Molecular Mechanisms Leading from Periodontal Disease to Cancer

Sobocki, Bartosz Kamil; Basset, Charbel A.; Bruhn-Olszewska, Bożena; Olszewski, Paweł; Szot, Olga; Kaźmierczak-Siedlecka, Karolina; Guziak, Mateusz; Nibali, Luigi; Leone, Angelo

doi:10.3390/ijms23020970

Cited by 20 publications

(19 citation statements)

References 167 publications

(227 reference statements)

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“…It was also proven that the in vitro exposure of oral epithelial cells to LPS might result in histone modifications, the activation of coactivators (e.g., p300/CBP), and an NF-κB increase. Moreover, Toll-like receptors 1,2, and 4 activated by pathogens also induce histone acetylation [ 76 ]. Knowing that PD can enhance systemic immune response and may change the cytokine profile in blood [ 77 ], HM seems to be one of the factors inducing this process.…”

Section: Epigenetic Regulations In the Pathophysiology Of Periodontal...mentioning

confidence: 99%

Association between Maternal Periodontitis and Development of Systematic Diseases in Offspring

Starzyńska

Wychowański

Nowak

et al. 2022

IJMS

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Periodontal disease (PD) is one of the most common oral conditions affecting both youths and adults. There are some research works suggesting a high incidence of PD in pregnant women. As an inflammatory disease of bacterial origin, PD may result in the activation of the pathways affecting the course and the pregnancy outcome. The authors, based on the literature review, try to answer the PICO question: Does maternal periodontitis (exposure) influence the incidence of complications rates in pregnancy and the development of systemic diseases in childhood and adult offspring (outcome) in the humans of any race (population) compared to the offspring of mothers with healthy periodontium (comparison)? The authors try to describe the molecular pathways and mechanisms of these interdependencies. There is some evidence that maternal periodontitis may affect the pregnancy course and outcome, resulting in preeclampsia, preterm delivery, vulvovaginitis and low birth weight. It can be suggested that maternal periodontitis may affect offspring epigenome and result in some health consequences in their adult life.

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Section: Epigenetic Regulations In the Pathophysiology Of Periodontal...mentioning

confidence: 99%

Association between Maternal Periodontitis and Development of Systematic Diseases in Offspring

Starzyńska

Wychowański

Nowak

et al. 2022

IJMS

Self Cite

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“…Comparison of PBMC subtypes in PRF of periodontitis patients with and without underlying neoplastic process demonstrates that CD3+, CD3+ CD4+ CD8+, CD3+ CD4+ CD8− and CD14+ proportions did not differ between PRF samples of patient’s subgroups. A previous study described the association between periodontitis and the bioactive cancer process, which can be the key to similarities in cell distribution in whole blood and PRF 27 . The chronic inflammatory process of periodontal disease with constant immunological stimulation and oxidative stress leads to the systematic effect and neoplastic process development 27 .…”

Section: Discussionmentioning

confidence: 99%

“…A previous study described the association between periodontitis and the bioactive cancer process, which can be the key to similarities in cell distribution in whole blood and PRF 27 . The chronic inflammatory process of periodontal disease with constant immunological stimulation and oxidative stress leads to the systematic effect and neoplastic process development 27 . In human studies, a significantly higher proportion of intermediate monocytes and macrophages was detected in inflamed gingival tissue compared to healthy tissues and periodontal disease affected tissues 28 .…”

Section: Discussionmentioning

confidence: 99%

Peripheral mononuclear cells composition in platelet-rich fibrin in canines with chronic conditions

Jasineviciute

Grigas

Ziukaite

et al. 2022

Sci Rep

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Platelet-rich fibrin (PRF) is a hot research topic because of its regenerative effect in humans. However, data reporting about its application in companion animals is lacking. The study aimed to supplement currently available data on PRF cell composition in canine patients by isolating peripheral blood mononuclear cells (PBMC), namely T cells, matured B cells, monocytes and macrophages, and adapting current protocols of cell flow cytometry for PRF analysis. The canine patient population was divided into three subgroups: animals with periodontitis only, animals with neoplasia and periodontitis, and healthy controls. Individual clinical parameters of the patients and evaluation of the wound healing quality were included in the research. In the present study, canine PRF cell composition was analyzed for the first-time using cell flow cytometry protocol. A higher proportion of PBMC cells related to wound healing (CD3+, CD3+ CD4+ CD8−, CD14+) were found in the PRF of control, periodontitis and neoplasia groups compared to the respective blood samples, which implies a positive outcome associated with clinical PRF usage in canine patients. Proportions of monocytes and macrophages were higher in PRF samples compared to the blood of healthy patients and periodontitis-affected patients. However, inflammatory and neoplastic processes do not affect the distribution of PBMC.

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“…The most widely reported associations in the literature on the subject are links between periodontitis and diabetes [ 20 ], cardiovascular disease [ 24 ], pregnancy and perinatal complications [ 25 ], obesity and metabolic syndrome [ 26 ], as well as rheumatoid arthritis [ 27 ], cancer [ 28 ], respiratory diseases [ 29 ], Alzheimer’s disease [ 30 ] and other cognitive disorders [ 16 ]. This knowledge is available to professionals but is not always available to a wider audience, including patients.…”

Section: Introductionmentioning

confidence: 99%

Periodontitis-Related Knowledge and Its Relationship with Oral Health Behavior among Adult Patients Seeking Professional Periodontal Care

Dolińska

Milewski

Gumińska

et al. 2022

JCM

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Background: Periodontitis is a chronic inflammatory disease that not only damages the stomatognathic system, but may also adversely influence other systems and organs. Patients with low oral health literacy levels are more prone to gingivitis/periodontitis and have a more severe disease course. Methods: A written questionnaire was carried out to assess the knowledge of patients of the Outpatient Clinic of Department of Periodontal and Oral Mucosa Diseases, Medical University of Bialystok, Poland. The questions concerned knowledge regarding the causes of periodontal disease, its risk factors, and the connection between periodontal disease and general health status. To analyze the population, patients were divided according to gender, age and if they were first-time or regular outpatients. Results: Written questionnaires were completed by a total of 302 patients. In the studied population, we noted knowledge deficits, particularly related to weaker periodontal disease risk factors (stress, diabetes, osteoporosis, obesity) and the genetic factor, which is the determinant of periodontitis. The patients’ awareness of the role of plaque bacteria and the effect of smoking on the periodontium was at a relatively high level. The respondents were also aware of the impact of periodontal disease on general health as well as the role of oral hygiene in preventing the disease. At the same time, few of them (26%) used interdental brushes or an irrigator (8%). Conclusions: We demonstrated that patients have an insufficient level of knowledge related to risk factors as well as the prevention of periodontal disease. Awareness of the extent of oral health literacy among patients will help to identify key issues connected with health education interventions

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Molecular Mechanisms Leading from Periodontal Disease to Cancer

Cited by 20 publications

References 167 publications

Association between Maternal Periodontitis and Development of Systematic Diseases in Offspring

Association between Maternal Periodontitis and Development of Systematic Diseases in Offspring

Peripheral mononuclear cells composition in platelet-rich fibrin in canines with chronic conditions

Periodontitis-Related Knowledge and Its Relationship with Oral Health Behavior among Adult Patients Seeking Professional Periodontal Care

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