Molecular Mechanisms of Control of Differentiation of Regulatory T-Lymphocytes by Exogenous Melatonin

Glebezdina, N. S.; Олина, А. А.; Nekrasova, I. V.; Куклина, Е. М.

doi:10.1134/s1607672919010058

Cited by 6 publications

(3 citation statements)

References 14 publications

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“…Consistently, exogenous melatonin inhibits Treg cell differentiation, decreases the proportion of CD4 + Foxp3 + cells and the production of TGF‐β via MT1 and MT2 in vitro 66 (Figure 1D). Although melatonin can promote Treg cell formation through RORα, nuclear receptor signaling is significantly weaker than that from membrane receptors 66 …”

Section: Melatonin Modulates Food Allergy Through the Immune System: ...supporting

confidence: 63%

“…Although melatonin can promote Treg cell formation through RORα, nuclear receptor signaling is significantly weaker than that from membrane receptors. 66 Foxp3 + Treg cell-mediated suppression is associated with multiple mechanisms, including producing inhibitory cytokines, such as IL-10, TGF-β and IL-35, and cytolytic molecules such as granzymes A and B, to induce IL-2 deprivation, to inhibit the function of APCs, and to generate adenosine. 58,67 Melatonin treatment increases IL-10 production by increasing the percentages of CD4 + and CD8 + T lymphocytes, 68 which might be mediated by promoting DCs IL-27 secretion through melatonin receptors 69,70 (Figure 1E).…”

Section: Melatonin Regulates Oral Tolerance Via Tregsmentioning

confidence: 99%

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Melatonin in food allergy: Mechanism and potential therapy

Wang

Yan

Hung³

et al. 2023

Journal of Pineal Research

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Food allergy affects more than 500 million people in the world, and its prevalence is increasing at an alarming rate causing serious public health concerns; however, prevention and treatment methods are still under investigation and are relatively scarce so far. Insights on pathophysiology reveal a complex interplay of the immune cells (e.g., DCs, T cells, and B cells) resulting in allergy or tolerance. Studies have shown that melatonin metabolisms are altered in patients with allergic diseases, suggesting that melatonin might impact allergic diseases. Notably, melatonin can orchestrate the differentiation and function of immune cells. Additionally, the disease severities of many allergic diseases and the function of the immune system exhibit circadian rhythmicity. Therefore, melatonin, a rhythm regulator, may also act indirectly on the immune system through the circadian clock to regulate food allergies. Herein, we reviewed the impacts of melatonin on food allergy and its underlying regulatory mechanisms, providing a theoretical reference for melatonin as effective means of prevention and treatment for food allergy in the future.

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Section: Melatonin Modulates Food Allergy Through the Immune System: ...supporting

confidence: 63%

Section: Melatonin Regulates Oral Tolerance Via Tregsmentioning

confidence: 99%

Melatonin in food allergy: Mechanism and potential therapy

Wang

Yan

Hung³

et al. 2023

Journal of Pineal Research

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“…Gut-derived Treg cells have been confirmed to feature in the prognosis of stroke, and studies have confirmed that programmed death protein 1 (PD-1) and CC-chemokine ligand 28 (CCL28) regulate Treg cells ( Wang P. et al, 2019 ; He et al, 2021 ). In addition, melatonin also has a regulatory effect on Treg cells ( Álvarez-Sánchez et al, 2015 ; Glebezdina et al, 2019 ). Therefore, the combined effect of melatonin and gut microbiota whether further affect the prognosis of SCI through Treg cells is worthy of in-depth study.…”

Section: Discussionmentioning

confidence: 99%

Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury

Zhang

Lang²,

Guo³

et al. 2022

Front. Neurosci.

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Spinal cord injury (SCI) is a central nervous system (CNS) disease that can cause sensory and motor impairment below the level of injury. Currently, the treatment scheme for SCI mainly focuses on secondary injury and complications. Recent studies have shown that SCI leads to an imbalance of intestinal microbiota and the imbalance is also associated with complications after SCI, possibly through the microbial-brain-gut axis. Melatonin is secreted in many parts of the body including pineal gland and gut, effectively protecting the spinal cord from secondary damage. The secretion of melatonin is affected by circadian rhythms, known as the dark light cycle, and SCI would also cause dysregulation of melatonin secretion. In addition, melatonin is closely related to the intestinal microbiota, which protects the barrier function of the gut through its antioxidant and anti-inflammatory effects, and increases the abundance of intestinal microbiota by influencing the metabolism of the intestinal microbiota. Furthermore, the intestinal microbiota can influence melatonin formation by regulating tryptophan and serotonin metabolism. This paper summarizes and reviews the knowledge on the relationship among intestinal microbiota, melatonin, and SCI in recent years, to provide new theories and ideas for clinical research related to SCI treatment.

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