Molecular mechanisms of antiproliferative effects induced by Schisandra-derived dibenzocyclooctadiene lignans (+)-deoxyschisandrin and (−)-gomisin N in human tumour cell lines

Casarin, Elisabetta; Dall’Acqua, Stefano; Šmejkal, Karel; Šlapetová, Tereza; Innocenti, Gabbriella; Carrara, Maria

doi:10.1016/j.fitote.2014.08.001

Cited by 26 publications

(22 citation statements)

References 29 publications

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“…Both these lignans inhibited cell growth in a dose-dependent manner on both cell lines, but by inducing different types of cell death. In particular, deoxyschisandrin caused apoptosis in colon adenocarcinoma cells (LoVo) but not in ovarian adenocarcinoma cells (2008), while gomisin N induced apoptosis on both the cell lines used (Casarin et al 2014). …”

Section: Current Knowledge Of Bioactivities and Pharmacological Applimentioning

confidence: 99%

Current knowledge of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) as a medicinal plant species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies

Szopa

Ekiert²

2016

Phytochem Rev

262

215

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Schisandra chinensis Turcz. (Baill.) is a plant species whose fruits have been well known in Far Eastern medicine for a long time. However, schisandra seems to be a plant still underestimated in contemporary therapy still in the countries of East Asia. The article presents latest available information on the chemical composition of this plant species. Special attention is given to dibenzo cyclooctadiene lignans. In addition, recent studies of the biological activity of dibenzocyclooctadiene lignans and schisandra fruit extracts are recapitulated. The paper gives a short resume of their beneficial effects in biological systems in vitro, in animals, and in humans, thus underlining their medicinal potential. The cosmetic properties are depicted, too. The analytical methods used for assaying schisandra lignans in the scientific studies and also in industry are also presented. Moreover, special attention is given to the information on the latest biotechnological studies of this plant species. The intention of this review is to contribute to a better understanding of the huge potential of the pharmacological relevance of S. chinensis.

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Section: Current Knowledge Of Bioactivities and Pharmacological Applimentioning

confidence: 99%

Current knowledge of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) as a medicinal plant species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies

Szopa

Ekiert²

2016

Phytochem Rev

262

215

View full text Add to dashboard Cite

show abstract

“…As demonstrated by studies, dibenzocyclooctadiene lignans also have protective effects on the myocardium and properties stimulating the uterine muscle. Moreover, previous studies have confirmed their beneficial effects on the central nervous system by protecting nerve cells from dying and increasing the concentration of neurotransmitters (Hernandez et al 1988;Lu and Liu 1991;Yasukawa et al 1992;Hancke et al 1994;Ko et al 1995;World Health Organization 2007;Hwang et al 2009Hwang et al , 2011Miao et al 2009;Xiao et al 2010c;Chiu et al 2011;Waiwut et al 2012;Chen et al 2012;Casarin et al 2014;Hu et al 2014;Wang et al 2015;Thandavarayan et al 2015;Szopa et al 2016aSzopa et al , 2017a. Detailed directions of the biological activity of dibenzocyclooctadiene lignans are presented in Table 2.…”

Section: Biological Activitiesmentioning

confidence: 88%

Phytochemical studies and biological activity of three Chinese Schisandra species (Schisandra sphenanthera, Schisandra henryi and Schisandra rubriflora): current findings and future applications

Szopa

Barnaś

2018

Phytochem Rev

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Schisandra chinensis (Chinese magnolia vine) is the best-known representative of the genus Schisandra, widely used in the official East-Asian, North American and European medicine. The article recalls the healing value of this species and, above all, presents the current state of knowledge on the chemical composition and biological activity of three other species of the Schisandra genus: Schisandra sphenanthera, Schisandra henryi and Schisandra rubriflora. In addition to dibenzocyclooctadiene lignans (the so-called 'Schisandra chinensis lignans'), they also contain other groups of lignans (e.g. 4aryltetralin, aryltetralone, tetrahydrofuran and butane-type lignans) as the main compounds responsible for biological activity. The lignans are accompanied by other groups of compounds, including triterpenoids and nortriterpenoids. A review of biological studies, e.g. of empirically confirmed hepatoprotective, cytotoxic and anti-HIV-1 activities, proves that these species have a high therapeutic potential and may constitute a new East-Asian proposition for European medicine. The article also draws attention to the possibility of using the biosynthetic potential of the biomass from in vitro cultures of the described species and biotechnological solutions as an alternative to plant raw materials.

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“…GN is known to induce cellular apoptosis in hepatoma cells and leukemia cells (26,27). Additionally, studies on the mechanism of GN-induced anticancer activity against two human tumor cell lines, ovary carcinoma cells and colon adenocarcinoma cells, have been shown (28). GN successfully inhibited growth of these cell lines through induction of different types of cell death.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effects of Schisandra chinensis on the hyperprolactinemia in rat

Hong¹,

Li²,

Jeung³

et al. 2017

International Journal of Oncology

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Prolactin (PRL) is secreted from the pituitary gland in response to eating, mating, and ovulation. Increased serum concentration of PRL during pregnancy contributes to enlargement of the mammary glands of the breasts and prepares for production of milk. However, high PRL levels derived from prolactinoma and hyperprolactinemia induce physiological disorders such as infertility and early menopause. Natural compounds isolated from S. chinensis have been known to possess anti-oxidative, anti-inflammatory and anti-diabetic effects. In the present study, we examined the therapeutic effect of S. chinensis and its single compounds on hyperprolactinemia in the pituitary gland. In rat pituitary cells, PRL expression levels were examined using real-time PCR and western blot assay. Crude S. chinensis extract and its single compound, gomisin N, reduced mRNA and protein levels of PRL in GH3 cells. In addition, cell proliferation and PRL target gene expression in cells were modulated by S. chinensis. Similar to the in vitro experiments, crude S. chinensis extract and gomisin N reduced PRL levels in the pituitary and serum of immature female rats. These results show that S. chinensis and its single compound, gomisin N, are regulators of PRL production and may be candidates for treatment of hyperprolactinemia and prolactinoma.

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Molecular mechanisms of antiproliferative effects induced by Schisandra-derived dibenzocyclooctadiene lignans (+)-deoxyschisandrin and (−)-gomisin N in human tumour cell lines

Cited by 26 publications

References 29 publications

Current knowledge of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) as a medicinal plant species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies

Current knowledge of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) as a medicinal plant species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies

Phytochemical studies and biological activity of three Chinese Schisandra species (Schisandra sphenanthera, Schisandra henryi and Schisandra rubriflora): current findings and future applications

Therapeutic effects of Schisandra chinensis on the hyperprolactinemia in rat

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