junio del 2015, se realizó una búsqueda sistemática de la literatura científica en las principales bases de datos biomédicas: PUBMED, EMBASE, MEDLINE, LILACS, IMBIOMED, COCHRANE, entre el año 1980 y 2015. Utilizando las siguientes palabras clave: cáncer, obesidad, neoplasia, sobrepeso, epidemiologia, asociación y revisión. Resultados: se encontró que existe una asociación estadísticamente significativa entre la obesidad y diversos tipos de cáncer, tales como el cáncer de colon, de mama en mujeres posmenopáusico, de endometrio, de riñón, y de esófago. La obesidad y el sobrepeso pueden tener efectos notables sobre varios sistemas fisiológicos que pueden posteriormente aumentar el riesgo de cáncer. Conclusión: Existe una asociación entre la obesidad y la aparición de diversos tipos de cáncer, la comprensión de los mecanismos causales de esta asociación es importante para la implementación de medidas de salud pública y cambios en el estilo de vida, que busquen prevenir la aparición del cáncer y la obesidad. Palabras clave: cáncer, obesidad, neoplasia, sobrepeso, epidemiologia, asociación y revisión. Obesity and cancer: pathophysiology and epidemiological evidenceBackground: Obesity is said to be a major public health issue around the globe. The prevalence of overweight and obesity is increasing at an alarming rate in developed and developing countries, to the extend that obesity is being regarded as the epidemic of the XXI century. Overweight is an important risk factor in the acquisition of chronic diseases and certain types of cancer such as; colorectal cancer, esophageal cancer, endometrial cancer, kidney cancer, and breast cancer in menopausal women. Methods: In June 2015, a systematic search for scientific literature in the main biomedical databases was performed: PUBMED, EMBASE, MEDLINE, LILACS, IMBIOMED and COCHRANE, making use of the following key words: cancer, obesity, neoplasm, overweight, epidemiology, associations and review, between 1980 and 2015. Results: There is a significant statistical relationship between obesity and several types of cancer, such as; colorectal cancer, esophageal cancer, endometrial cancer, kidney cancer, and breast cancer in post-menopausal women.Obesity and overweight may have considerable effects on several physiological systems that may subsequently increase the risk of cancer. Conclusions: There is a relationship between obesity and the onset of several types of cancer. The understanding of this mechanism is important...

show abstract

“…Dys-regulated expression and function of these adipokines play significant roles in the pathogenesis of obesity-related breast cancer diseases (Deng and Scherer 2010;Paz-Filho et al 2011;Schaffler et al 2007) (Figure 2). A number of them, including leptin and lipocalin-2, promote breast cancer cell survival, proliferation and tumor development, whereas adiponectin, the anti-inflammatory adipokine, has opposite effects (Jarde et al 2011;Leng et al 2011;Wang et al 2007b;. Obese women with reduced serum adiponectin levels and low serum adiponectin levels are associated with an increased risk for breast cancer development and mortality (Duggan et al 2011;Mantzoros et al 2004).…”

Section: Stromal Adipocytes In Obesity-associated Mammary Carcinogenesismentioning

confidence: 99%

“…Leptin is a 16-kDa protein hormone abundantly expressed in white adipose tissue (Jarde et al 2011). The circulating level of leptin is in the range of 5-50 ng/ml .…”

Section: Leptinmentioning

confidence: 99%