Molecular mechanisms of hepatic apoptosis regulated by nuclear factors

Expression pattern and transcriptional regulatory mechanism of noxa gene in grass carp (Ctenopharyngodon idella)

“…This family has been identified pivotal roles in a number of processes, including differentiation, the inflammatory response, liver regeneration, metabolism and numerous other cellular responses [34]. Some studies showed that C/EBPb regulated apoptosis through regulating the expression of some genes [35]. In our study, when the binding sites for FOXO1 and C/EBPb were deleted, the expression level of noxa decreased significantly.…”

Diabetes during pregnancy enhanced neuronal death in the hippocampus of rat offspring

“…Apoptosis, or programmed cell death, is an active, tightly regulated, and genetically encoded form of cell death (Elmore, 2007;Haanen and Vermes, 1996;Brill et al, 1999;Voiculescu et al, 2000;Lichnovsky et al, 1999;Hardy, 1999;Hung and Chow, 1997). This suicidal pathway is characterized by several morphological and biochemical aspects including membrane blebbing, mitochondrial depolarization, condensation of the nucleus and cytoplasm, and degradation of nuclear DNA (Elmore, 2007;Hung and Chow, 1997;Umanskii, 1996;Goldar et al, 2015;Wang, 2015;Wu et al, 2015). Preclinical literature consistently report that the hippocampal environment of hyperglycemic animals favors apoptosis, as evidenced by significant elevations in apoptotic markers (Chen et al, 2012;Foghi and Ahmadpour, 2013;Li et al, 2002a,b;Revsin et al, 2005).…”

Nuclear translocation of nuclear factor kappa B is regulated by G protein signaling pathway in arsenite-induced apoptosis in HBE cell line

“…In response to stimuli (e.g. environmental pollutants and inflammatory cytokines), NF‐κB can rapidly translocate from cytoplasm to nuclear to activate or inhibit the transcription of apoptosis‐related genes (Wang, ). Interestingly, it has been found that arsenite‐induced NF‐κB activation is dose‐ and cell type‐dependent.…”