Molecular Mechanisms of Hemostasis, Thrombosis and Thrombo-Inflammation

Kuijpers, Marijke J. E.; Heemskerk, Johan W. M.; Jurk, Kerstin

doi:10.3390/ijms23105825

Cited by 10 publications

(7 citation statements)

References 21 publications

(24 reference statements)

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“…In contrast, the release of thrombotic elements, including fibrinogen, factor V, and thrombin, can trigger inflammatory cascades, producing an accelerated inflammatory response. Kuijpers et al [31] highlighted the involvement of tissue factor (TF) and other components of the extrinsic coagulation pathway, which play a crucial role in amplifying inflammatory response. Sriram and Insel highlighted, in the context of dysregulation of angiotensin signaling in patients with SARS-CoV-2, the release of pro-inflammatory (e.g., TNFα and RANTES), prothrombotic (e.g., TXA2), platelet-activating factor (PAF) molecules, and a possible increase in MCP-1 levels, which can enhance both inflammation and platelet activation [32].…”

Section: Discussionmentioning

confidence: 99%

Adjuvant Effects of Lavandula angustifolia Oil in Experimental Carrageenan-Induced Thrombosis

But,

Rus,

Ilyés

et al. 2024

Applied Sciences

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Antinociceptive, sedative, anti-inflammatory, and antioxidant effects of lavender oil (LO) have been documented. The aim of our study was to evaluate the adjuvant effects of pretreatment with LO compared to standard treatment (low molecular weight heparin) in thrombosis. We evaluated the effects of two doses of LO in addition to nadroparin calcium (NC) on experimentally induced thrombosis in rats. The groups were as follows: the control (C) group received intraperitoneal (i.p.) saline and vehicle (DMSO), the thrombosis (T) group received saline plus vehicle pretreatment, nadroparin calcium (NC) was administrated subcutaneously (s.c.), TNCL1 and TNCL2 received pretreatment with LO (TNCL1—100 mg/kg body weight (b.w.) i.p. and TNCL2—200 mg/kg b.w. i.p. and NC s.c.). Thrombosis was successfully obtained in all groups, except the C group. Statistically significant differences between groups (p-values < 0.001) were found for the levels of oxidative stress biomarkers (malondialdehyde, nitric oxide, and total oxidative stress) and antioxidant parameters (total antioxidant capacity and thiols), TNF-α, MCP-1, and RANTES. Dose-dependent effects are seen on the biomarkers under evaluation, with higher LO doses producing the best outcomes. When compared to the group receiving standard treatment (NC alone), the LO pretreatment led to an increase in antioxidant levels (p-values < 0.001) and a decrease in oxidative stress and pro-inflammatory levels (p-values < 0.001). Lavender oil associated with NC treatment alleviates the inflammatory components of experimental carrageenan-induced thrombosis in rats by decreasing oxidative stress and inflammatory cytokines and improving antioxidant activity.

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Section: Discussionmentioning

confidence: 99%

Adjuvant Effects of Lavandula angustifolia Oil in Experimental Carrageenan-Induced Thrombosis

But,

Rus,

Ilyés

et al. 2024

Applied Sciences

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“…This eff is particularly pronounced in visceral fat, where ATDPAI-1 expression is largely observ [149,152]. The discovery of the association between the hemostatic and inflammato pathways has revealed a specific function for ATDPAI-1 [103,[153][154][155][156]. In fact, during t In the subsequent subsections, we will examine several adipokines implicated in the pathogenesis of MASLD and their demonstrated involvement in hemostasis mechanisms, as summarized in Table 1.…”

Section: Adipose Tissue-derived Plasminogen Activator Inhibitor-1mentioning

confidence: 99%

“…This effect is particularly pronounced in visceral fat, where ATDPAI-1 expression is largely observed [149,152]. The discovery of the association between the hemostatic and inflammatory pathways has revealed a specific function for ATDPAI-1 [103,[153][154][155][156]. In fact, during the process of inflammation, a significant release of proinflammatory cytokines occurs [153][154][155]157].…”

Section: Adipose Tissue-derived Plasminogen Activator Inhibitor-1mentioning

confidence: 99%

Role of Perturbated Hemostasis in MASLD and Its Correlation with Adipokines

Pezzino,

Luca,

Castorina

et al. 2024

Life

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The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) continues to rise, making it one of the most prevalent chronic liver disorders. MASLD encompasses a range of liver pathologies, from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH) with inflammation, hepatocyte damage, and fibrosis. Interestingly, the liver exhibits close intercommunication with fatty tissue. In fact, adipose tissue could contribute to the etiology and advancement of MASLD, acting as an endocrine organ that releases several hormones and cytokines, with the adipokines assuming a pivotal role. The levels of adipokines in the blood are altered in people with MASLD, and recent research has shed light on the crucial role played by adipokines in regulating energy expenditure, inflammation, and fibrosis in MASLD. However, MASLD disease is a multifaceted condition that affects various aspects of health beyond liver function, including its impact on hemostasis. The alterations in coagulation mechanisms and endothelial and platelet functions may play a role in the increased vulnerability and severity of MASLD. Therefore, more attention is being given to imbalanced adipokines as causative agents in causing disturbances in hemostasis in MASLD. Metabolic inflammation and hepatic injury are fundamental components of MASLD, and the interrelation between these biological components and the hemostasis pathway is delineated by reciprocal influences, as well as the induction of alterations. Adipokines have the potential to serve as the shared elements within this complex interrelationship. The objective of this review is to thoroughly examine the existing scientific knowledge on the impairment of hemostasis in MASLD and its connection with adipokines, with the aim of enhancing our comprehension of the disease.

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“…Coagulation is an important method of physiological hemostasis. In recent years, cardiovascular diseases, including heart disease and stroke related to thrombosis, have become the leading cause of death worldwide [ 88 ]. For patients with cerebral thrombosis, pulmonary thrombosis and stroke, anticoagulants can prevent the formation of blood clots and maintain health [ 11 ].…”

Section: Biological Activity Of Structurally Modified Polysaccharidesmentioning

confidence: 99%

Structural Modification and Biological Activity of Polysaccharides

Zhao

Yang

et al. 2023

Molecules

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Natural polysaccharides are macromolecular substances with a wide range of biological activities. The structural modification of polysaccharides by chemical means can enhance their biological activity. This paper reviews the latest research reports on the chemical modification of natural polysaccharides. At present, the modification methods of polysaccharides mainly include sulfation, phosphorylation, carboxymethylation, socialization, methylation and acetylation. The chemical and physical structures of the modified polysaccharides were detected via ultraviolet spectroscopy, FT-IR, high-performance liquid chromatography, ultraviolet spectroscopy, gas chromatography–mass spectrometry, nuclear magnetic resonance and scanning electron microscopy. Modern pharmacological studies have shown that the modified polysaccharide has various biological activities, such as antioxidant, antitumor, immune regulation, antiviral, antibacterial and anticoagulant functions in vitro. This review provides fresh ideas for the research and application of polysaccharide structure modification.

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Molecular Mechanisms of Hemostasis, Thrombosis and Thrombo-Inflammation

Abstract: In the present decade, we are seeing a rapid increase in available genetics and multiomics information on blood and vascular components of the human and mammalian circulation, involved in haemostasis, athero- and venous thrombosis, and thrombo-inflammation [...]

Cited by 10 publications

References 21 publications

Adjuvant Effects of Lavandula angustifolia Oil in Experimental Carrageenan-Induced Thrombosis

Adjuvant Effects of Lavandula angustifolia Oil in Experimental Carrageenan-Induced Thrombosis

Role of Perturbated Hemostasis in MASLD and Its Correlation with Adipokines

Structural Modification and Biological Activity of Polysaccharides

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