Molecular Mechanisms of Bortezomib Action: Novel Evidence for the miRNA–mRNA Interaction Involvement

Łuczkowska, Karolina; Rogińska, Dorota; Ulańczyk, Zofia; Paczkowska, Edyta; Schmidt, Christian A.

doi:10.3390/ijms21010350

Cited by 22 publications

(21 citation statements)

References 52 publications

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“…Affymetrix miRNA 4.1 Array Stripes (Affymetrix, Santa Clara, CA, USA) were used for study and performed in n ¼ 3 technical replicates for each miRNA probe. Microarrays were made and analyzed according to the methods described in the previous articles [16,17].…”

Section: Mirna Analysismentioning

confidence: 99%

microRNAs as the biomarkers of chemotherapy-induced peripheral neuropathy in patients with multiple myeloma

Łuczkowska

Rogińska

Ulańczyk

et al. 2021

Leukemia & Lymphoma

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Multiple myeloma (MM) is a malignant, incurable neoplastic disease. The currently used treatment significantly improves the prognosis and extends the survival time of patients. Unfortunately, a common side effect of the therapy is peripheral neuropathy, which may lead to dose reduction or complete treatment discontinuation/modification. In this study, we examined the changes in plasma levels of circulating miRNAs in myeloma patients to define potential factors characteristic for drug-induced peripheral neuropathy (DiPN). Global miRNA expression profile in the plasma of patients with MM during treatment was determined using miRNA microarray technology. Receiver operating characteristic (ROC) analysis allowed the identification of three miRNAs (miR-22-3p; miR-23a-3p; miR-24-3p) that could be a potential biomarker of PN. The most promising results were obtained for miR-22-3p, which was characterized by ROC area under curve (AUC) ¼ 0.807. Our results suggest a relationship between the DiPN in patients with MM and the level of selected miRNAs in the plasma.

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Section: Mirna Analysismentioning

confidence: 99%

microRNAs as the biomarkers of chemotherapy-induced peripheral neuropathy in patients with multiple myeloma

Łuczkowska

Rogińska

Ulańczyk

et al. 2021

Leukemia & Lymphoma

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“…For functional annotation and enrichment analysis, we used DAVID Bioinformatics Resources (Database for Annotation, Visualization, and Integrated Discovery) at http://david.abcc.ncifcrf.gov , as previously described 25 , 26 . Functional annotation charts generated by DAVID with overrepresented gene annotations are shown as bubble plots from BACA BioConductor package ( https://cran.r-project.org/web/packages/BACA/BACA.pdf ).…”

Section: Methodsmentioning

confidence: 99%

Comparative Analysis of Global Gene Expression and Complement Components Levels in Umbilical Cord Blood from Preterm and Term Neonates: Implications for Significant Downregulation of Immune Response Pathways related to Prematurity

Gródecka-Szwajkiewicz

Ulańczyk

Zagrodnik

et al. 2020

Int. J. Med. Sci.

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Background: Preterm birth is the most frequent cause of neonatal death, but its aetiology remains unclear. It has been suggested that the imbalance of immunological mechanisms responsible for maintaining pregnancy is contributing to preterm birth pathogenesis. We aimed to investigate global gene expression and the levels of several complement system components in umbilical cord blood samples from preterm neonates and compare them to term newborns. We sought to examine how differentially expressed genes could affect various immune-related pathways that are believed to be crucial factors in preterm birth. Material and methods: We enrolled 27 preterm infants (<37 weeks GA) and 52 term infants (>37 weeks GA), from which umbilical cord blood samples were collected. From these samples, peripheral blood mononuclear cells were isolated and subsequent RNA isolation was performed. We used Affymetrix Human Gene 2.1 ST Array Strip for microarray experiment and DAVID resources for bioinformatics analysis of the obtained data. Concentrations of C2, C3a, C5/C5a, C9, FactorD, Properdin were measured in umbilical cord blood plasma samples using multiplex fluorescent bead-based immunoassays using Luminex technology. Results: The levels of C3a and C5/5a were significantly elevated in preterm neonates compared to term babies, whereas C9 concentration was evidently increased in term infants. The expression of 250 genes was upregulated at least 2-fold and 3781 genes were downregulated at least 2-fold in preterm neonates in comparison with term infants. Functional annotation analysis revealed that in preterm infants in comparison to term babies there was a significant downregulation of genes encoding several Toll-like receptors, interleukins and genes involved in major signalling pathways (e.g. NF-κB, MAPK, TNF, Notch, JAK) and vital cellular processes (e.g. intracellular signal transduction, protein ubiquitination, protein transport, RNA splicing, DNA-templated transcription). Conclusions: Preterm birth results in immediate and long-term complications. Our results indicate that infants born prematurely show significant differences in complement components concentration and a downregulation of over 3,000 genes, involved mainly in various immune-related pathways, including innate immune response, phagocytosis and TLR function, when compared to full-term babies. Further studies on larger cohorts are needed to elucidate the role of immunity in prematurity.

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“…Bortezomib is an anti-tumor agent that inhibits 26S proteasome degrading proteins. While apoptotic transcription activation in response to bortezomib has also been observed, mechanisms regarding influence on gene silencing mediated regulation by non-coding RNAs remain not fully explained 7 . Bortezomib showed the severe neurotoxicity through apoptosis in PC12 cells.…”

Section: Bortezomibmentioning

confidence: 99%

An Updated Review on Some Neurotoxic Pharmacological Agents Along with their Neurotoxic Mechanisms

Bashir¹,

Aziz²,

Noor³

2021

IJFMT

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This review will provide the vital information about some pharmacological agents which are Neurotoxic. Through this update, Anti-cancer, Anti-bacterial, Analgesic, Psychoactive drug and Anabolic steroid medication are reported briefly regarding their neurotoxic mechanisms. In this review all information regarding neurotoxic drugs is collected from 2020 published work by Web of science, Scopus, PubMed and Google Scholar. It is concluded that all these drugs which the part of our study are neurotoxic. There is need to discover some method to reduce their toxicity and to avoid the chronic use of these medications.

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Molecular Mechanisms of Bortezomib Action: Novel Evidence for the miRNA–mRNA Interaction Involvement

Cited by 22 publications

References 52 publications

microRNAs as the biomarkers of chemotherapy-induced peripheral neuropathy in patients with multiple myeloma

microRNAs as the biomarkers of chemotherapy-induced peripheral neuropathy in patients with multiple myeloma

Comparative Analysis of Global Gene Expression and Complement Components Levels in Umbilical Cord Blood from Preterm and Term Neonates: Implications for Significant Downregulation of Immune Response Pathways related to Prematurity

An Updated Review on Some Neurotoxic Pharmacological Agents Along with their Neurotoxic Mechanisms

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