Molecular mechanisms of integrin αvβ8 activation regulated by graphene, boron nitride and black phosphorus nanosheets

Boosting Membrane Interactions and Antimicrobial Effects of Photocatalytic Titanium Dioxide Nanoparticles by Peptide Coating

“…[ 79–82 ] Furthermore, preferential nanoparticle interactions with membrane domains [ 83,84 ] are likely important for photocatalytic NPs and deserve further attention, as do the effects of nanoparticles on integrin activation and other key membrane processes by systematically varied nanoparticle properties. [ 85 ] From this perspective, we note that the platform described in the present investigation is compatible with all such future research directions.…”

“…[79][80][81][82] Furthermore, preferential nanoparticle interactions with membrane domains [83,84] are likely important for photocatalytic NPs and deserve further attention, as do the effects of nanoparticles on integrin activation and other key membrane processes by systematically varied nanoparticle properties. [85] From this perspective, 4, the peptide coating does not detrimentally interfere with ROS generation and displays good stability on UV exposure for 1-2 h. As a result of this, binding of peptide-coated TiO 2 is much higher than that of bare TiO 2 NPs, particularly at anionic bacteria-like membranes, and oxidative degradation of the latter on UV exposure strongly boosted by peptide coating, whereas corresponding effects on zwitterionic mammalian-like membranes were much smaller. Mirroring this, LL-37-coated TiO 2 NPs displayed boosted antimicrobial effects against both Gram-negative E. coli and Gram-positive S. aureus bacteria, whereas toxicity against human THP1 monocytes remained low.…”

Nonmonotonic relationship between the degradation of black phosphorus and its bioactivity in suppressing the centrosome polo-like kinase 1

“…For example, studies have shown that BP nanomaterials can elicit immune responses by activating integrins on the cell membrane. 27 Furthermore, BP can directly interact with the cell membrane, extracting significant amounts of phospholipids and reducing cell viability. 28 Additionally, the interactions between BP and other functional biomolecules, such as proteins and DNA, have been explored through experimental and computational methods.…”