Molecular mechanisms of brain peptide-containing drugs: cortexin

Gulyaeva, N. V.

doi:10.17116/jnevro201811810193

Cited by 16 publications

(2 citation statements)

References 13 publications

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“…Neuron-specifi c protein 14-3-3 is a signal transduction factor ("molecular switch"), particularly modulating neuron death. Cytoskeleton proteins (tubulin and actin) also support the normal functioning and integrity of neurons and other brain cells; impairments to their structure are accompanied by cell death [53].…”

Section: Mechanisms Of Nervous System Changes In Covid-19 Penetration...mentioning

confidence: 99%

Postcovid Syndrome – The New Reality

Khoreva

2022

Neurosci Behav Physi

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The second year of the COVID-19 pandemic has demonstrated the need for detection and assessment of the long-term consequences SARS-CoV-2 infection, including adequate cognitive functioning. This review addresses our current understanding of the direct and indirect mechanisms of nervous system infection in COVID-19, paying special attention to cause-effect relationships between SARS-CoV-2 infection and long-term neuropsychological disorders. Understanding the pathogenesis of neurological impairments in COVID-19 is important for studies of the long-term sequelae of the disease and for identifying preventive and therapeutic possibilities in relation to brain damage. Further studies of nervous system lesions in COVID-19 are clearly needed to expand existing knowledge. Early initiation of therapeutic measures for emerging disorders will probably have decisive importance for improving quality of life for many COVID-19 survivors.

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Section: Mechanisms Of Nervous System Changes In Covid-19 Penetration...mentioning

confidence: 99%

Postcovid Syndrome – The New Reality

Khoreva

2022

Neurosci Behav Physi

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“…The advantage of these compounds over other neuroprotectors is the lack of immunogenicity and a wide spectrum of action. It has been shown that ultrashort peptides are involved in the regulation of cell differentiation, apoptosis, and proliferation [10] and also have a neuroprotective effect in in vitro and in vivo AD models [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Neuroepigenetic Mechanisms of Action of Ultrashort Peptides in Alzheimer’s Disease

Ilina

Khavinson

Linkova

et al. 2022

IJMS

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Epigenetic regulation of gene expression is necessary for maintaining higher-order cognitive functions (learning and memory). The current understanding of the role of epigenetics in the mechanism of Alzheimer’s disease (AD) is focused on DNA methylation, chromatin remodeling, histone modifications, and regulation of non-coding RNAs. The pathogenetic links of this disease are the misfolding and aggregation of tau protein and amyloid peptides, mitochondrial dysfunction, oxidative stress, impaired energy metabolism, destruction of the blood–brain barrier, and neuroinflammation, all of which lead to impaired synaptic plasticity and memory loss. Ultrashort peptides are promising neuroprotective compounds with a broad spectrum of activity and without reported side effects. The main aim of this review is to analyze the possible epigenetic mechanisms of the neuroprotective action of ultrashort peptides in AD. The review highlights the role of short peptides in the AD pathophysiology. We formulate the hypothesis that peptide regulation of gene expression can be mediated by the interaction of short peptides with histone proteins, cis- and transregulatory DNA elements and effector molecules (DNA/RNA-binding proteins and non-coding RNA). The development of therapeutic agents based on ultrashort peptides may offer a promising addition to the multifunctional treatment of AD.

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